Bisphenol analogues in surface water and sediment from the shallow Chinese freshwater lakes: Occurrence, distribution, source apportionment, and ecological and human health risk

Yan, Zhengyu; Liu, Yanhua; Yan, Kun; Wu, Shiquan; Han, Zhihua; Guo, Ruixin; Chen, Meihong; Yang, Qiulian; Zhang, Shenghu; Chen, Jianqiu

doi:10.1016/j.chemosphere.2017.06.010

Cited by 161 publications

(52 citation statements)

References 56 publications

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“…For this purpose, we selected BPS concentrations ranging from 0.5 to 500 μg/L, where the lowest doses are of the same order of magnitude as those detected in natural environments, wastewater, and the urine of exposed populations. Some mean maximum concentrations reported in aquatic environments are 0.16 and 1.6 μg/L for Taihu Lake (China) [ 39 , 40 ], and 7.2 μg/L for Adyar River (India) [ 41 ]. Sun et al .…”

Section: Discussionmentioning

confidence: 99%

The BPA-substitute bisphenol S alters the transcription of genes related to endocrine, stress response and biotransformation pathways in the aquatic midge Chironomus riparius (Diptera, Chironomidae)

et al. 2018

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Bisphenol S (BPS) is an industrial alternative to the endocrine disruptor bisphenol A (BPA), and can be found in many products labeled “BPA-free”. Its use has grown in recent years, and presently it is considered a ubiquitous emerging pollutant. To date there is a lack of information on the effects of BPS on invertebrates, although they represent more than 95% of known species in the animal kingdom and are crucial for the structure and proper function of ecosystems. In this study, real-time RT-PCR was used to determine the early detrimental effects of BPS on the transcriptional rate of genes in the model species Chironomus riparius, specifically those related to the ecdysone pathway (EcR, ERR, E74, Vtg, cyp18a1) crucial for insect development and metamorphosis, stress and biotransformation mechanisms (hsp70, hsp40, cyp4g, GPx, GSTd3) that regulate adaptive responses and determine survival, and ribosome biogenesis (its2, rpL4, rpL13) which is essential for protein synthesis and homeostasis. While 24-hour exposure to 0.5, 5, 50, and 500 μg/L BPS had no effect on larval survival, almost all the studied genes were upregulated following a non-monotonic dose-response curve. Genes with the greatest increases in transcriptional activity (fold change relative to control) were EcR (3.8), ERR (2), E74 (2.4), cyp18a1 (2.5), hsp70 (1.7), hsp40 (2.5), cyp4g (6.4), GPx (1.8), and GST (2.1), while others including Vtg, GAPDH, and selected ribosomal genes remained stable. We also measured the transcriptional activity of these genes 24 hours after BPS withdrawal and a general downregulation compared to controls was observed, though not significant in most cases. Our findings showed that BPS exposure altered the transcriptional profile of these genes, which may have consequences for the hormone system and several metabolic pathways. Although further research is needed to elucidate its mode of action, these results raise new concerns about the safety of BPA alternatives.

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Section: Discussionmentioning

confidence: 99%

The BPA-substitute bisphenol S alters the transcription of genes related to endocrine, stress response and biotransformation pathways in the aquatic midge Chironomus riparius (Diptera, Chironomidae)

et al. 2018

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“…Recent studies have shown that BPS, BPF and other BPA analogues were widely detected in the water environment, and the pollution levels have an increasing trend [11,12]. And the current researches have indicated that BPS, BPAF and BPF can be adsorbed by aquatic organisms, and pose a serious threat to the whole 2 ecosystem as BPA [13,14]. Research is still needed to better elucidate the environmental sources, distribution and fate of bisphenol analogues (BPs).…”

Section: Introductionmentioning

confidence: 99%

Occurrence, Distribution and Ecological Risk of Bisphenol Analogues in The Surface Water from A Water Diversion Project in Nanjing, China

Zheng¹,

Liu²,

Ren³

et al. 2019

Preprint

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Because of the widespread use of bisphenol analogues (BPs) as the alternatives to bisphenol A (BPA), they have attracted considerable attention for health risk in aquatic ecosystems. The occurrence and distribution of six BPs were researched in soluble phase (< 5 kDa), colloidal phase (5 kDa to 1 µm) and suspended particulate matter (SPM > 1 µm) in a water diversion project of Nanjing, China. Except for bisphenol Z, all BPs were detected in the two or three phases, the total concentrations of detected BPs were 161-613 ng/L, 5.19-77.2 ng/L and 47.5-353 ng/g for the soluble phase, colloidal phase and SPM, respectively. Among the detected compounds, BPA still the dominant BPs in the soluble and colloidal phases, followed by BPS, while BPAF was the major contaminant in SPM, followed by BPA. The mean contribution proportions of colloids were 1-2 orders of magnitude higher than SPM, suggesting that colloids have an obvious impact on regulating BPs’ environmental behaviors. In terms of spatial distribution, although the water diversion project could reduce the pollution levels of BPs, which might further affect the ecological security of the Yangtze River.

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“…Considering the organic pollutants observed in this study, only for BPA, BPB, BPF and BPS were reported concentration values in the aquatic environment. Compared with the concentration level detected in rivers and lakes from countries with large populations, such as China, Japan or India, the values determined in the surface waters taken from the Danube Delta were much lower [12,[18][19][20]. Comparing the data obtained with those reported https://doi.org/10.37358/RC.20.7.8250 in Germany, it can be observed an extremely closed concentration range for BPA values [21].…”

Section: Comparison With Similar Studiesmentioning

confidence: 53%

Occurrence of Phenolic Endocrine Disruptors in Danube Delta, Romania

Chiriac¹,

Păun²,

Iancu³

et al. 2020

Rev. Chim.

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In the last decade, the use of chemical compounds with a molecular structure similar to that of BPA has been reported more and more as alternatives to BPA in various industrial products. This comes as a result of banning partial or total use of BPA because of its endocrine disrupting properties. However, bisphenol analogues have been shown to have similar or even greater negative properties than BPA. Thus, particular attention has been given to the risks they have for aquatic systems and human health. In this context, the present study aimed to determine the concentration level at which some of the bisphenol analogues (BPS, BPB, BPE, BPC and BPE), BPA and its major metabolite, 4-HAP, are found in surface waters. For this purpose, 11 sampling points were established in the geographical area of the Danube Delta. Among the seven targeted pollutants, only four were detected in the analyzed samples. 4-HAP metabolite was the most abundant compound in the analyzed samples, with concentrations ranging from 3.56 to 30.9 ng/L. BPA concentrations were, in most cases approximately three times lower than those determined for 4-HAP. The next bisphenol analog after 4-HAP, in the decreasing order of concentrations, was BPE, for which the concentration level ranged between LOQ and 12.4 ng/L. Lowest concentrations were detected for BPS, with a maximum level of 1.96 ng/L.

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Bisphenol analogues in surface water and sediment from the shallow Chinese freshwater lakes: Occurrence, distribution, source apportionment, and ecological and human health risk

Cited by 161 publications

References 56 publications

The BPA-substitute bisphenol S alters the transcription of genes related to endocrine, stress response and biotransformation pathways in the aquatic midge Chironomus riparius (Diptera, Chironomidae)

The BPA-substitute bisphenol S alters the transcription of genes related to endocrine, stress response and biotransformation pathways in the aquatic midge Chironomus riparius (Diptera, Chironomidae)

Occurrence, Distribution and Ecological Risk of Bisphenol Analogues in The Surface Water from A Water Diversion Project in Nanjing, China

Occurrence of Phenolic Endocrine Disruptors in Danube Delta, Romania

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