Biomarkers of antioxidant status and lipid peroxidation in elderly patients with hypertension

Pawluk, Hanna; Pawluk, Robert; Robaczewska, Joanna; Kędziora–Kornatowska, Kornelia; Kędziora, J

doi:10.1080/13510002.2017.1372072

Cited by 28 publications

(21 citation statements)

References 23 publications

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“…Nonetheless, after reviewing the treatment used for DM patients, we found that most of them include anti-oxidants 17 . Also, it is known that certain drugs used for the treatment of HA interact with the antioxidant enzymes like superoxide dismutase (SOD) and catalases (CAT); patients with no HA treatment have a reduced activity of these enzymes, while patients receiving treatment for hypertension show an increased activity of both 13 .…”

Section: Discussionmentioning

confidence: 99%

“…An increase in ROS production and lipid peroxidation has been reported in patients with DM, where chronic damage by OS is associated to occurrence and complications of the disease 12 . Moreover, in patients with HT it is known that OS alters the function of the endothelium and has a direct effect on the vascular contraction, due to the reduction of NO 13 . The increase in OS generates other alterations in the regulatory system that affect hypertension, including the positive regulation of the renin-angiotensin-aldosterone system, the activation of the sympathetic nervous system, the disturbances of the cellular signalling of the G-protein, inflammation, and alteration of T-cells function 13 .…”

Section: Introductionmentioning

confidence: 99%

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Hypertension and diabetes mellitus association to oxidative stress in an elderly population

Rodríguez-Castañeda

Martinez-Gonzales

Sánchez-Arenas³

et al. 2018

Preprint

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Background: Mexico City has the highest aging rate in the country, as well as a high prevalence of diabetes mellitus (DM) and arterial hypertension (HT). All three on their own, are known to increase oxidative stress (OE).Methods: Final groups included 18 patients without DM or HT (control group), 12 with DM, 23 with HT, and 18 with DM and HT. The EO was measured by the quantification of reactive oxygen species (ROS), and by determination of lipid peroxidation.Results: HAS patients showed increased ROS levels as did men with HAS compared with the respective DM and HT groups. Also, women of the control group showed higher levels of ROS compared with men. HT in an aged population turned out to be the most influential factor for oxidative stress increase while DM had no effect whatsoever.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypertension and diabetes mellitus association to oxidative stress in an elderly population

Rodríguez-Castañeda

Martinez-Gonzales

Sánchez-Arenas³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…It is known that hypertension is associated with an increased degree of lipid peroxidation [20], so we measured the levels of one of the products of lipid peroxidation, malondialdehyde (MDA), in rat serum. The levels of MDA products in the serum were used as an indicator for the degree of lipid peroxidation ( Figure 2D).…”

Section: Single Oral Dose Of P-spi Improves Serum Parameters Associatmentioning

confidence: 99%

Influence of fermented soy protein consumption on hypertension and gut microbial modulation in spontaneous hypertensive rats

Daliri

Ofosu

Chelliah

et al. 2020

Bioscience of Microbiota, Food and Health

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Plant proteins are known to possess important bioactive peptides and have a positive impact on gut microbial modulation. In this study, we studied the ability of a single dose of a fermented soy protein product (P-SPI) to reduce high blood pressure in spontaneous hypertensive rats (SHR) and how it modulates the gut microbiota after six weeks of feeding. SHRs were fed with P-SPI, Captopril or distilled water once, and their blood pressures were monitored from the first to twelfth-hour post-administration. Consumption of P-SPI significantly reduced systolic and diastolic blood pressures up to the sixth hour by 25 ± 4 mmHg and 40 ± 5 mmHg respectively. P-SPI consumption inhibited serum ACE activity, increased superoxide dismutase activity and nitric oxide levels and reduced malondialdehyde levels in serum. Analysis of fecal microbial 16S rRNA of hypertensive rats revealed a significant reduction in microbial richness and diversity in the gut, while P-SPI consumption improved microbial richness and increased diversity. Also, P-SPI feeding significantly reduced the Firmicutes/Bacteroidetes ratio, increased propionate-and H 2 S-producing bacteria and reduced Streptococcaceae and Erysipelotrichales levels. Our results show that P-SPI is a potential antihypertensive functional food which could remodel the altered gut microbiota of hypertensive patients.

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“…Îñîáëèâó óâàãó ïðèä³ëÿºòüñÿ âèâ÷åííþ åíäîòåë³éíî¿ äèñôóíêö³¿ ïðè àðòåð³éí³é ã³ïåðòåíç³¿. Ñåðåä âàaeëèâèõ ÷èííèê³â ðåãó-ëÿö³¿ àðòåð³éíîãî òèñêó âèä³ëÿþòü L-àðã³í³í, îêñèä àçîòó [19 ], ñ³ðêîâîäåíü [21].…”

