Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response

Bouler, Jean‐Michel; Pilet, Paul; Gauthier, Olivier; Verron, Elise

doi:10.1016/j.actbio.2017.01.076

Cited by 384 publications

(276 citation statements)

References 128 publications

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“…By contrast, the association of CaP granular form and an injectable polymer in our construct allowed the construct to perfectly fit the shape of the defect. Calcium phosphate was rapidly integrated into a newly formed bone network, just as we had expected . Moreover, the self‐setting properties of the superficial polymer contributed to maintain the granules in place into the defect .…”

Section: Discussionmentioning

confidence: 56%

“…Such scaffolds have yielded divergent results in clinical studies of human patients and warrant further investigation . Calcium phosphate (CaP) bone substitutes such as hydroxyapatite, tricalcium phosphate, and mixtures of these compounds are widely used as bone substitutes . Although they have been proposed as a subchondral base for biphasic constructs combined with HPMC or chitosan, none of the proposed biphasic constructs combined CaP granules and an injectable self‐setting polysaccharide polymer.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary evaluation of an osteochondral autograft, a prosthetic implant, and a biphasic absorbable implant for osteochondral reconstruction in a sheep model

et al. 2020

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Objective To determine the ability of three implants to enhance the healing of osteochondral defects: (1) a biphasic construct composed of calcium phosphate (CaP) and chitosan/cellulosic polymer, (2) a titanium‐polyurethane implant, and (3) an osteochondral autograft. Study design Experimental study. Animals Ten adult female sheep. Methods In five sheep, an 8‐mm diameter osteochondral defect was created on the medial femoral condyle of a stifle and filled with a synthetic titanium‐polyurethane implant. In five sheep, a similar defect was filled with an osteochondral autograft, and the donor site was filled with a biphasic construct combining CaP granules and a chitosan/cellulosic polymer. Sheep were monitored daily for lameness. Stifle radiographs and MRI were evaluated at 20 weeks, prior to animals being humanely killed. Surgical sites were evaluated with histology, microcomputed tomography, and scanning electron microscopy. Results Clinical outcomes were satisfactory regardless of the tested biomaterials. All implants appeared in place on imaging studies. Osteointegration of prosthetic implants varied between sites, with limited ingrowth of new bone into the titanium structure. Autografts and biphasic constructs were consistently well integrated in subchondral bone. All autografts except one contained a cartilage surface, and all biphasic constructs except one partially restored hyaline cartilage surface. Conclusion Biphasic constructs supported hyaline cartilage and subchondral bone regeneration, although restoration of the articular cartilage was incomplete. Clinical impact Biphasic constructs may provide an alternative treatment for osteochondral defects, offering a less invasive approach compared with autologous grafts and eliminating the requirement for a prosthetic implant.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Preliminary evaluation of an osteochondral autograft, a prosthetic implant, and a biphasic absorbable implant for osteochondral reconstruction in a sheep model

et al. 2020

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“…It is well known that resorption of pure HA is low compared with b-TCP and that biphasic CaP biomaterial degradation depends on percentage of HA and TCP content(Bouler, Pilet, Gauthier, & Verron, 2017;Samavedi, Whittington, & Goldstein, 2013). This could likely be explained by the longer time-points used in the present study.Descriptive histological analysis highlighted bone augmentation, supported by the presence of blood vessels, within the macropores in close contact with the pellet surfaces and associated to a limited presence of fibrous connective tissue, revealing CaP scaffolds osseointegration.…”

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confidence: 78%

In vitro and in vivo biocompatibility of calcium‐phosphate scaffolds three‐dimensional printed by stereolithography for bone regeneration

Guéhennec¹,

hede

Plougonven³

et al. 2019

J Biomedical Materials Res

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Stereolithography (SLA) is an interesting manufacturing technology to overcome limitations of commercially available particulated biomaterials dedicated to intra-oral bone regeneration applications. The purpose of this study was to evaluate the in vitro and in vivo biocompatibility and osteoinductive properties of two calcium-phosphate (CaP)-based scaffolds manufactured by SLA three-dimensional (3D) printing. Pellets and macro-porous scaffolds were manufactured in pure hydroxyapatite (HA) and in biphasic CaP (HA:60-TCP:40). Physico-chemical characterization was performed using micro X-ray fluorescence, scanning electron microscopy (SEM), optical interferometry, and microtomography (μCT) analyses. Osteoblast-like MG-63 cells were used to evaluate the biocompatibility of the pellets in vitro with MTS assay and the cell morphology and growth characterized by SEM and DAPI-actin staining showed similar early behavior. For in vivo biocompatibility, newly formed bone and biodegradability of the experimental scaffolds were evaluated in a subperiosteal cranial rat model using μCT and descriptive histology. The histological analysis has not indicated evidences of inflammation but highlighted close contacts between newly formed bone and the experimental biomaterials revealing an excellent scaffold osseointegration. This study emphasizes the relevance of SLA 3D printing of CaP-based biomaterials for intra-oral bone regeneration even if manufacturing accuracy has to be improved and further experiments using biomimetic scaffolds should be conducted. K E Y W O R D Sbone regeneration, bone scaffold, histology, microtomography, stereolithography

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“…Biodegradation has to happen in order to allow surrounding and/or ingrowth of tissues to restore their own function at the same rate that the biomaterial takes to degrade and vanish. A mix of bio‐resorbable ceramics with the more stable hydroxyapatite can control the gradual dissolution in the body . However, that is restricted to small defects (<3 cm), even if the osteogenic materials such as the well‐known BMP2 can stimulate the repair.…”

Section: Existing Types Of “Classical” Implanted Medical Devices Estamentioning

confidence: 99%

Tackling the Concept of Symbiotic Implantable Medical Devices with Nanobiotechnologies

Alcaraz

Cinquin

Martin

2018

Biotechnology Journal

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This review takes an approach to implanted medical devices that considers whether the intention of the implanted device is to have any communication of energy or materials with the body. The first part describes some specific examples of three different classes of implants, analyzed with regards to the type of signal sent to cells. Through several examples, the authors describe that a one way signaling to the body leads to encapsulation or degradation. In most cases, those phenomena do not lead to major problems. However, encapsulation or degradation are critical for new kinds of medical devices capable of duplex communication, which are defined in this review as symbiotic devices. The concept the authors propose is that implanted medical devices that need to be symbiotic with the body also need to be designed with an intended duplex communication of energy and materials with the body. This extends the definition of a biocompatible system to one that requires stable exchange of materials between the implanted device and the body. Having this novel concept in mind will guide research in a new field between medical implant and regenerative medicine to create actual symbiotic devices.

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Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response

Cited by 384 publications

References 128 publications

Preliminary evaluation of an osteochondral autograft, a prosthetic implant, and a biphasic absorbable implant for osteochondral reconstruction in a sheep model

Preliminary evaluation of an osteochondral autograft, a prosthetic implant, and a biphasic absorbable implant for osteochondral reconstruction in a sheep model

In vitro and in vivo biocompatibility of calcium‐phosphate scaffolds three‐dimensional printed by stereolithography for bone regeneration

Tackling the Concept of Symbiotic Implantable Medical Devices with Nanobiotechnologies

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