OBJECTIVE:To determine if maternal hypoglycemia is associated with adverse perinatal outcome, particularly low birth weight.
STUDY DESIGN:In this prospective study, all patients after 24 weeks' gestation were screened for gestational diabetes using 50 gm of glucola (oral) followed by a 1-hour plasma glucose measurement and hypoglycemia was defined as Յ88 mg/dl.
RESULTS:In these 426 women the mean (Ϯ SD) 1-hour plasma glucose value was 99.8 Ϯ 22.7 mg/dl. Of these, 16 were diagnosed with gestational diabetes and 46 were lost to follow-up leaving 364 patients; 116 with hypoglycemia and 248 with euglycemia. Women with hypoglycemia weighed less at the beginning of pregnancy and at delivery, but total weight gain during pregnancy was similar between both groups. There was no difference between groups in maternal symptomatology, birth weight, or the rate of fetal growth restriction.
CONCLUSION:Hypoglycemia on the 1-hour glucola screen is not predictive of fetal growth restriction or other adverse perinatal consequence.It is common in the United States to screen all pregnant females between 24 to 28 weeks for gestational diabetes with the 50-gm glucola followed by a 1-hour plasma glucose measurement. 1 An elevated glucose screen (Ն140 mg/dl%) can be associated with gestational diabetes, which occurs in 2% to 3% of all pregnancies. 2 The diagnosis of gestational diabetes, confirmed by 3-hour glucose tolerance testing, has been shown to be associated with adverse perinatal outcome. 3 Similarly, hypoglycemia has been found to be associated with increased perinatal morbidity. 2,3 The finding of adverse fetal effects has not been substantiated by more recent reports, and the relationship of a low glucose to maternal weight and other maternal factors have not been well explained.The goal of this study was to ascertain whether hypoglycemia noted on routine screening for gestational diabetes will select a patient population who is at risk for poor perinatal outcome.
Materials and MethodsIn this prospective study, all patients with singleton pregnancies obtaining obstetric care at the University of Mississippi Medical Center were given 50 gm of glucola orally followed by a 1-hour plasma glucose measurement at Ն24 weeks' gestation. To standardize results, participants were instructed to avoid smoking, chewing gum, eating candy, or using cough drops prior to the test. To minimize false low results, patients were observed by clinic staff for compliance with complete ingestion of the 50-gm glucola solution within 5 minutes. If any value was Ն140 mg/dl, a 3-hour, 100-gm oral glucose tolerance test was performed. Gestational diabetes was diagnosed by the standard American College of Obstetricians and Gynecologists criteria. 4 To control for the potential confounding effect of hyperglycemia on perinatal outcome, patients with the diagnosis of diabetes were excluded from analysis. Hypoglycemia was defined as a plasma glucose value of Յ88 mg/dl, as described by Abell et al. 3 Patients were followed prospectively and managed as obstetric...