Biopathology of Ovarian Mesothelium

Nicosia, Santo V.; Saunders, Beatriz O.; Acevedo‐Duncan, Mildred; Setrakian, Sebouh; DeGregorio, Richard

doi:10.1007/978-1-4615-3944-5_18

Cited by 26 publications

(32 citation statements)

References 49 publications

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“…18 The findings of the current study indicate that the HOSE is not morphogenetically quiescent, in agreement with previous histologic, immunohistochemical, and ultrastructural studies. 2,3,19 These studies have demonstrated that the HOSE undergoes a series of events during life, including the following: 1) a variable modulation from a monostratified and columnar to a pseudostratified and low-columnar morphology; 2) the formation of nests, invaginations or crypts, and inclusion cysts; 3) the development of papillary processes of various sizes and complexities; 4) a metaplastic tendency toward mü llerian phenotypes, including ciliated or tubal, endometrioid, and endocervical or mucinous; and 5) discrete cytologic alterations reflecting function, cell cycle events, reproductive status, and aging. 2,17 The current study identified two HOSE cell populations with morphometric features similar to those described in a previous scanning electron microscopy study of ovarian biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…11 Ciliogenesis, an estrogen-driven phenomenon, also is observed in metaplastic HOSE cells as well as in benign or low malignant potential HOSE neoplasms. 2 Finally, the HOSE of experimental animals is highly proliferative and papillary when exposed to estrogens but monostratified and atrophic after progesterone exposure. 21 In addition, gonadotropins activate intraovarian carcinogenic enzymes and stimulate or inhibit HOSE growth.…”

Section: Discussionmentioning

confidence: 99%

“…30 Most investigators agree that the HOSE is the source of this gynecologic malignancy, although others have suggested a similar role for the secondary mü llerian system at large. 2,31,32 Investigators have attempted to identify a continuum of morphologic or molecular lesions in native ovaries from atypical HOSE lesions, through cystadenomas and borderline neoplasms to frankly invasive carcinomas. 33 Atypical or dysplastic HOSE lesions have been described in ovaries prophylactically removed in otherwise healthy siblings of patients with ovarian carcinoma, as well as in ovaries removed from patients with contralateral HOSE cancer, endometrial carcinoma, and benign extraovarian disease, including polycystic ovaries.…”

Section: Discussionmentioning

confidence: 99%

“…Since 1967, cul-de-sac puncture has been used in the diagnosis of early-stage ovarian carcinoma, and since 1997, brushings have been used to harvest benign HOSE cells for experimental studies. 9,52 The current study defines the baseline cytomorphology of laparoscopically harvested HOSE cells in a population of women with normal or benign ovaries. It remains to be determined whether this 'ovarian Pap' test is acceptable, diagnostically and clinically relevant, and able to provide cellular samples amenable to molecular studies.…”

Section: Discussionmentioning

confidence: 99%

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Cytology of human ovarian surface epithelial brushings

Nicosia¹,

Wilbanks²,

Saunders³

et al. 2003

Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cytology of human ovarian surface epithelial brushings

Nicosia¹,

Wilbanks²,

Saunders³

et al. 2003

Cancer

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“…Epithelium is present in the ovary, in form of modified pelvic mesothelium, that covers the mammalian female gonads peritoneal aspect [1], also referred to as the ovarian surface epithelium (OSE) [2], ovarian mesothelium (OM) [1] or normal ovarian epithelium (NOE) [3]. It has been previously described as germinal epithelium, as it was believed to be the source of germ cells.…”

Section: Ovarian Epithelial Cellsmentioning

confidence: 99%

Does migrative and proliferative capability of epithelial cells reflect cellular developmental competence?

Jankowski

Dyszkiewicz-Konwińska

Budna

et al. 2018

Medical Journal of Cell Biology

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Mammalian epithelial and epithelial-like cells are significantly involved in various processes associated with tissue development, differentiation and oncogenesis. Because of that, high number of research is focused on identifying cells that express stem-like or progenitor characteristics. Identifying such cells and recognizing their specific markers, would open new clinical opportunities in transplantology and oncology. There are several epithelia characterized by their ability to rapidly proliferate and/or differentiate. Due to their function or location they are subject to cyclic changes involving processes of apoptosis and regeneration. Literature presenting well-structured studies of these types of epithelia was analyzed in order to compare various results and establish if epithelial cells' migrative and proliferative ability indicates their stemness potential. Endometrial, ovarian, oviductal and oral mucosal epithelia were analyzed with most of the publications delivering relatively unified results. The ability to rapidly proliferate/ differentiate usually indicated the presence of some kind of stem/stem-like/progenitor cells. Most of the papers focused on pinpointing the exact location of these kind of cells, or analyzing specific markers that would be used for their future identification. There have also been substantial proportion of research that focused on discovering growth factors or intercellular signals that induced proliferation/differentiation in analyzed epithelia. Most of the research provided valuable insights into the modes of function and characteristics of the analyzed tissue, outlining the importance of such study for the possible clinical application of in vitro derived cell cultures.

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Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: Serous and mucinous tumors exhibit distinctive patterns of expression

et al. 1999

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Expression of blood group–related carbohydrate antigens was examined in frozen sections from a series of ovarian carcinomas of different histological types using an indirect immunoperoxidase technique. Antigenic specificities belonging to the O(H) and Lewis blood group families (H‐1, H‐2, Lea, sLea, Lex, sLex, Leb and Ley) or the mucin‐core family (Tn, sTn and TF) were studied. A distinct difference in antigen expression between mucinous and other ovarian carcinomas (serous and endometrioid) was observed. Specifically, mucinous tumors tended to express sTn, Lea and sLea strongly and homogeneously, whereas serous and endometrioid tumors rarely expressed these specificities and, in contrast, expressed Ley and H type 2 antigen strongly. When expressed in serous tumors, sTn was usually distributed in a heterogeneous pattern, whereas sTn expression in mucinous tumors was much more homogeneous. The distribution of Ley in serous tumors was noticeably homogeneous. H‐1, Lex, sLex,, Leb , TF and Tn specificities were rarely expressed in any type of ovarian carcinoma. Our results provide further support for the different histogenesis of mucinous and non‐mucinous tumors and indicate alternative differentiation pathways for the 3 pathological subtypes of ovarian tumor. They also provide the basis for the choice of carbohydrate antigens for active and passive immunotherapy of ovarian carcinomas. Int. J. Cancer 81:193–198, 1999. © 1999 Wiley‐Liss, Inc.

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Biopathology of Ovarian Mesothelium

Cited by 26 publications

References 49 publications

Cytology of human ovarian surface epithelial brushings

Cytology of human ovarian surface epithelial brushings

Does migrative and proliferative capability of epithelial cells reflect cellular developmental competence?

Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: Serous and mucinous tumors exhibit distinctive patterns of expression

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