A great variety of sialic acids (Sia) is known to occur in animals and some microorganisms. Sia significantly contribute to the enormous structural diversity of complex carbohydrates. We are trying to understand the multifacetted metabolic and biological effects of these acidic monosaccharides in general and of the specific roles of their diRerent substituents on physiological and pathological processes. In this respect, the main topics presently studied are cell protection, fertilization, differentiation, cell adhesion, immunology, inflammation and tumour growth. Although it is the present opinion that the structures of most Sia have been elucidated, the enzymes involved in their metabolism need more attention. The properties and structures of the catabolic enzymes sialidase, sialate lyase and sialate esterases have been studied, but on the anabolic site, only the CMP-N-acetylneuraminic acid hydroxylase and sialate-8-0-methyltransferase have been purified to homogeneity, and only the gene structure of the hydroxylase was investigated. It is challenging to focus on these enzymes, especially also on the widespread sialate 0-acetyltransferases, in order to better understand the regulation of the expression of diverse Sia under variable biological conditions.
Occurrence and BiosynthesisSialic acids (Sia) are a family of monosaccharides comprising about 40 members which can be considered as derivatives of 2-keto-3-deoxy-nononic acid (Kdn), the 5-amino derivative representing the long-known neuraminic acid [ 11. However, Kdn formally is a 5-desamino-5-hydroxy-neuraminic acid. Thus, all sialic acids are derivatives of neuraminic acid with different substituents at the amino or hydroxyl Carbohydrates in Chemistry and Biology