Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern
Adonis A. Rubio,
Viren A. Baharani,
Bernadeta Dadonaite
et al.
Abstract:The ongoing emergence of SARS-CoV-2 variants of concern (VOCs) that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized N-terminal domain (NTD) and receptor binding domain (RBD)-specific monoclonal antibodies previously isolated from COVID-19 convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, the NTD-specific antibody C1596 displayed the greatest breadth… Show more
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