Biochemical Pharmacology volume 80, issue 2, P247-254 2010 DOI: 10.1016/j.bcp.2010.03.021 View full text
Wei Chen, Jie Hou, Yan Yin, Jongchol Jang, Zhongliang Zheng, Handong Fan, Guolin Zou

Abstract: In this study, the apoptotic effect of alpha-bisabolol, a sesquiterpene, against human liver carcinoma cell line HepG2 was investigated. MTT assay showed alpha-bisabolol could effectively induce cytotoxicity in several human cancer cell lines (PC-3, Hela, ECA-109 and HepG2). The results of nuclei morphology examination, DNA fragmentation detection, flow cytometry analysis and cleavage of poly(ADP-ribose) polymerase and caspases indicated alpha-bisabolol might induce dose- and time-dependent apoptosis in HepG2 …

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