Biomarker diversity in increased inflammation: Secondary hemophagocytic syndrome vs. systemic inflammatory response syndrome

Abstract

Introduction: Secondary hemophagocytic syndrome (HPS) and systemic inflammatory response syndrome (SIRS) share similar clinical findings as a result of hyperinflammation. Due to high mortality rates in HPS; it is critical to diagnose promptly.Thus, this study aimed to evaluate the diagnostic and prognostic significance of inflammatory markers in these two increased inflammatory states. Methods:We conducted a prospective observational study including patients hospitalized in the intensive care unit of the

Acute myeloid leukaemia (AML) with KMT2A rearrangement presented with haemophagocytic lymphohistiocytosis (HLH)

“…This case highlighted the importance of rapid diagnosis and risk stratification of driver disease of HLH to enable timely initiation of definitive treatment 1 …”