Biological properties of hydroxyapatite coatings on titanium dioxide nanotube surfaces using negative pressure method

Wang, Yan; Tang, Shuang; Ding, Ning; Zhang, Zutai

doi:10.1002/jbm.b.35240

Cited by 3 publications

(2 citation statements)

References 36 publications

(65 reference statements)

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“…The interaction between titanium and hydroxyapatite has been studied in the following works [28,29]. According to the results of these studies, titanium oxidizes due to its interaction with oxygen in HA.…”

Section: Sintering Of Titanium and Hydroxyapatite Powdersmentioning

confidence: 99%

Mechanical Grinding of Hydroxyapatite and Its Interaction with Titanium

Mamaeva,

Kenzhegulov,

Panichkin

et al. 2024

Coatings

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The development of promising biocompatible composites based on hydroxyapatite with a metallic component is of great interest to researchers. This article describes the synthesis of hydroxyapatite powder by the hydrolytic method and presents the results of mechanical grinding of hydroxyapatite powder. Additionally, in order to study the interaction between titanium and hydroxyapatite powders, the results of their thermal treatment in the temperature range of 600–900 °C are presented. As a result of the hydrolytic method, a powder consisting of Ca5(PO4)3(OH) and CaO phases with a fraction of 400–600 μm was obtained. According to the results of mechanical grinding, it was determined that with an increase in grinding time from 30 to 120 min, the intensive main diffraction lines corresponding to hydroxyapatite decrease. During the thermal treatment of titanium and hydroxyapatite powders, titanium oxidizes forming suboxides and titanium dioxide (TiO2). At higher temperatures, the hydroxyapatite phase disappears from the mixture, and titanium oxide, calcium phosphate compound, and small amounts of calcium titanate and titanium hydrophosphate are present.

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Section: Sintering Of Titanium and Hydroxyapatite Powdersmentioning

confidence: 99%

Mechanical Grinding of Hydroxyapatite and Its Interaction with Titanium

Mamaeva,

Kenzhegulov,

Panichkin

et al. 2024

Coatings

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“…However, loading HAP into a TiNT structure is a complex and multi-stage process requiring all stages' control and compliance. For example, in the work of X. Shen et al [27,28], the loading process of hydroxyapatite involved a multi-stage process, including soaking and washing the samples. Several methods for loading hydroxyapatite use combined methods [29], such as UV treatment of organic precursors of calcium and phosphorus with their decomposition and formation of HAP.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Titanium Oxide Nanotubes Loaded with Hydroxyapatite

Nahum,

Lugovskoy,

Lugovskoy

et al. 2023

Nanomaterials

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A simple method of synthesis of TiO2 nanotubes (TiNT) loaded with hydroxyapatite (HAP) is described. Such nanotubes find wide applications in various fields, including biomedicine, solar cells, and drug delivery, due to their bioactivity and potential for osseointegration. The Cp-Ti substrate was anodized at a constant voltage of 40 V, with the subsequent heat treatment at 450 °C. The resulting TiNT had a diameter of 100.3 ± 2.8 nm and a length of 3.5 ± 0.04 μm. The best result of the growth rate of HAP in Hanks’ balanced salt solution (Hanks’ BSS) was obtained in calcium glycerophosphate (CG = 0.1 g/L) when precipitates formed on the bottom and walls of the nanotubes. Structural properties, surface wettability, corrosion resistance, and growth rate of HAP as an indicator of the bioactivity of the coating have been studied. X-ray diffraction (XRD), scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), potentiodynamic polarization test (PPC), electrochemical impedance spectroscopy (EIS), and contact angle (CA) measurements were used to characterize HAP-loaded nanotubes (HAP-TiNT). The CA, also serving as an indirect indicator of bioactivity, was 30.4 ± 1.1° for the TiNT not containing HAP. The contact angle value for HAP-TiNT produced in 0.1 g/L CG was 18.2 ± 1.2°, and for HAP-TiNT exposed to Hanks’ BSS for 7 days, the CA was 7.2 ± 0.5°. The corrosion studies and measurement of HAP growth rates after a 7-day exposure to Hanks’ BSS confirmed the result that TiNT processed in 0.1 g/L of CG exhibited the most significant capacity for HAP formation compared to the other tested samples.

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