Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults.

Dabelea, Dana; Pettitt, David J.; Hanson, Robert L.; Imperatore, Giuseppina; Bennett, P. H.; Knowler, William C.

doi:10.2337/diacare.22.6.944

Cited by 239 publications

(151 citation statements)

References 10 publications

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“…Our finding of a possible U-shaped association between birthweight and type 2 diabetes is in agreement with some studies [19,20], but most report an inverse relationship (reviewed in [3]). In agreement with Whincup et al (1997) [21], we found that the post-natal growth effect was stronger than the pre-natal effect indicated by birthweight.…”

Section: Discussionsupporting

confidence: 93%

Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

et al. 2005

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Aims/hypothesis: We assessed whether low birthweight or early adiposity rebound was more strongly associated with type 2 diabetes, and whether any effect of low birthweight or early adiposity rebound was explained by adult BMI, adult height, social class of subject or of his/her father, or maternal or paternal diabetes. Methods: Cox's proportional hazard models were used on data from the National Birth Cohort Study (the MRC National Survey of Health and Development), which was begun in 1946 and had self-reported physician-diagnosed diabetes with age at onset ranging from 31 to 53 years (n=78 cases, and n=47 cases in the multivariate analysis) as the outcome. Results: A U-shaped association between birthweight and type 2 diabetes rates was close to statistical significance (quadratic term p value=0.08). Younger age at adiposity rebound was associated with increased rates of type 2 diabetes (test for trend p=0.002), the association being robust to adjustment for each of sex, birthweight, weight at 2 years, father's social class, parental diabetes, and own social class. The effect of early adiposity rebound was very slightly reduced by adjustment for sex and adult height (p=0.003), but considerably reduced after adjustment for sex and adult BMI (test for trend p=0.1), and further reduced (p=0.4) after additional adjustment for birthweight, weight at 2 years, adult height, social class of subject and of his/her father, and parental diabetes. Conclusions/interpretation: Early adiposity rebound was associated with an increased rate of type 2 diabetes independently of birthweight, but its effect was mostly through high adult BMI. Parental diabetes and possibly low weight at 2 years were also risks.

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Section: Discussionsupporting

confidence: 93%

Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

et al. 2005

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“…Our study confirms that BMI is a powerful determinant of HOMA%S and HOMA%b, as others have shown [4,7,10]. Our study demonstrates that the association of BMI z-score with low HOMA%S and high HOMA%b may correspond to an increase of HOMA%b which compensates for the low HOMA% S. Previous studies have reported that the effect of BMI on insulin resistance is more consistent and of higher effect size than BW [10,14], as also shown in our study. Results from a study using an animal model have shown that decreased fetal size is associated with beta-cell hyperfunction in early life, which is consistent with our findings [13].…”

Section: Interpretation Of the Findingssupporting

confidence: 91%

“…In our study BW z-score was associated with HOMA%b before and after adjustment for current BMI z-score, but only in Ribeirao Preto. There was no suggestion of a non-linear association between BW and either insulin resistance or secretion in our study, as has been previously suggested [14,29].…”

Section: Interpretation Of the Findingssupporting

confidence: 50%

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Birth weight, current body mass index, and insulin sensitivity and secretion in young adults in two Latin American populations

Silva

Santos

Amigo

et al. 2012

Nutrition, Metabolism and Cardiovascular Diseases

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“…Clinical studies have demonstrated that maternal diabetes increases the offspring's risk of developing type 2 diabetes [11,23,24]. Basic research in animal models of diabetes has shown similar effects [7,25,26].…”

Section: Discussionmentioning

confidence: 99%

Long-term effect of maternal obesity on pancreatic beta cells of offspring: reduced beta cell adaptation to high glucose and high-fat diet challenges in adult female mouse offspring

Han

Epstein

et al. 2005

Diabetologia

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Aim/hypothesis: Obesity is a global problem with high risks of cardiovascular diseases, stroke and type 2 diabetes. It is well known that maternal obesity affects offspring by inducing malformation, functional abnormalities in many organs and cells, and by increased risk of obesity and type 2 diabetes. However, little is known about abnormalities induced by maternal obesity in pancreatic beta cells of offspring. Methods: We used mouse mothers with the Agouti yellow modification on a C57BL/6 background as a maternal model of normoglycaemic obesity, and produced Agouti-negative offspring. Half of the offspring were fed a high-fat diet. Offspring glucose tolerance was tested at different ages, and animals were killed at 50 weeks of age for islet function analysis. Results: Maternal obesity impaired glucose tolerance in female offspring fed a high-fat diet, and significantly reduced insulin secretion at 50 weeks of age in female offspring that had been fed a normal diet and high-fat diet. Insulin secretion and glucose potentiation from these islets were significantly reduced. Islet protein, DNA and insulin contents were increased while glyceraldehyde-3-phosphate dehydrogenase and transketolase activities were reduced in female offspring. Conclusions/interpretation: Our results indicate that maternal obesity has a long-term effect on the beta cells of female, but not of male, offspring, and leads to increased risk of gestational diabetes and type 2 diabetes in the offspring's later lives.

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Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults.

Cited by 239 publications

References 10 publications

Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

Early growth and type 2 diabetes: evidence from the 1946 British birth cohort

Birth weight, current body mass index, and insulin sensitivity and secretion in young adults in two Latin American populations

Long-term effect of maternal obesity on pancreatic beta cells of offspring: reduced beta cell adaptation to high glucose and high-fat diet challenges in adult female mouse offspring

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