Biomimetic Lipid Polymer Nanoparticles for Drug Delivery

Carmona-Ribeiro, Ana Maria

doi:10.1007/978-1-0716-0319-2_4

Cited by 15 publications

(12 citation statements)

References 44 publications

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“…Destabilization of the membrane electrochemical potential allowed AMP insertion in the plasmatic membrane of the bacteria, its rupture and bacterial cell death [ 7 , 9 , 51 , 52 ]. Major issues against AMPs applications have been related to AMPs’ toxicity to eukaryotic cells, poor stability in vivo with eventual degradation during transportation to their target cells and organs [ 32 , 51 , 53 , 54 ].…”

Section: Asa With Ampsmentioning

confidence: 99%

Section: Asa With Ampsmentioning

confidence: 99%

“…The most important types of carriers for AMPs were liposomes [64,67,69,70,101], nanostructured lipid carriers [104], lyotropic lipid phases (cubic and hexagonal) [105], lipid nanodisks, and bilayer fragments [10,12], NPs of several types such as biomimetic [20,28,32,68], polymeric [61,89,106], magnetic [107,108], metal−AMPs designed as metallodrugs with nuclease, and protease activity [109] or silver co−spinned with nisin in The relative high burden of methicillin−resistant S. aureus (MRSA) has been a major concern in healthcare; vancomycin, a glycopeptide antibiotic inhibiting cell wall biosynthesis, has remained the drug of choice for treatment of severe MRSA infections for many years. Unfortunately, vancomycin−resistant S. aureus strains have been disclosed in the 1990s; their polygenic molecular basis of resistance was due to stepwise mutations in genes encoding molecules predominantly involved in cell envelope biosynthesis [91].…”

Section: Asa With Amps For Preserving Activity and Reducing Toxicitymentioning

confidence: 99%

“…Components in ASA materials can be organic, inorganic or hybrid, acting as antibacterial agents themselves and/or as carriers for timed−release of the antibacterial agent(s). ASA formulations have included coatings [ 21 , 22 , 23 , 24 ], functionalized surfaces [ 25 , 26 ], NPs [ 14 , 17 , 27 , 28 , 29 , 30 , 31 , 32 ], surfactant and/or lipid dispersions such as vesicles, liposomes, lipid disks [ 12 , 13 , 20 , 33 ], hydrogels [ 34 , 35 , 36 ], wound dressings [ 37 ], dentistry materials [ 38 ], etc.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Polymer−Based Assemblies: A Review

Carmona-Ribeiro

Araújo

2021

IJMS

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An antimicrobial supramolecular assembly (ASA) is conspicuous in biomedical applications. Among the alternatives to overcome microbial resistance to antibiotics and drugs, ASAs, including antimicrobial peptides (AMPs) and polymers (APs), provide formulations with optimal antimicrobial activity and acceptable toxicity. AMPs and APs have been delivered by a variety of carriers such as nanoparticles, coatings, multilayers, hydrogels, liposomes, nanodisks, lyotropic lipid phases, nanostructured lipid carriers, etc. They have similar mechanisms of action involving adsorption to the cell wall, penetration across the cell membrane, and microbe lysis. APs, however, offer the advantage of cheap synthetic procedures, chemical stability, and improved adsorption (due to multipoint attachment to microbes), as compared to the expensive synthetic routes, poor yield, and subpar in vivo stability seen in AMPs. We review recent advances in polymer−based antimicrobial assemblies involving AMPs and APs.

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Section: Asa With Ampsmentioning

confidence: 99%

Section: Asa With Ampsmentioning

confidence: 99%

Section: Asa With Amps For Preserving Activity and Reducing Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Polymer−Based Assemblies: A Review

Carmona-Ribeiro

Araújo

2021

IJMS

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“…Synthetic biocompatible polymers such as PMMA were also hybridized with cationic polymers or cationic lipids or surfactants [ 160 , 161 , 162 , 163 , 210 , 211 , 212 , 213 ]. In summary, a variety of model hybrid and cationic delivery systems are already available to combine with a myriad of oppositely charged antigens for vaccine design [ 25 , 163 , 214 , 215 ].…”

Section: Hybrid Cationic Assemblies Of Biocompatible Polymer/catiomentioning

confidence: 99%

Cationic Nanostructures for Vaccines Design

Carmona-Ribeiro

Betancourt

2020

Biomimetics

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Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a stimulator of humoral response such as an inflammasome activator. Most antigens are negatively charged and combine well with oppositely charged adjuvants. This explains the paramount importance of studying a variety of cationic supramolecular assemblies aiming at the optimal activity in vivo associated with adjuvant simplicity, positive charge, nanometric size, and colloidal stability. In this review, we discuss the use of several antigen/adjuvant cationic combinations. The discussion involves antigen assembled to 1) cationic lipids, 2) cationic polymers, 3) cationic lipid/polymer nanostructures, and 4) cationic polymer/biocompatible polymer nanostructures. Some of these cationic assemblies revealed good yet poorly explored perspectives as general adjuvants for vaccine design.

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Physicochemical properties and bio‐interfacial interactions of surface modified PDLLA‐PAMAM linear dendritic block copolymers

Simms

Chandrasiri

et al. 2021

Journal of Polymer Science

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Here, we demonstrate the applicability of self‐assembling linear‐dendritic block copolymers (LDBCs) and their nanoaggregates possessing varied surfaces as therapeutic nanocarriers. These LDBCs are comprised of a hydrophobic, linear polyester chemically coupled to a hydrophilic dendron polyamidoamine (PAMAM)—the latter of which acts as the surface of the self‐assembled nanoaggregate in aqueous media. To better understand how surface charge density affects the overall operability of these nanomaterials, we modified the nanoaggregate surface to yield cationic (NH3+), neutral (OH), and anionic (COO−) surfaces. The effect of these modifications on the physicochemical properties (i.e., size, morphology, and surface charge density), colloidal stability, and cellular uptake mechanism of the polymeric nanocarrier were investigated. This comparative study demonstrates the viability of nanoaggregates formed from PDLLA‐PAMAM LDBCs to serve as nanocarriers for applications in drug delivery.

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Biomimetic Lipid Polymer Nanoparticles for Drug Delivery

Cited by 15 publications

References 44 publications

Antimicrobial Polymer−Based Assemblies: A Review

Antimicrobial Polymer−Based Assemblies: A Review

Cationic Nanostructures for Vaccines Design

Physicochemical properties and bio‐interfacial interactions of surface modified PDLLA‐PAMAM linear dendritic block copolymers

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