Biosynthesis of the chromogen hermidin from Mercurialis annua L.

Ostrozhenkova, Elena; Eylert, Eva; Schramek, Nicholas; Golan‐Goldhirsh, Avi; Bacher, Adelbert; Eisenreich, Wolfgang

doi:10.1016/j.phytochem.2007.06.030

Cited by 15 publications

(8 citation statements)

References 29 publications

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“…Several studies have been published on the chemical composition of M. annua [15,43,78], M. perennis [5,10,12,14,15,16,79,80], and M. tomentosa [19], confirming the presence of a wide variety of phytochemicals in these species (Table S1). Some of them possess some interesting biological activity, which has already been extensively validated scientifically (Table 2).…”

Section: Discussionmentioning

confidence: 88%

Bioactive Phytochemicals from Mercurialis spp. Used in Traditional Spanish Medicine

Salas

Vázquez

Hortigón-Vinagre

et al. 2019

Plants

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Plants from the genus Mercurialis have a long history of use as herbal remedies in traditional Spanish medicine. The growing interest in the conservation of knowledge related to biodiversity has encouraged us to review the bioactive phytochemicals from the four most widespread Mercurialis species in the Iberian Peninsula (M. annua L., M. ambigua L., M. perennis L., and M. tomentosa L.). First, the medicinal uses of these four species throughout Spain were compiled, and then a bibliographical search on their chemical composition was conducted in an attempt to justify their reported traditional uses. We found that most of the medicinal uses of Mercurialis spp. are supported by scientific evidence. This includes its antidiabetic and antihypertensive properties attributable to the flavonoid rutin and narcissin, respectively; its benefits in the treatment of skin dark spots, attributable to mequinol; and its anti-inflammatory activity, attributable to scopoletin, kaempferol, squalene, and cycloartenol. This review contributes to the validation of the medicinal uses of Mercurialis spp. in Spain and provides some new avenues for further investigations on the biological activity of this interesting medicinal plant.

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Section: Discussionmentioning

confidence: 88%

Bioactive Phytochemicals from Mercurialis spp. Used in Traditional Spanish Medicine

Salas

Vázquez

Hortigón-Vinagre

et al. 2019

Plants

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“…As a consequence, very complex isotopologue mixtures arise. Only recently, the systematic deconvolution of the 13 C 13 C-coupling patterns in high-resolution NMR spectra allow the partial assignment and quantitative assessment of individual isotopologues in those product mixtures and two recent papers have used the 13 CO 2 technology for a detailed analysis of nicotine and hermidin biosynthesis in growing plants (Römisch-Margl et al, 2007;Ostrozhenkova et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

et al. 2010

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“…Using quantitative NMR spectroscopy, these isotopologue profiles can be assigned and attributed to biosynthetic pathways. Several recent examples have demonstrated the power of this experimental approach [49,50,51].…”

Section: Resultsmentioning

confidence: 99%

Biosynthesis of Panaxynol and Panaxydol in Panax ginseng

et al. 2013

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Abstract:The natural formation of the bioactive C 17 -polyacetylenes (−)-(R)-panaxynol and panaxydol was analyzed by 13 C-labeling experiments. For this purpose, plants of Panax ginseng were supplied with 13 CO 2 under field conditions or, alternatively, sterile root cultures of P. ginseng were supplemented with [U- 13C 6 ]glucose. The polyynes were isolated from the labeled roots or hairy root cultures, respectively, and analyzed by quantitative NMR spectroscopy. The same mixtures of eight doubly 13 C-labeled isotopologues and one single labeled isotopologue were observed in the C 17 -polyacetylenes obtained from the two experiments. The polyketide-type labeling pattern is in line with the biosynthetic origin of the compounds via decarboxylation of fatty acids, probably of crepenynic acid. The 13 C-study now provides experimental evidence for the biosynthesis of panaxynol and related polyacetylenes in P. ginseng under in planta conditions as well as in root cultures. The data also show that 13 CO 2 experiments under field conditions are useful to elucidate the biosynthetic pathways of metabolites, including those from roots.

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Biosynthesis of the chromogen hermidin from Mercurialis annua L.

Cited by 15 publications

References 29 publications

Bioactive Phytochemicals from Mercurialis spp. Used in Traditional Spanish Medicine

Bioactive Phytochemicals from Mercurialis spp. Used in Traditional Spanish Medicine

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

Biosynthesis of Panaxynol and Panaxydol in Panax ginseng

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