Biotoxicity of paraquat to lung cells mediated by endoplasmic reticulum-mitochondria interactionMitochondrial dysfunction exposure mediates paraquat biotoxicity to lung tissue cells: The role of endoplasmic reticulum stress
Ping Xiao,
Shaohua Wu,
Zhiyong Wang
et al.
Abstract:Paraquat (PQ) has attracted much attention in public and human health due to its high toxicity and lethality. Apoptosis is one of the numerous biotoxin mechanisms of action of PQ, which was confirmed in our previous study with increased fibrosis of lung tissue induced by ferroptosis.However, the understanding of the mechanism of PQ-induced apoptosis from the perspective of organelles, especially inter-organelle interactions, is still scarce. In this study, we observed that a certain dose of PQ gavage induced o… Show more
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