Biomimetic proteolipid vesicles for targeting inflamed tissues

Molinaro, Roberto; Corbo, Claudia; Martinez, Jonathan O.; Taraballi, Francesca; Evangelopoulos, Michael; Minardi, Silvia; Yazdi, Iman K.; Zhao, Picheng; Rosa, Enrica De; Sherman, Michael B; Vita, Alessandro De; Furman, Naama E. Toledano; Wang, X.; Parodi, Alessandro; Tasciotti, Ennio

doi:10.1038/nmat4644

Cited by 350 publications

(365 citation statements)

References 52 publications

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“…Other than stem cells, endothelial cells and white blood cells have also been employed to create nanodelivery vesicles capable of unique functions [148,149]. In a recent example, the proteins derived from the plasma membrane of leukocytes were mixed with synthetic lipids, and the resulting leukosomes were able to deliver dexamethasone to treat inflamed vasculature [150]. …”

Section: Cell Membrane-based Nanostructuresmentioning

confidence: 99%

Cell membrane-derived nanomaterials for biomedical applications

et al. 2017

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The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self-identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications.

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Section: Cell Membrane-based Nanostructuresmentioning

confidence: 99%

Cell membrane-derived nanomaterials for biomedical applications

et al. 2017

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“…[156] Another example for a bioinspired particle coating to overcome biological barriers and improve biodistribution is proteolipid vesicles (i.e., 'leukosomes') to target inflamed tissue. [157] Stealth particles with low protein binding not only improved blood circulation and biodistribution, but retained targeting ability in the presence of complex biological environments.…”

Section: Reducing Protein Adsorptionmentioning

confidence: 99%

Particle Targeting in Complex Biological Media

Dai

Bertleff‐Zieschang

Braunger

et al. 2017

Adv Healthcare Materials

100

102

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Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with specific cells and tissues, and accumulate at desired target sites, reducing side effects and improve overall efficacy in applications such as vaccination and drug delivery. However, when targeted particles enter a complex biological environment, the adsorption of biomolecules and the formation of a surface coating (e.g., a protein corona) changes the properties of the carriers and can render their behavior unpredictable. For this reason, it is of importance to consider the potential challenges imposed by the biological environment at the early stages of particle design. This review describes parameters that affect the targeting ability of particulate drug carriers, with an emphasis on the effect of the protein corona. We highlight strategies for exploiting the protein corona to improve the targeting ability of particles. Finally, we provide suggestions for complementing current in vitro assays used for the evaluation of targeting and carrier efficacy with new and emerging techniques (e.g., 3D models and flow‐based technologies) to advance fundamental understanding in bio‐nano science and to accelerate the development of targeted particles for biomedical applications.

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“…For example, surface proteins from leukocyte plasma membrane were extracted, and then the proteins were incorporated onto the liposome surface (58). The vesicles, so-called leukosomes displayed targeting ability to inflamed endothelia, and retained physicochemical properties of liposomes.…”

Section: Targeting Inflamed Endotheliummentioning

confidence: 99%

Targeting Inflammatory Vasculature by Extracellular Vesicles

Wang

Dong

Gao

et al. 2018

AAPS J

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Extracellular vesicles (EVs) are cell membrane-derived compartments that regulate physiology and pathology in the body. Naturally secreted EVs have been well studied in their biogenesis and have been exploited in targeted drug delivery. Due to the limitations on production of EVs, nitrogen cavitation has been utilized to efficiently generate EV-like drug delivery systems used in treating inflammatory disorders. In this short review, we will discuss the production and purification of EVs, and we will summarize what technologies are needed to improve their production for translation. We describe the drug-loading processes in EVs and their applications as drug delivery systems for inflammatory therapies, focusing on a new type of EVs made from neutrophil membrane using nitrogen cavitation.

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Biomimetic proteolipid vesicles for targeting inflamed tissues

Cited by 350 publications

References 52 publications

Cell membrane-derived nanomaterials for biomedical applications

Cell membrane-derived nanomaterials for biomedical applications

Particle Targeting in Complex Biological Media

Targeting Inflammatory Vasculature by Extracellular Vesicles

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