Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Bai, Wubin; Shin, Jiho; Fu, Ruxing; Kandela, Irawati; Lü, Di; Ni, Xiaoyue; Park, Yoonseok; Liu, Zhonghe; Hang, Tao; Wu, Di; Liu, Yonghao; Haney, Chad R.; Stepien, Iwona; Yang, Quansan; Zhao, Jie; Nandoliya, Khizar; Zhang, Hao; Sheng, Xing; Yin, Lan; MacRenaris, Keith W.; Brikha, Anlil; Aird, Fraser; Pezhouh, Maryam Kherad; Hornick, Jessica E.; Zhou, Weidong; Li, Jinghua

doi:10.1038/s41551-019-0435-y

Cited by 110 publications

(132 citation statements)

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“…The logarithmic dependence of the prompt gamma production on the oxygen, carbon, and calcium concentrations, not measurable by NMRS, will be further investigated with PIBS. There are also very recent advances for real-time monitoring of internal physiological processes by means of spectroscopic bioresorbable photonic devices that can also measure oxygenation levels and calcium concentration 56 .…”

Section: Discussionmentioning

confidence: 99%

PIBS: Proton and ion beam spectroscopy for in vivo measurements of oxygen, carbon, and calcium concentrations in the human body

Martins

Bello

Ackermann

et al. 2020

Sci Rep

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Proton and ion beam therapy has proven to benefit tumour control with lower side-effects, mostly in paediatrics. Here we demonstrate a feasible technique for proton and ion beam spectroscopy (PIBS) capable of determining the elemental compositions of the irradiated tissues during particle therapy. This follows the developments in prompt gamma imaging for online range verification and the inheritance from prompt gamma neutron activation analysis. Samples of water solutions were prepared to emulate varying oxygen and carbon concentrations. the irradiation of those samples and other tissue surrogate inserts by protons and ion beams under clinical conditions clearly showed a logarithmic relationship between the target elemental composition and the prompt gamma production. This finding is in line with the known logarithmic dependence of the pH with the proton molar concentration. Elemental concentration changes of 1% for calcium and 2% for oxygen in adipose, brain, breast, liver, muscle and bone-related tissue surrogates were clearly identified. Real-time in vivo measurements of oxygen, carbon and calcium concentrations will be evaluated in a pre-clinical and clinical environment. This technique should have an important impact in the assessment of tumour hypoxia over the course of several treatment fractions and the tracking of calcifications in brain metastases. The analysis of the elemental compositions of the human body by means of irradiated particles was first described by Anderson et al. in 1964 1,2. That technique was coined as in vivo neutron activation analysis 1. That breakthrough gave rise to the measurements of total body hydrogen 3,4 , carbon 5 , nitrogen 6 , calcium and sodium 7,8 , and localized measurements of chlorine 9 and cadmium 6,10. The activated elements were identified because of their decay at different rates or because they emitted gamma-rays of different energy 1. The latter was further developed and nominated as prompt gamma in vivo neutron analysis (PGIVNA or IVNAA). The evaluation of total body protein by IVNAA 11 had a major impact in intensive care patients 12 , thus saving several billions of dollars annually round the World 13. A comprehensive review of in vivo experimental methods to determine the composition of the human body has been carried out by Sutcliffe 14 and Ellis & Eastman 15. The IVNAA relied either on high energy resolution germanium detectors (HPGe) for tracking calcium, cadmium and chlorine or by thick sodium iodide NaI(Tl) detectors for determining total body hydrogen and nitrogen. This technique was developed close to nuclear reactors, particle accelerators or radioisotope neutron sources. Many facilities, such as the ones at Birmingham 16 and Brookhaven 4,17 , were fully designed with the purpose of studying the prompt activation for the spectroscopy of neutron activated elements. More recently, new techniques have emerged for the detection of heavier elements in human organs 18-20. However, neutron therapy, although popular in the 70 s and 80 s, still offers low mar...

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Section: Discussionmentioning

confidence: 99%

PIBS: Proton and ion beam spectroscopy for in vivo measurements of oxygen, carbon, and calcium concentrations in the human body

Martins

Bello

Ackermann

et al. 2020

Sci Rep

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“…Copyright 2015, American Chemical Society. b) Top‐Left: Sketch of the structure of the bioresorbable fiber‐photodetector system . Top‐Middle: Optical microscope image of a fabricated device with RGB detector.…”

Section: Implanted Bioresorbable Systemsmentioning

confidence: 99%

Section: Implanted Bioresorbable Systemsmentioning

confidence: 99%

“…Very recently, a bioresorbable optoelectronic system was reported by Bai et al, consisting of an optical fiber used to deliver light, a photodetector for generating electrical signals in response to transmitted light, and electrodes for electrical interconnection of the photodetector to external measurement setups (Figure b). The system was assembled into a shape that resembled hypodermic needles (600 µm wide, 160 µm thick, and several mm long) to facilitate minimally invasive implantation.…”

Section: Implanted Bioresorbable Systemsmentioning

confidence: 99%

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Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.

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“…Here, bioresorbable constituent materials minimize inflammatory responses and eliminate the need for secondary surgical extraction. [ 9–13 ] Recent examples include not only pressure but also temperature sensors for the intracranial space; [ 14–16 ] photonic devices for monitoring physiological status and neural activity; [ 17 ] wireless electronic systems for neuroregenerative therapy; [ 18 ] platforms for spatiotemporal mapping of electrical activity from the cerebral cortex; [ 19 ] drug release vehicles for infection abatement; [ 20 ] and systems for measuring blood flow. [ 21 ] Realizing consistent performance throughout a clinically relevant monitoring period with devices that bioresorb completely over slightly longer timescales represents an important goal.…”

Section: Introductionmentioning

confidence: 99%

Materials, Mechanics Designs, and Bioresorbable Multisensor Platforms for Pressure Monitoring in the Intracranial Space

Yang

Lee

Xue

et al. 2020

Adv Funct Materials

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Pressures in the intracranial, intraocular, and intravascular spaces are important parameters in assessing patients with a range of conditions, of particular relevance to those recovering from injuries or from surgical procedures. Compared with conventional devices, sensors that disappear by natural processes of bioresorption offer advantages in this context, by eliminating the costs and risks associated with retrieval. A class of bioresorbable pressure sensor that is capable of operational lifetimes as long as several weeks and physical lifetimes as short as several months, as combined metrics that represent improvements over recently reported alternatives, is presented. Key advances include the use of 1) membranes of monocrystalline silicon and blends of natural wax materials to encapsulate the devices across their top surfaces and perimeter edge regions, respectively, 2) mechanical architectures to yield stable operation as the encapsulation materials dissolve and disappear, and 3) additional sensors to detect the onset of penetration of biofluids into the active sensing areas. Studies that involve monitoring of intracranial pressures in rat models over periods of up to 3 weeks demonstrate levels of performance that match those of nonresorbable clinical standards. Many of the concepts reported here have broad applicability to other classes of bioresorbable technologies.

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Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity

Cited by 110 publications

References 50 publications

PIBS: Proton and ion beam spectroscopy for in vivo measurements of oxygen, carbon, and calcium concentrations in the human body

PIBS: Proton and ion beam spectroscopy for in vivo measurements of oxygen, carbon, and calcium concentrations in the human body

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Materials, Mechanics Designs, and Bioresorbable Multisensor Platforms for Pressure Monitoring in the Intracranial Space

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