Section: âñòóïunclassified

“…Òàê, â³äì³÷àâñÿ ñèëüíèé êîðåëÿòèâíèé âçàºìîçâ'ÿçîê ì³ae L-àðã³í³íîì òà NO, à òàêîae íå´àòèâíèé çâ'ÿçîê ñåðåäíüî¿ ñèëè ì³ae L-àð-ã³í³íîì òà í³òðàòàìè ÿê äî, òàê ³ ï³ñëÿ ô³çè÷íîãî íàâàíòàaeåííÿ. Â³äîìî, ùî L-àðã³í³í âèñòóïàº ñóáñòðàòîì äëÿ ïðîäóêö³¿ NO, à í³òðàòè º ïðîäóêòîì ìåòàáîë³çìó í³òðî´åí îêñèäó [19].…”

Section: ðåçóëüòàòè é îáãîâîðåííÿunclassified

The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension

Dronyk

Yavorsky

Sklyarov

et al. 2019

AML

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Ëüâ³âñüêèé íàö³îíàëüíèé ìåäè÷íèé óí³âåðñèòåò ³ìåí³ Äàíèëà Ãàëèöüêîãî 1 Êàôåäðà ïðîïåäåâòèêè âíóòð³øíüî¿ ìåäèöèíè ¹2 (çàâ.-ïðîô. Äóäêà Ð.ß.) 2 Êàôåäðà á³îõ³ì³¿ (çàâ.-ïðîô. Ñêëÿðîâ Î.ß.) 3 Êàôåäðà íåâðîëî´³¿ (çàâ. ïðîô. Íåãðè÷ Ò.².) Ðåôåðàò Ìåòà. Âèçíà÷èòè í³òðîçî-îêñèäàòèâíèé ñòàí, âì³ñò ñ³ðêîâîäíþ òà êîðòèçîëó â ñèðîâàòö³ êðîâ³ ó îñ³á ç àðòåð³éíîþ ã³ïåðòåíç³ºþ ²² ñòàä³¿ çà óìîâ ô³çè÷íîãî íàâàíòàaeåííÿ. Ìàòåð³àë ³ ìåòîäè. Îáñòåaeåíî 30 îñ³á ç àðòåð³éíîþ ã³ïåðòåíç³ºþ ²² ñòàä³¿. Îáñòåaeóâàí³ îñîáè âèêîíóâàëè íà âåëîåðãîìåòð³ äâîñòóïåíåâå ô³çè÷íå íàâàíòàaeåííÿ ç ³íòåíñèâí³ñòþ, ÿêà â³äïîâ³äàëà 50 ³ 75 % íàëåaeíîãî ìàêñèìàëüíîãî ñïîaeèâàííÿ êèñíþ îð´à-í³çìîì. Ðåçóëüòàòè é îáãîâîðåííÿ. Ó ñèðîâàòö³ êðîâ³ ïàö³-ºíò³â äî òà ï³ñëÿ ô³çè÷íîãî íàâàíòàaeåííÿ âèçíà÷àëè âì³ñò ÒÁÊ-àêòèâíèõ ïðîäóêò³â, ñ³ðêîâîäíþ, L-àðã³-í³íó, í³òðèò-àí³îíó, ñóìó í³òðèò³â òà í³òðàò³â, êîðòèçîëó, àêòèâí³ñòü ÑÎÄ, êàòàëàçè, àðã³íàçè. Â³äì³-÷åíî â³ðîã³äíå çá³ëüøåííÿ L-àðã³í³íó òà ñ³ðêîâîäíþ íà òë³ çìåíøåííÿ âì³ñòó í³òðèò-àí³îíó. Âèñëîâëåíî ïðèïóùåííÿ, ùî â îñ³á ç ã³ïåðòîí³÷íîþ õâîðîáîþ çà âïëèâó ô³çè÷íîãî íàâàíòàaeåííÿ çíèaeóºòüñÿ ñèíòåç NO, à âàçîäèëàòàö³ÿ òà âàçîïðîòåêö³ÿ çä³éñíþþòüñÿ çà ðàõóíîê ï³äâèùåííÿ ð³âíÿ ñ³ðêîâîäíþ. Âèñíîâêè. Ï³äâèùåííÿ ð³âíÿ L-àðã³í³íó ³ ñ³ðêîâîäíþ òà çíèaeåííÿ ð³âíÿ í³òðèò-àí³îíó ìîaeíà ââàaeàòè ìàðêåðàìè îö³íêè íåãàéíèõ çì³í ó ïàö³ºíò³â ç àðòå-ð³éíîþ ã³ïåðòåíç³ºþ ï³ñëÿ ô³çè÷íîãî íàâàíòàaeåííÿ. Øâèäê³ñòü ðåàãóâàííÿ ôåðìåíòíèõ ñèñòåì ó â³äïî-â³äü íà ô³çè÷íå íàâàíòàaeåííÿ ó ïàö³ºíò³â ïðè ï³ä-âèùåíí³ àðòåð³éíîãî òèñêó º ð³çíîþ.

show abstract

Biomarkers of antioxidant status and lipid peroxidation in elderly patients with hypertension

Cited by 28 publications

References 23 publications

Hypertension and diabetes mellitus association to oxidative stress in an elderly population

Hypertension and diabetes mellitus association to oxidative stress in an elderly population

Influence of fermented soy protein consumption on hypertension and gut microbial modulation in spontaneous hypertensive rats

The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension

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