Biomechanical behaviour of oesophageal tissues: Material and structural configuration, experimental data and constitutive analysis

Natali, Arturo N.; Carniel, Emanuele Luigi; Gregersen, Hans

doi:10.1016/j.medengphy.2009.07.003

Cited by 99 publications

(137 citation statements)

References 25 publications

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“…The modeled esophageal wall was composed by mucosal, CM and LM layers. Experiments show that the mucosal layer is composed by collagen fibrils and connective tissue (Natali et al 2009). The CM and LM layers consist of circumferentially and longitudinally oriented muscle fibers, respectively (Gilbert et al 2008).…”

Section: Methodsmentioning

confidence: 99%

“…Most studies of the mucosa relate to changes in its permeability as a defense mechanism against intraluminal acidity (Sarosiek and McCallum 2000; Orlando 2006), and biomechanical studies mainly focused on its geometry and material properties from in-vitro tests (Gregersen et al 2000; Yang et al 2006a,b, 2007; Zhao et al 2007; Natali et al 2009; Stavropoulou et al 2009; Li et al 2011a). The mucosa is generally modeled as an anisotropic elastic material, but presumably due to the complexity of biological tissues and of in-vitro testing, the reported material properties vary substantially among studies (Yang et al 2006a; Zhao et al 2007; Natali et al 2009; Stavropoulou et al 2009). Mucosal folding, which probably originates from residual stress in the esophageal wall, has also attracted substantial interest among researchers (Gregersen et al 2000; Yang et al 2007; Li et al 2011a,b).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simulation studies of the role of esophageal mucosa in bolus transport

Kou¹,

Pandolfino²,

Kahrilas³

et al. 2017

Biomech Model Mechanobiol

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Based on a fully coupled computational model for esophageal transport, we analyzed the role of the mucosa (including the submucosa) in esophageal bolus transport and how bolus transport is affected by mucosal stiffness. Two groups of studies were conducted using a computational model. In the first group, a base case that represents normal esophageal transport and two hypothetical cases were simulated: 1) esophageal mucosa replaced by muscle and 2) esophagus without mucosa. For the base case, the geometric configuration of the esophageal wall was examined and the mechanical role of mucosa was analyzed. For the hypothetical cases, the pressure field and transport features were examined. In the second group of studies, cases with mucosa of varying stiffness were simulated. Overall transport characteristics were examined and both pressure and geometry were analyzed. Results show that a compliant mucosa helped accommodate the incoming bolus and lubricate the moving bolus. Bolus transport was marginally achieved without mucosa or with mucosa replaced by muscle. A stiff mucosa greatly impaired bolus transport due to lowered esophageal distensibility and increased luminal pressure. We conclude that mucosa is essential for normal esophageal transport function. Mechanically stiffened mucosa reduces the distensibility of the esophagus by obstructing luminal opening and bolus transport. Mucosal stiffening may be relevant in diseases characterized by reduced esophageal distensibility, elevated intra-bolus pressure, and/or hypertensive muscle contraction such as eosinophilic esophagitis and jackhammer esophagus.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Simulation studies of the role of esophageal mucosa in bolus transport

Kou¹,

Pandolfino²,

Kahrilas³

et al. 2017

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…After the creep step, the sample was deflated. In total, 16 inflation tests were performed on each experimental sample according to different inflated top pressures, such as 4, 6,8,10,14,18,22,26,30,34,38,46, 54, 62, 70 and 78 mmHg. The pressure range of experimentations, such as 4-78 mmHg, and the pressure rate were identified by preliminary inflation tests that were developed on further colon samples.…”

Section: Experimental Activitymentioning

confidence: 99%

Analysis of the structural behaviour of colonic segments by inflation tests: Experimental activity and physio-mechanical model

Carniel

Mencattelli

Bonsignori

et al. 2015

Proc Inst Mech Eng H

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A coupled experimental and computational approach is provided for the identification of the structural behaviour of gastrointestinal regions, accounting for both elastic and visco-elastic properties. The developed procedure is applied to characterize the mechanics of gastrointestinal samples from pig colons. Experimental data about the structural behaviour of colonic segments are provided by inflation tests. Different inflation processes are performed according to progressively increasing top pressure conditions. Each inflation test consists of an air in-flow, according to an almost constant increasing pressure rate, such as 3.5 mmHg/s, up to a prescribed top pressure, which is held constant for about 300 s to allow the development of creep phenomena. Different tests are interspersed by 600 s of rest to allow the recovery of the tissues' mechanical condition. Data from structural tests are post-processed by a physio-mechanical model in order to identify the mechanical parameters that interpret both the non-linear elastic behaviour of the sample, as the instantaneous pressure-stretch trend, and the time-dependent response, as the stretch increase during the creep processes. The parameters are identified by minimizing the discrepancy between experimental and model results. Different sets of parameters are evaluated for different specimens from different pigs. A statistical analysis is performed to evaluate the distribution of the parameters and to assess the reliability of the experimental and computational activities.

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“…Dans sa partie proximale la composition en fibres musculaires lisses est faible (3.9 et 6.1% pour les couches circulaires et longitudinales respectivement) en opposition à la partie distale (62.7% et 54.4%). Le tiers moyen correspond à une zone de transition (33% et 40%) [27].…”

Section: Méthodesunclassified

Esophageal tissue engineering

Luc

Durand

Collet

et al. 2014

Expert Review of Medical Devices

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Decellularized matrixes (DM) are commonly used to facilitate a constructive remodeling response in several types of tissue, including the esophagus. Surgical procedure of the esophagus is often complicated by stricture, but preclinical studies have shown that the use of a DM can mitigate stricture and promote a constructive outcome.Recognizing the potential benefits of DM derived from homologous tissue (i.e., site-specific ECM), the objective of the present study was to prepare, characterize, and assess the in-vivo remodeling properties of DM from porcine esophagus.The developed protocol for esophageal DM preparation is compliant with previously established criteria of decellularization and results in a scaffold that maintains important biologic components and an ultrastructure consistent with a good mechanical behavior. Stem cells remained viable when seeded upon the esophageal DM in vitro, and the in-vivo host response showed a pattern of constructive remodeling when implanted in soft tissue.

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Biomechanical behaviour of oesophageal tissues: Material and structural configuration, experimental data and constitutive analysis

Cited by 99 publications

References 25 publications

Simulation studies of the role of esophageal mucosa in bolus transport

Simulation studies of the role of esophageal mucosa in bolus transport

Analysis of the structural behaviour of colonic segments by inflation tests: Experimental activity and physio-mechanical model

Esophageal tissue engineering

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