Current Opinion in Hematology volume 19, issue 4, P299-304 2012 DOI: 10.1097/moh.0b013e328353bbbd View full text
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R. Coleman Lindsley, Ann S. LaCasce

Abstract: Purpose of review Mature B cell lymphomas bearing concurrent chromosomal rearrangement of MYC/8q24 and BCL2/18q21 are associated with an aggressive clinical course and resistance to conventional chemotherapy. This review summarizes the recent literature regarding the clinical and pathologic features of Double-hit lymphomas and outlines current questions about the most accurate and inclusive definition of the disease. Recent findings Comprehensive evaluation of large series of aggressive mature B cell neopl…

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