Infectious Disease Clinics of North America volume 25, issue 4, P895-910 2011 DOI: 10.1016/j.idc.2011.08.002 View full text
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Robert S. Wallis

Abstract: In the decade since tumor necrosis factor α (TNF-α) antagonists were first approved for clinical use, they have proven invaluable for the treatment of specific types of chronic inflammation. Currently licensed TNF blockers fall into two classes, monoclonal antibody (or antibody fragments) and soluble receptor. Although they are equally effective in rheumatoid arthritis and psoriasis, important differences have emerged with regard to efficacy in granulomatous inflammation and risks of granulomatous infections, …

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