Biomonitoring of gasoline station attendants exposed to benzene: Effect of gender

Moro, Ângela M.; Brucker, Natália; Charão, Mariele Feiffer; Baierle, Marília; Saüer, Elisa; Göethel, Gabriela; Barth, Anelise; Nascimento, Sabrina; Gauer, Bruna; Durgante, Juliano; Amaral, Beatriz S.; Neto, Francisco R. Aquino; Gioda, Adriana; Garcia, Solange Cristina

doi:10.1016/j.mrgentox.2016.11.002

Cited by 41 publications

(26 citation statements)

References 52 publications

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“…Whereas, Total bilirubin had no significantly different between exposed and controls. The significantly increase in ALT and AST is in line with other studies conducted in Egypt, Nigeria, Turkey, Palestine, India, and Brazil [13,[30][31][32][33][34]. This observation may be due to the fact that hydrocarbons which are a major component of petroleum products that are metabolized in the liver by CYP450 2E1 oxidative pathways which contribute to the production of free radicals and quinine metabolites such as phenol, hydroquinone, benzoquinone;1,2,4 benzenetriol [17].…”

Section: Plos Onesupporting

confidence: 89%

Assessment of liver and renal function tests among gasoline exposed gas station workers in Mekelle city, Tigray region, Northern Ethiopia

et al. 2020

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Background Volatile organic compounds such as gasoline and other fuels are associated with a wide variety of deleterious health effects including liver and kidney diseases. Gasoline station workers are exposed to a mixture of hydrocarbons during dispensing. However, no published studies investigated the liver and renal function tests of gasoline station workers in Ethiopia. Therefore the aim of this study was to assess liver and renal function tests among gasoline station workers. Method A comparative cross sectional study was conduct from January 2018 to April 2018 at Mekelle city, Tigray region, Northern Ethiopia. Liver and renal function tests were analyzed on gasoline exposed (n = 43) and controls (n = 47) by Pentra C400 automated clinical chemistry analyzer. Student independent t-test and one way-ANOVA statistical methods were employed using SPSS Ver23. P-value < 0.05 was regarded as statistically significant. Result The mean level of ALT, AST, Urea, creatinine, and uric acid was significantly higher among gasoline stations workers when compared to control study participants. There was also a significant increase in ALT, AST, Urea, creatinine and uric acid among gasoline stations with above 6 years exposure when compared with those exposed for �2 and3-6years. Conclusion These findings suggest that increasing liver and renal parameters may be associated with exposure to gasoline and it is dependent on time of exposure to gasoline.

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Section: Plos Onesupporting

confidence: 89%

Assessment of liver and renal function tests among gasoline exposed gas station workers in Mekelle city, Tigray region, Northern Ethiopia

et al. 2020

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“…On the other hand, an association between urinary benzene metabolite levels and insulin resistance in elderly adults demonstrated a stronger relationship in men than in women [23]. Furthermore, sex differences were observed upon occupational benzene exposure, particularly effects related to biotransformation of benzene to t,t-MA and hematological parameters [58]. Similarly, benzene exposure rapidly induced hypothalamic and hepatic expression of benzene metabolite, CYP2E1 specifically in male mice, supporting the gender differences in benzene metabolism.…”

Section: Discussionmentioning

confidence: 79%

Acarbose Protects From Central and Peripheral Metabolic Imbalance Induced by Benzene Exposure

Debarba

Mulka

Lima

et al. 2020

Preprint

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Abbreviations:CNS, central nervous system; ARC, arcuate nucleus of the hypothalamus; DMH, dorsomedial hypothalamic nucleus; LHA, lateral hypothalamus; PVH, paraventricular hypothalamic nucleus; AbstractBenzene is a well-known human carcinogen that is one of the major components of air pollution. Sources of benzene in ambient air include cigarette smoke, e-cigarettes vaping and evaporation of benzene containing petrol processes. While carcinogenic effects of benzene exposure have been well studied, less is known about metabolic effects of benzene exposure.We show that chronic exposure to benzene at low levels induces severe metabolic imbalance in a sex-specific manner, which is associated with hypothalamic inflammation and endoplasmic reticulum (ER) stress. Benzene exposure rapidly activates hypothalamic ER stress and neuroinflammatory responses in male mice, while pharmacological inhibition of ER stress response by inhibiting IRE1α-XBP1 pathway significantly alleviates benzene-induced glial inflammatory responses. Additionally, feeding mice with Acarbose, a clinically available anti-diabetes drug, protected against benzene induced central and peripheral metabolic imbalance. Acarbose imitates the slowing of dietary carbohydrate digestion, suggesting that choosing a diet with a low glycemic index might be a potential strategy for reducing the negative metabolic effect of chronic exposure to benzene for smokers or for people living/working in urban environments with high concentrations of exposure to automobile exhausts.

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“…Physiological differences between males and females may account for variable toxicological responses to poisons [35]. Studies have shown that females have a higher percentage of body fat, gender alters the biotransformation of benzene, and women may be more susceptible to blood alterations caused by benzene exposure [36]. Cigarette smoking is one of the most important sources of benzene, and studies have demonstrated that smoking may affect the associations of benzene exposure with blood cell counts [23].…”

Section: Discussionmentioning

confidence: 99%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Zhang

Deng

et al. 2020

BMC Public Health

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Background: Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods: To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and measured their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG), and occurrence of fatty liver. Results: The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) (P-overall < 0.001, and P-nonlinear < 0.015), as well as positive linear associations and r-shaped nonlinear relationships of continuous fat content indices with erythroid-related hematological parameters (P-overall ≤0.005). We also observed modification effects of fat content on the associations between benzene exposure and erythroid-related hematological parameters, with workers of lower or higher BF% and TG more sensitive to benzene-induced elevation of MCHC (P interaction = 0.021) and benzene-induced decrease of HCT (P interaction = 0.050), respectively. We also found that some erythroid-related hematologic parameters differed between subgroups of workers with different SPMA levels and fat content combination.

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Biomonitoring of gasoline station attendants exposed to benzene: Effect of gender

Cited by 41 publications

References 52 publications

Assessment of liver and renal function tests among gasoline exposed gas station workers in Mekelle city, Tigray region, Northern Ethiopia

Assessment of liver and renal function tests among gasoline exposed gas station workers in Mekelle city, Tigray region, Northern Ethiopia

Acarbose Protects From Central and Peripheral Metabolic Imbalance Induced by Benzene Exposure

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

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