Biphasic actions of pentobarbital on synaptic transmission

Enflurane-Induced Burst Firing of Hippocampal Ca 1 Neurones

“…Effects on CA 1 pyramidal and dentate granule neurones were compared to determine whether the two populations of cortical neurones demonstrate different susceptibilities to anaesthetic-induced seizure activity. Such differential actions between CA 1 and dentate granule neurones would also provide support for selective, pathway-specific sites of action, as previously reported for other general anaesthetic agents (Roth, Bland and Maclver, 1983;Roth, Tan and Maclver, 1986).…”

“…DG neurones, in contrast, did not produce burst firing and the biphasic (excitation-depression) responses appeared to involve postsynaptic sites of action. The differential effects produced on DG and CA 1 neurones also provide further evidence that anaesthetic sites of action are selective (Roth, 1980) and pathway specific (Roth, Bland and Maclver, 1983).…”

Enflurane-Induced Burst Firing of Hippocampal Ca 1 Neurones

“…Effects on CA 1 pyramidal and dentate granule neurones were compared to determine whether the two populations of cortical neurones demonstrate different susceptibilities to anaesthetic-induced seizure activity. Such differential actions between CA 1 and dentate granule neurones would also provide support for selective, pathway-specific sites of action, as previously reported for other general anaesthetic agents (Roth, Bland and Maclver, 1983;Roth, Tan and Maclver, 1986).…”

“…DG neurones, in contrast, did not produce burst firing and the biphasic (excitation-depression) responses appeared to involve postsynaptic sites of action. The differential effects produced on DG and CA 1 neurones also provide further evidence that anaesthetic sites of action are selective (Roth, 1980) and pathway specific (Roth, Bland and Maclver, 1983).…”

Biological application of microelectrode arrays in drug discovery and basic research

“…LFP analysis has therefore been widely used to study synaptic plasticity or epileptic states, for example, see refs. [61,62,63,64,65,66]. Depending on the experiment, LFP waveforms are analyzed for the magnitude, spatial extent, and dynamics of the responses, the slope of the early responses, the latencies of individual components within the response, spatial patterns [67], etc.…”

Facilitatory action of etomidate and pentobarbital on recurrent inhibition in rat hippocampal pyramidal neurons

“…In the hippocampus, GABA facilitation is apparent not only as an increase in the amplitude of GABAergic IPSPs, but also as a prolongation of these inhibitory potentials (Alger and Nicoll, 1982b;Gage and Robertson, 1985;Nicoll et al, 1975;Roth et al, 1983). The mechanism underlying these effects appears likely to be the prolongation of the mean channel lifetime for GABA-activated chloride channels (Study and Barker, 1981).…”

Enflurane-Induced Burst Firing of Hippocampal Ca 1 Neurones

“…Effects on CA 1 pyramidal and dentate granule neurones were compared to determine whether the two populations of cortical neurones demonstrate different susceptibilities to anaesthetic-induced seizure activity. Such differential actions between CA 1 and dentate granule neurones would also provide support for selective, pathway-specific sites of action, as previously reported for other general anaesthetic agents (Roth, Bland and Maclver, 1983;Roth, Tan and Maclver, 1986).…”

“…DG neurones, in contrast, did not produce burst firing and the biphasic (excitation-depression) responses appeared to involve postsynaptic sites of action. The differential effects produced on DG and CA 1 neurones also provide further evidence that anaesthetic sites of action are selective (Roth, 1980) and pathway specific (Roth, Bland and Maclver, 1983).…”

Biological application of microelectrode arrays in drug discovery and basic research

“…LFP analysis has therefore been widely used to study synaptic plasticity or epileptic states, for example, see refs. [61,62,63,64,65,66]. Depending on the experiment, LFP waveforms are analyzed for the magnitude, spatial extent, and dynamics of the responses, the slope of the early responses, the latencies of individual components within the response, spatial patterns [67], etc.…”

Facilitatory action of etomidate and pentobarbital on recurrent inhibition in rat hippocampal pyramidal neurons

“…In the hippocampus, GABA facilitation is apparent not only as an increase in the amplitude of GABAergic IPSPs, but also as a prolongation of these inhibitory potentials (Alger and Nicoll, 1982b;Gage and Robertson, 1985;Nicoll et al, 1975;Roth et al, 1983). The mechanism underlying these effects appears likely to be the prolongation of the mean channel lifetime for GABA-activated chloride channels (Study and Barker, 1981).…”

Enflurane-Induced Burst Firing of Hippocampal Ca 1 Neurones

“…Effects on CA 1 pyramidal and dentate granule neurones were compared to determine whether the two populations of cortical neurones demonstrate different susceptibilities to anaesthetic-induced seizure activity. Such differential actions between CA 1 and dentate granule neurones would also provide support for selective, pathway-specific sites of action, as previously reported for other general anaesthetic agents (Roth, Bland and Maclver, 1983;Roth, Tan and Maclver, 1986).…”

“…DG neurones, in contrast, did not produce burst firing and the biphasic (excitation-depression) responses appeared to involve postsynaptic sites of action. The differential effects produced on DG and CA 1 neurones also provide further evidence that anaesthetic sites of action are selective (Roth, 1980) and pathway specific (Roth, Bland and Maclver, 1983).…”

Biological application of microelectrode arrays in drug discovery and basic research

“…LFP analysis has therefore been widely used to study synaptic plasticity or epileptic states, for example, see refs. [61,62,63,64,65,66]. Depending on the experiment, LFP waveforms are analyzed for the magnitude, spatial extent, and dynamics of the responses, the slope of the early responses, the latencies of individual components within the response, spatial patterns [67], etc.…”

Facilitatory action of etomidate and pentobarbital on recurrent inhibition in rat hippocampal pyramidal neurons

“…In the hippocampus, GABA facilitation is apparent not only as an increase in the amplitude of GABAergic IPSPs, but also as a prolongation of these inhibitory potentials (Alger and Nicoll, 1982b;Gage and Robertson, 1985;Nicoll et al, 1975;Roth et al, 1983). The mechanism underlying these effects appears likely to be the prolongation of the mean channel lifetime for GABA-activated chloride channels (Study and Barker, 1981).…”