Biomedical Applications of Nanoceria: New Roles for an Old Player

Kargozar, Saeid; Baino, Francesco; Hoseini, Seyed Javad; Hamzehlou, Sepideh; Darroudi, Majid; Verdi, Javad; Hasanzadeh, Leila; Kim, Hae‐Won; Mozafari, Masoud

doi:10.2217/nnm-2018-0189

Cited by 97 publications

(61 citation statements)

References 129 publications

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“…Although there are studies on NC compatibility in cell and animal models, no data exist about the effects of NC on human hemostatic system. A recent study, performed in mice, showed that intratracheal instillation of NC promoted thrombosis in vivo , probably as consequence of increased oxidative stress and inflammation .…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that NC, acting as ROS scavengers, are able to mimic the activity of SOD and catalase . According to their important intrinsic antioxidant and autoregenerative properties, NC applications have attracted increasingly interest in different fields of medicine . NC have been evaluated in vivo for their efficacy as treatment in a variety of disease states, with applications ranging from reproductive, to gastrointestinal, to ophthalmologic, to neurological and cardiovascular health .…”

Section: Introductionmentioning

confidence: 99%

“…4 According to their important intrinsic antioxidant and autoregenerative properties, NC applications have attracted increasingly interest in different fields of medicine. 5,6 NC have been evaluated in vivo for their efficacy as treatment in a variety of disease states, with applications ranging from reproductive, 7 to gastrointestinal, 8 to ophthalmologic, 9,10 to neurological 11 and cardiovascular health. 12 In anticancer treatment, data have shown NC to be toxic to cancer cells sensitizing them to radiation therapy, while displaying minimal toxicity to normal tissues.…”

Section: Introductionmentioning

confidence: 99%

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Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Turco

Ciofani

Cappello

et al. 2019

J Biomedical Materials Res

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Cerium oxide nanoparticles (nanoceria [NC]) have attracted much attention in biomedicine due to their surface composition that confers interesting redox activities and regenerative properties. Studies have demonstrated that the application of NPs in biomedicine can influence components of hemostatic system, inducing blood clotting, alterations of blood cells, and endothelial cell functions. NC were tested in vitro to assess their hemocompatibility and anticoagulant, anti‐inflammatory, and anti‐senescence activity in human endothelial cells. Hemocompatibility has been evaluated in vitro looking at the impact of NC on coagulation times, fibrinogen, and platelet aggregation. The effect of NC on vascular endothelial cells were assayed by testing cell viability, antioxidant activity, anticoagulant (tissue factor [TF]‐mRNA expression) and anti‐inflammatory properties (VCAM‐1 exposure, cytokine release), and senescence (telomere shortening). NC did not show significant effects on coagulation process, hemolysis, or platelet aggregation. In endothelial cells, NC did not affect cell viability, reduced oxidative stress, inhibited mRNA‐TF expression, VCAM‐1 expression, and cytokine release. Moreover, NC reduce telomere shortening, possibly counteracting premature senescence. The hemocompatibility combined with anticoagulant and anti‐inflammatory phenotype and the ability of counteract the premature senescence in vascular cells make NC a promising therapeutic tool in oxidative stress‐related conditions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Turco

Ciofani

Cappello

et al. 2019

J Biomedical Materials Res

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“…Cerium oxide nanoparticles are synthesized by two kinds of approaches: the chemical methods and the green‐based methods …”

Section: Inorganic Nano‐antioxidants For Biomedical Applicationsmentioning

confidence: 99%

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

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Many central nervous system (CNS) diseases are still incurable and only symptomatic treatments are available. Oxidative stress is suggested to be a common hallmark, being able to cause and exacerbate the neuronal cell dysfunctions at the basis of these pathologies, such as mitochondrial impairments, accumulation of misfolded proteins, cell membrane damages, and apoptosis induction. Several antioxidant compounds are tested as potential countermeasures for CNS disorders, but their efficacy is often hindered by the loss of antioxidant properties due to enzymatic degradation, low bioavailability, poor water solubility, and insufficient blood–brain barrier crossing efficiency. To overcome the limitations of antioxidant molecules, exploitation of nanostructures, either for their delivery or with inherent antioxidant properties, is proposed. In this review, after a brief discussion concerning the role of the blood–brain barrier in the CNS and the involvement of oxidative stress in some neurodegenerative diseases, the most interesting research concerning the use of nano‐antioxidants is introduced and discussed, focusing on the synthesis procedures, functionalization strategies, in vitro and in vivo tests, and on recent clinical trials.

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“…With the emergence of nanotechnology, smaller sizes of metals (1-100 nm) were evaluated by scientists to exactly determine their advantages and disadvantages for living systems, as nano-sized particles exhibit distinct biological effects in comparison to their bulk counterparts [ 3 , 4 ]. Among different types of nano-metals, cerium oxide nanoparticles (CNPs or nanoceria) are considered one of the most promising substances in biomedical engineering approaches [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

Self Cite

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Biomedical Applications of Nanoceria: New Roles for an Old Player

Cited by 97 publications

References 129 publications

Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Effects of cerium oxide nanoparticles on hemostasis: Coagulation, platelets, and vascular endothelial cells

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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