Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data

Steckling, Nadine; Gotti, Alberto; Blüml, Stephan; Chapizanis, Dimitris; Costopoulou, Danae; Vocht, Frank de; Garí, Mercè; Grimalt, Joan O.; Heath, Ester; Hiscock, Rosemary; Jagodic, Marta; Karakitsios, Spyros; Kedikoglou, Kleopatra; Kosjek, Tina; Leondiadis, Leondios; Maggos, Thomas; Mazej, Darja; Polańska, Kinga; Povey, Andrew C.; Rovira, Joaquim; Schoierer, Julia; Schuhmacher, Marta; Špirić, Zdravko; Stajnko, Anja; Stierum, Rob; Tratnik, Janja Snoj; Vassiliadou, Irene; Annesi‐Maesano, Isabella; Horvat, Milena; Sarigiannis, D

doi:10.1016/j.envres.2018.02.041

Cited by 66 publications

(45 citation statements)

References 83 publications

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“…Given the challenges of exposure measurement, movement toward biomarkers of risk that can act as a readout of the effect of environmental exposures may ultimately be the answer . Examples of such markers include pesticide‐induced gene mutations and biological markers of oxidative stress .…”

Section: The Next 10 Yearsmentioning

confidence: 99%

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

2019

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There is evidence from observational studies for a role of a number of environmental exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental and lifestyle associations, if causal, represent opportunities for Parkinson's disease prevention or disease modification at individual and population levels. In the past decade, additional evidence has been published that improves causal inference and/or enhances our understanding of the complexity of these associations. A number of gene–environment interactions have been elucidated, and our understanding of the roles of physical activity, pesticide and other chemical exposures, dietary habits, emotional stress, head injury, and smoking has been refined. In the next decade, better techniques will help us to close the gaps in our knowledge, including taking into account Parkinson's disease heterogeneity and gene and risk factor interactions in observational studies. To do this, larger datasets, global consortia, genomewide environment interaction studies, prospective studies throughout the lifespan, and improvements in the methodology of clinical trials of physical activity will be key. Despite the caveats of observational studies, a number of low‐risk and potentially high‐yield recommendations for lifestyle modification could be made to minimize the individual and societal burdens of Parkinson's disease, including dietary modifications, increasing physical activity, and head injury avoidance. Furthermore, a reduction in pesticide use could have a major impact on global health related to and beyond Parkinson's disease. Given the increasing prevalence of this disorder, formulating and promoting these recommendations should be a high priority. © 2019 International Parkinson and Movement Disorder Society

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Section: The Next 10 Yearsmentioning

confidence: 99%

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

2019

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“…One approach has been to apply metabolomics on consecutive saliva samples, assessing the 'saliva exposome', as it is easy to collect and measure, and can be used to monitor individual health trajectories (115). Biomarkers of exposure also enable exposome-wide association studies (EWAS) 9 (116,117), which have promise in the near future. Why?…”

Section: Exposomicsmentioning

confidence: 99%

Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases

Litman

2019

APMIS

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“…The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts. To understand the complexity of exposures faced throughout the life span, both traditional and nontraditional biomonitoring methods should be used . Exposomic approaches differ from traditional biomonitoring methods in that they can include all exposures of potential health significance, whether from endogenous or exogenous sources.…”

Section: Framing the Issuementioning

confidence: 99%

Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document

Agache

Miller

Gern

et al. 2018

Allergy

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Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to allergic diseases and asthma. Under the PRAC- TALL collaboration between the European Academy of Allergy and ClinicalImmunology (EAACI) and the American Academy of Allergy, Asthma, and Immunology (AAAAI), we evaluated the current concepts and the unmet needs on the role of the exposome in allergic diseases and asthma.

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Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data

Cited by 66 publications

References 83 publications

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

Environment, lifestyle, and Parkinson's disease: Implications for prevention in the next decade

Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases

Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document

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