Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers

Zhang, Wei; Luo, Xiao; Niu, Li Na; Yang, Hong; Yiu, Cky; Wang, Tian Da; Zhou, Li; Mao, Jing; Huang, Cui; Pashley, David H.; Tay, Franklin R.

doi:10.1038/srep11199

Cited by 35 publications

(20 citation statements)

References 42 publications

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“…Many strategies have been developed to further promote the remineralization of dentin. Tay and co-workers have developed the strategies of collagen phosphorylation [114][115][116], silicified-collagen [117], and mesoporous silica carriers of ACP [118]. Tang and co-workers have found many small additives that promote the remineralization of dentin, such as glutamic acid [119] and glutaraldehyde [120].…”

Section: Biomimetic Organic Matrixmentioning

confidence: 99%

Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

et al. 2018

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Many biomineralization systems start from transient amorphous precursor phases, but the exact crystallization pathways and mechanisms remain largely unknown. The study of a well-defined biomimetic crystallization system is key for elucidating the possible mechanisms of biomineralization and monitoring the detailed crystallization pathways. In this review, we focus on amorphous phase mediated crystallization (APMC) pathways and their crystallization mechanisms in bio-and biomimetic-mineralization systems. The fundamental questions of biomineralization as well as the advantages and limitations of biomimetic model systems are discussed. This review could provide a full landscape of APMC systems for biomineralization and inspire new experiments aimed at some unresolved issues for understanding biomineralization.

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Section: Biomimetic Organic Matrixmentioning

confidence: 99%

Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

et al. 2018

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“…The PA-ACP@AF-eMSN employed in the present study have several distinct advantages over the non-expanded MSN carrier that was presented in the authors’ previous work [31]. Firstly, large differences in surface area, pore volume and pore size were observed among the eMSN, AF-eMSN, and PA-ACP@AF-eMSN.…”

Section: Resultsmentioning

confidence: 68%

“…After amine functionalization, the BET specific surface area was reduced from 394.14 to 323.80 m 2 /g, while the pore volume decreased from 1.18 to 0.61 cm 3 /g. Their pore size was reduced from 14.8 to 8.1 nm (Fig.1g), which is still larger than the mean pore size (< 4 nm) of conventional non-amine-functionalized MCM-41 MSN with hexagonal pore architecture [31]. This renders the AF-eMSN more favorable for loading biomineralization precursors.…”

Section: Resultsmentioning

confidence: 94%

“…An image of an ultrathin section of epoxy resin-embedded eMSN prepared with an ultramicrotome (Fig.1c) showed that most of the mesopores were arranged radially from the center to the surface of nanoparticle. Unlike non-expanded MSN that displayed short-range order of their internal pore architecture that is manifested as several definitive Bragg diffraction peaks in small-angle XRD [31], no typical diffraction peak was identified in the small-angle XRD pattern of eMSN (Fig.1d). This indicates that the original hexagonal pore order in MCM-41 type MSN was lost following TMB-directed pore expansion.…”

Section: Resultsmentioning

confidence: 99%

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Translation of a solution-based biomineralization concept into a carrier-based delivery system via the use of expanded-pore mesoporous silica

et al. 2016

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Mineralization of collagen fibrils using solution-based systems containing biomimetic analogs of matrix proteins to stabilize supersaturated calcium phosphate solutions have been predictably achieved in-vitro. Solution-based systems have limitations when used for in-situ remineralization of human hypomineralized tissues because periodic replenishment of the mineralizing solution is infeasible. A carrier-based platform designed for delivering mineral precursors would be highly desirable. In the present work, mesoporous silica nanoparticles with expanded pores (eMSN; 14.8 nm) were synthesized. Polyacrylic acid-stabilized amorphous calcium phosphate (PA-ACP) was generated from a supersaturated calcium and phosphate ion-containing solution, and chosen as the model mineralizing phase. After amine functionalization (AF) of the eMSN through a post-grafting method, the positively-charged AF-eMSN enabled loading of PA-ACP by electrostatic interaction. In-vitro cytotoxicity testing indicated that PA-ACP@AF-eMSN was highly biocompatible. The release kinetics of mineralization precursors from PA-ACP@AF-eMSN was characterized by an initial period of rapid calcium and phosphate release that reached a plateau after 120 hr. Intrafibrillar mineralization was examined using a 2-D fibrillar collagen model; successful mineralization was confirmed using transmission electron microscopy. To date, this is the first endeavor that employs expanded-pore mesoporous silica to deliver polymer-stabilized intermediate precursors of calcium phosphate for intrafibrillar mineralization of collagen. The carrier-based delivery system bridges the gap between contemporary solution-based biomineralization concepts and clinical practice, and is useful for in-situ remineralization of bone and teeth.

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“…For exact measurement and positioning of atoms in complex structures Rietveld analysis is used. In severe environments such as very high temperature and during chemical reactions XRD can be used [68].…”

Section: Characterization Of Bimetallic Catalystsmentioning

confidence: 99%

Bimetallic Catalysts Containing Gold and Palladium for Environmentally Important Reactions

2016

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Supported bimetallic nanoparticles (SBN) are extensively used as efficient redox catalysts. This kind of catalysis particularly using SBN has attracted immense research interest compared to their parent metals due to their unique physico-chemical properties. The primary objective of this contribution is to provide comprehensive overview about SBN and their application as promising catalysts. The present review contains four sections in total. Section 1 starts with a general introduction, recent progress, and brief summary of the application of SBN as promising catalysts for different applications. Section 2 reviews the preparation and characterization methods of SBN for a wide range of catalytic reactions. Section 3 concentrates on our own results related to the application of SBN in heterogeneous catalysis. In this section, the oxidation of cyclohexane to adipic acid (an eco-friendly and novel approach) will be discussed. In addition, the application of bimetallic Pd catalysts for vapor phase toluene acetoxylation in a fixed bed reactor will also be highlighted. Acetoxylation of toluene to benzyl acetate is another green route to synthesize benzyl acetate in one step. Finally, Section 1 describes the summary of the main points and also presents an outlook on the application of SBN as promising catalysts for the production of valuable products.

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Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers

Cited by 35 publications

References 42 publications

Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

Translation of a solution-based biomineralization concept into a carrier-based delivery system via the use of expanded-pore mesoporous silica

Bimetallic Catalysts Containing Gold and Palladium for Environmentally Important Reactions

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