Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence

Hulst, Andraea Van; Barnett, Tracie A.; Paradis, Gilles; Roy-Gagnon, Marie-Hélène; Gómez-López, L.; Henderson, Mélanie

doi:10.1161/jaha.117.006302

Cited by 23 publications

(18 citation statements)

References 57 publications

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“…In agreement with some 9,28,31 but not all 72 prior investigations, we found a statistically significant association between birth weight and childhood HDL (positive), and TG (negative). Inclusion of the child's current BMI strengthened these associations.…”

Section: Lipidssupporting

confidence: 93%

Association between birth weight and childhood cardiovascular disease risk factors in West Virginia

Umer

Hamilton

Cottrell

et al. 2019

J Dev Orig Health Dis

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The reported associations between birth weight and childhood cardiovascular disease (CVD) risk factors have been inconsistent. In this study, we investigated the relationship between birth weight and CVD risk factors at 11 years of age. This study used longitudinally linked data from three cross-sectional datasets (N = 22,136) in West Virginia; analysis was restricted to children born full-term (N = 19,583). The outcome variables included resting blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)] and lipid profile [total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, non-HDL, and triglycerides (TG)]. Multiple regression analyses were performed, adjusting for child’s body mass index (BMI), sociodemographics, and lifestyle characteristics. Unadjusted analyses showed a statistically significant association between birth weight and SBP, DBP, HDL, and TG. When adjusted for the child’s BMI, the association between birth weight and HDL [b = 0.14 (95% CI: 0.11, 0.18) mg/dl per 1000 g increase] and between birth weight and TG [b = –0.007 (–0.008, –0.005) mg/dl per 1000 g increase] remained statistically significant. In the fully adjusted model, low birth weight was associated with higher LDL, non-HDL, and TGs, and lower HDL levels. The child’s current BMI at 11 years of age partially (for HDL, non-HDL, and TG) and fully mediated (for SBP and DBP) the relationship between birth weight and select CVD risk factors. While effects were modest, these risk factors may persist and amplify with age, leading to potentially unfavorable consequences in later adulthood.

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Section: Lipidssupporting

confidence: 93%

Association between birth weight and childhood cardiovascular disease risk factors in West Virginia

Umer

Hamilton

Cottrell

et al. 2019

J Dev Orig Health Dis

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“…An increase in [33]. Other studies have found rapid weight gain early in childhood to be associated with cardiometabolic risk factors in later childhood [34,35]. These findings suggest that a child presenting with an increase in zBMI over time may need to be monitored for the development of cardiometabolic risk factors, even when the BMI values remain below the age and sex-adjusted cutoff for overweight.…”

Section: Discussionmentioning

confidence: 83%

Determinants of new onset cardiometabolic risk among normal weight children

et al. 2019

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Objective To identify determinants for the development of "normal weight metabolically unhealthy" (NWMU) profiles among previously metabolically healthy normal weight children. Methods The QUALITY cohort comprises youth 8-10 years of age with a parental history of obesity (n = 630). Of these, normal weight children with no metabolic risk factors were identified and followed up 2 years later (n = 193). Children were classified as NWMU if they remained normal weight but developed at least one cardiometabolic risk factor. They were classified as normal weight metabolically healthy otherwise. Multivariable logistic regression models were used to identify whether adiposity (anthropometrics and DXA), lifestyle habits (physical activity, screen time, vegetables, and fruit-and sugar-sweetened beverages intake), fitness, and family history of cardiometabolic disease were associated with new onset NWMU. Results Of the 193 normal weight and metabolically healthy children at baseline, 45 (23%) became NWMU 2 years later (i.e., 48% had elevated HDL cholesterol, 13% had elevated triglycerides, and 4% had impaired fasting glucose). Changes in adiposity between baseline and follow-up were associated with an increased risk of NWMU for all adiposity measures examined (e.g., for ΔzBMI OR = 3.95; 95% CI: 1.76, 8.83). Similarly, a 2-year change in screen time was associated with incident NWMU status (OR = 1.24; 95% CI 1.04, 1.49). Conclusions Children who increase their adiposity levels as they enter puberty, despite remaining normal weight, are at risk of developing cardiometabolic risk factors. Studies examining long-term consequences of NWMU profiles in pediatrics are needed to determine whether changes in screening practice are warranted.

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“…However, some studies have showed little effect of LBW on blood pressure in young adults [9,10]. On the other hand, some recent studies suggest that the co-existence of low birthweight and later obesity, rather than low birthweight itself, was a strong risk factor of HBP during adolescence [11,12,13,14,15,16,17]. The relationship between LWB and HBP remains unclear, and obesity during school-age is seldom brought into consideration.…”

Section: Introductionmentioning

confidence: 99%

Low Birthweight Is Associated with Higher Risk of High Blood Pressure in Chinese Girls: Results from a National Cross-Sectional Study in China

Wang

Dong

Zou

et al. 2019

IJERPH

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Objective: To investigate the relationship between low birthweight (LBW) and blood pressure and to assess whether LBW leads to a higher risk of high blood pressure (HBP) by gender in Chinese students aged 6–18 years. Also, to investigate whether the association was affected by childhood obesity. Methods: Data was obtained from a baseline dataset of a national school-based program. Anthropometric parameters, including height, weight, and blood pressure, were measured, while birthweight and other characteristics were obtained from questionnaires. Stratified chi-squared tests were used to compare the prevalence of HBP between LBW and normal birthweight (NBW) groups in each age and sex category. Multivariable logistic regressions were conducted to estimate the HBP risks in each birthweight group. Results: Both systolic and diastolic blood pressure showed a U-shaped relationship with increased birthweight. Compared to NBW groups, LBW girls showed a higher HBP risk, with an odds ratio of 1.29 (95% confidence interval (CI): 1.02, 1.64, p = 0.033), regardless of their current body mass index status, while no significant association in boys was found. Conclusions: Low birthweight is associated with higher HBP risk in adolescent girls, regardless of their childhood BMI status.

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Birth Weight, Postnatal Weight Gain, and Childhood Adiposity in Relation to Lipid Profile and Blood Pressure During Early Adolescence

Cited by 23 publications

References 57 publications

Association between birth weight and childhood cardiovascular disease risk factors in West Virginia

Association between birth weight and childhood cardiovascular disease risk factors in West Virginia

Determinants of new onset cardiometabolic risk among normal weight children

Low Birthweight Is Associated with Higher Risk of High Blood Pressure in Chinese Girls: Results from a National Cross-Sectional Study in China

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