Biomarkers as a tool to assess effects of chromium (VI): Comparison of responses in zebrafish early life stages and adults

Domingues, Inês; Oliveira, Rhaul; Lourenço, Joana; Grisólia, César Koppe; Mendo, Sónia; Soares, Amadeu M.V.M.

doi:10.1016/j.cbpc.2010.05.010

Cited by 137 publications

(78 citation statements)

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“…In contrast, sodium benzoate increases axon projections (Tsay et al, 2007). Some chemicals, such as sodium benzoate and triclosan, increase signal substances in neuronal synapses, whereas others such as chlorpyrifos-oxon (CPO) and chromium decrease or inhibit it (Tsay et al, 2007;Oliveira et al, 2009;Domingues et al, 2010;Jacobson et al, 2010) (Table 7). Altered synapse function is likely to have neuronal developmental effects that might not be obvious until later in life (Kaindl and Ikonomidou, 2007;Neal and Guilarte, 2010).…”

Section: Neuronal Developmental Toxicitymentioning

confidence: 93%

Developmental toxicity screening in zebrafish

McCollum

Ducharme

Bondesson

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

133

101

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Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for medium- and high-throughput assessments, which may help to accelerate the restructuring of standards. Zebrafish have high developmental similarity to mammals in most aspects of embryo development, including early embryonic processes, and on cardiovascular, somite, muscular, skeletal, and neuronal systems. Here, we briefly describe the development of these systems and then chronicle the toxic impacts assessed following chemical exposure. We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies.

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Section: Neuronal Developmental Toxicitymentioning

confidence: 93%

Developmental toxicity screening in zebrafish

McCollum

Ducharme

Bondesson

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

133

101

View full text Add to dashboard Cite

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“…Feeding inhibition of D. magna has been used as a sensitive indicator of toxicity and is an ecologically relevant endpoint since food intake determines energy acquisition and further allocation and, thus, growth, reproduction and survival of individuals (Nogueira et al 2004). Moreover, the early stress responses caused by ChD on zebrafish embryos were assessed based on a battery of enzymatic biomarkers from different metabolic pathways Domingues et al (2010). Since ChD affects the nervous system of several organisms (Röed 1973;Henschen and Olson 1984;Shaihutdinova et al 2009) the cholinesterase (ChE) was selected due to its key role in the hydrolysis of acetylcholine in peripheral and central nervous systems (Holth et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Lethal and sub lethal effects of the biocide chlorhexidine on aquatic organisms

et al. 2013

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Chlorhexidine is among the most used biocides in Europe, however its toxicity to aquatic organisms is scarcely known. The main objective of this study was to assess the lethal and sub lethal effects of chlorhexidine digluconate (ChD) on four aquatic model organisms: the bacteria Vibrio fischeri, the algae Pseudokirchneriella subcapitata, the crustacean Daphnia magna and the embryos of the fish Danio rerio. ChD was very toxic to algae and crustaceans, with a 72 h-EC50 of 62.2 μg/l and a 48 h-EC50 of 45.0 μg/l, respectively. Toxicity to fish embryos and the bacteria was lower, with a 96 h-EC50 of 804.0 μg/l and a 15 min-EC50 of 1,694.0 μg/l, respectively. Concerning sub lethal effects on D. magna (feeding inhibition) a 6 h-EC50 of 503.7 μg/l was obtained. In fish, ChD caused developmental abnormalities, namely alterations in the amniotic fluid (48 h-EC20 of 753.6 μg/l) and early hatching. Moreover, enzymatic biomarkers on fish embryos showed an induction of cholinesterase activity in all ChD tested concentrations (80-900 μg/l). The catalase activity was also induced at the highest concentration tested (900 μg/l) whereas no changes were observed for glutathione-S-transferase and lactate dehydrogenase activities. The toxicity of ChD to the algae and crustacean raises concerns about its potential effects in aquatic food webs, since these organisms are in the base of trophic chains, and highlights the need for further studies on ChD toxicity to aquatic organisms.

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“…Os efeitos em níveis hierárquicos superiores, como em populações, são sempre precedidos por mudanças nos processos biológicos, que podem ser sinalizadas pelos biomarcadores. As alterações detectadas indicam que os xenobióticos foram absorvidos e distribuídos entre os tecidos e provocaram um efeito tóxico no organismo ( VAN DER OOST et al, 2003), e a elevada sensibilidade das respostas permite identificar o potencial de perigo dos xenobióticos, entender o modo de ação e prevenir os riscos (DOMINGUES et al, 2010).…”

Section: Biomarcadores Bioquímicosunclassified

“…Vários biomarcadores bioquímicos são empregados em avaliações toxicológicas, com destaque para as alterações no sistema colinérgico (DOMINGUES et al, 2010;ANDRADES et al, 2015), no sistema de detoxificação ( VAN DER OOST et al, 2003;GUILHERMINO, 2009;ZHANG et al, 2012, GRAVATO et al, 2014KAUR, 2015) e no balanço energético (MCKEE; KNOWLES, 1986;JANSSEN, 1997;SMOLDERS et al, 2003;SMOLDERS et al, 2004;PATRICIO-SILVA;AMORIM, 2016).…”

Section: Biomarcadores Bioquímicosunclassified

“…Alguns estudos evidenciaram que as alterações em biomarcadores bioquímicos ocorrem em concentrações abaixo daquelas capazes de alterar o desenvolvimento embrionário de zebrafish (DOMINGUES et al, 2010;VAN BOXTEL et al, 2010;ZHANG et al, 2012;PÉREZ et al, 2013;OLIVEIRA et al, 2013;ANDRADE et al, 2015). Portanto, técnicas complementares ao FET, tais como os biomarcadores bioquímicos, aumentam a predição dos resultados ao detectar efeitos mais sensíveis, e fornecem informações adicionais sobre o modo de ação dos tóxicos.…”

Section: Biomarcadores Bioquímicosunclassified

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Avaliação ecogenotoxicológica de corante natural extraído de micro-organismo

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Biomarkers as a tool to assess effects of chromium (VI): Comparison of responses in zebrafish early life stages and adults

Cited by 137 publications

References 50 publications

Developmental toxicity screening in zebrafish

Developmental toxicity screening in zebrafish

Lethal and sub lethal effects of the biocide chlorhexidine on aquatic organisms

Avaliação ecogenotoxicológica de corante natural extraído de micro-organismo

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