2013
DOI: 10.1016/j.mattod.2013.06.005
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Abstract: Biomimetic nanofibrous scaffolds mimicking important features of the native extracellular matrix provide a promising strategy to restore functions or achieve favorable responses for tissue regeneration. This review provides a brief overview of current state-of-the-art research designing and using biomimetic electrospun nanofibers as scaffolds for tissue engineering. It begins with a brief introduction of electrospinning and nanofibers, with a focus on issues related to the biomimetic design aspects. The review… Show more

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Cited by 656 publications
(447 citation statements)
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“…All the scaffolds showed random, nonwoven architecture with interconnected pores which mimic the extracellular matrix (ECM) of the native tissues like bone, cartilage and skin. ECM components in tissues like bone, cartilage and skin are in fibrous form and present in nano dimensions (13). Thus fibrous architecture of scaffolds closely mimics the architecture of native tissue ECM.…”
Section: Microstructure Of the Scaffold By Semmentioning
confidence: 99%
“…All the scaffolds showed random, nonwoven architecture with interconnected pores which mimic the extracellular matrix (ECM) of the native tissues like bone, cartilage and skin. ECM components in tissues like bone, cartilage and skin are in fibrous form and present in nano dimensions (13). Thus fibrous architecture of scaffolds closely mimics the architecture of native tissue ECM.…”
Section: Microstructure Of the Scaffold By Semmentioning
confidence: 99%
“…Bone tissue scaffolds require a 3D structure with desirable mechanical properties and great thickness for bone regeneration (27). Electrospun nanofibrous scaffolds are very thin layers (two-dimensional nonwoven) (28,29), which limits their application in bone tissue engineering. But, preparation of multilayered structure with uniform cell distribution can be efficient in bone tissue engineering.…”
Section: Discussionmentioning
confidence: 99%
“…[25] The final material is 2D at a macroscale but 3D at the microscale and provides a structural mimic of the fibrous structural proteins abundant in the ECM. [26] To produce these materials, a high voltage is applied between a collection plate and spinneret (metal needle) from which a polymer solution is slowly dispensed (Figure 3). This method is simple and versatile; it can be used with any materials that can be dispersed in the spinning solution enough to pass through the spinneret.…”
Section: Electrospun Materialsmentioning
confidence: 99%