Biomaterials for articular cartilage tissue engineering: Learning from biology

Armiento, Angela R.; Stoddart, Martin J.; Alini, Mauro; Eglin, David

doi:10.1016/j.actbio.2017.11.021

Cited by 464 publications

(359 citation statements)

References 300 publications

Supporting

Mentioning

326

Contrasting

Unclassified

Order By: Relevance

“…The literature in this field states that the Young's modulus of cartilage lies in the range of 0.1 to 2.1 MPa depending on the location. Much of the cartilage mimicking materials in the literature are able to closely replicate or encompass this range within the material property range . Although most of this comparative literature refers to the compressive modulus of either cartilage or the cartilage mimicking material is it difficult to comment on the compressive properties of our SAP:GAG gels as we only studied the shear properties of our gels.…”

Section: Rheologymentioning

confidence: 99%

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

Barco

Ingham

Fisher

et al. 2018

Journal of Peptide Science

View full text Add to dashboard Cite

Peptide-based hydrogels are of interest for their potential use in regenerative medicine. Combining these hydrogels with materials that may enhance their physical and biological properties, such as glycosaminoglycans, has the potential to extend their range of biomedical applications, for example in the repair of early cartilage degeneration. The aim of this study was to combine three self-assembling peptides (P -4, P -8, and P -12) with chondroitin sulphate at two molar ratios of 1:16 and 1:64 in 130 and 230 mM Na salt concentrations. The study investigates the effects of mixing self-assembling peptide and glycosaminoglycan on the physical and mechanical properties at 37°C. Peptide alone, chondroitin sulphate alone, and peptide in combination with chondroitin sulphate were analysed using Fourier transform infrared spectroscopy to determine the β-sheet percentage, transmission electron microscopy to determine the fibril morphology, and rheology to determine the elastic and viscous modulus of the materials. All of the variables (peptide, salt concentration, and chondroitin sulphate molar ratio) had an effect on the mechanical properties, β-sheet formation, and fibril morphology of the hydrogels. P -4 and P -8-chondroitin sulphate mixtures, at both molar ratios, were shown to have a high β-sheet percentage, dense entangled fibrillar networks, as well as high mechanical stiffness in both (130 and 230 mM) Na salt solutions when compared with the P -12/chondroitin sulphate mixtures. These peptide/chondroitin sulphate hydrogels show promise for biomedical applications in glycosaminoglycan depleted tissues.

show abstract

Section: Rheologymentioning

confidence: 99%

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

Barco

Ingham

Fisher

et al. 2018

Journal of Peptide Science

View full text Add to dashboard Cite

show abstract

“…Articular cartilage is a highly specialized tissue populated by chondrocyte cells that are embedded in an interpenetrated network of collagen fibers (mainly type II) and glycosaminoglycans (GAGs; Armiento, Stoddart, Alini, & Eglin, ; Bernhard & Vunjak‐Novakovic, ). This tissue displays peculiar viscoelastic features and it acts together with the subchondral bone to adsorb and distribute mechanical loads at synovial joints (Pan et al, ).…”

Section: Introductionmentioning

confidence: 99%

Development of biodegradable membranes for the delivery of a bioactive chitosan‐derivative on cartilage defects: A preliminary investigation

Scognamiglio

Travan

Borgogna

et al. 2020

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Choi et al, 2018; Magnusson & Kjaer, 2019). In materials science, this collagen structural framework is commonly referred to as the “fibre phase” of a material, surrounded by the primarily non-collagenous and glycoprotein-rich components of the ECM, termed the “matrix phase”(Armiento et al, 2018; C. T. Thorpe & Screen, 2016).…”

Section: Introductionmentioning

confidence: 99%

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

Zamboulis

Thorpe

Kharaz

et al. 2020

Preprint

View full text Add to dashboard Cite

Mature connective tissues demonstrate highly specialised properties, remarkably adapted to meet their functional requirements. Tissue adaptation to environmental cues can occur throughout life and poor adaptation commonly results in injury. However, the temporal nature and drivers of functional adaptation remain undefined. Here, we explore functional adaptation and specialisation of mechanically loaded tissues using tendon; a simple aligned biological composite, in which the collagen (fibre phase) and surrounding predominantly non-collagenous matrix (matrix phase) can be interrogated independently. Using an equine model of late development, we report the first phase-specific analysis of biomechanical, structural and compositional changes seen in functional adaptation, demonstrating adaptation occurs postnatally, following mechanical loading, and is almost exclusively localised to the non-collagenous matrix phase. These novel data redefine adaptation in connective tissue, highlighting the fundamental importance of non-collagenous matrix and suggesting that regenerative medicine strategies should change focus from the fibrous to the non-collagenous matrix phase of tissue.

show abstract

Biomaterials for articular cartilage tissue engineering: Learning from biology

Cited by 464 publications

References 300 publications

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

On the design and efficacy assessment of self‐assembling peptide‐based hydrogel‐glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

Development of biodegradable membranes for the delivery of a bioactive chitosan‐derivative on cartilage defects: A preliminary investigation

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

Contact Info

Product

Resources

About