Biphasic amyloidosis: link between macular and lichenoid forms

Brownstein, Martin H.; Hashimoto, Ken; Greenwald, Gerald

doi:10.1001/archderm.106.3.419b

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“…There are several types, of which macular and lichenoid forms are the most frequent. The association of both types is termed biphasic amyloidosis 1 …”

Section: Reportmentioning

confidence: 99%

See 1 more Smart Citation

Widespread biphasic amyloidosis: response to acitretin

Hernández‐Núñez¹,

Daudén²,

Vega³

et al. 2001

Clinical and Experimental Dermatology

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We report a patient who presented with an intensely pruritic rash, with hyperpigmentation of the whole back and multiple hyperpigmented and hyperkeratotic papules over his forearms and lower extremities. Histologically, he showed deposits of amyloid that reacted positively with monoclonal antibodies against cytokeratins. The lesions were resistant to antihistamines and corticosteroids. Treatment with oral acitretin was started and great improvement of the lesion was noted; the patient became asymptomatic. We review the literature on the effect of retinoids in cutaneous amyloidosis.

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“…There are several types, of which macular and lichenoid forms are the most frequent. The association of both types is termed biphasic amyloidosis 1 …”

Section: Reportmentioning

confidence: 99%

“…Biphasic amyloidosis is the coexistence of both macular and lichenoid amyloidosis in the same patient 1 . It has been suggested that epidermal keratinocytes degenerate into amyloid k by an apoptotic mechanism that is not yet understood 2 .…”

Section: Reportmentioning

confidence: 99%