Elena Tonti, Nereida Jiménez de Oya, Gabriele Galliverti, E. Ashley Moseman, Pietro Di Lucia, Angelo Amabile, Stefano Sammicheli, Marco De Giovanni, Laura Sironi, Nicolas Chevrier, Giovanni Sitia, Luigi Gennari, Luca G. Guidotti, Ulrich H. von Andrian et al.
Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4+ and γδ T cells, neutrophils or dendritic cells and their effect does not rely on local macrophage depletion nor does …
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