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“…Previous studies showed that some Phellinus species such as P . linteus [ 21 , 25 , 26 ] and P . baumii [ 23 ] exert their anti-inflammatory effects through inhibiting the expression of nuclear factor-κB (NFκB) p65 and mitogen-activated protein kinases (MAPKs) (e.g., extracellular signal-regulated protein kinase (ERK) and p38).…”
Section: Discussionmentioning
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“…Previous studies showed that some Phellinus species such as P . linteus [ 21 , 25 , 26 ] and P . baumii [ 23 ] exert their anti-inflammatory effects through inhibiting the expression of nuclear factor-κB (NFκB) p65 and mitogen-activated protein kinases (MAPKs) (e.g., extracellular signal-regulated protein kinase (ERK) and p38).…”
Section: Discussionmentioning
“…Adverse effects associated with non-steroidal anti-inflammatory drugs (NSAIDs) arouse the need to develop safe alternatives for the treatment of chronic inflammations ( Sostres et al, 2010 ). Hispolon induces potent anti-inflammatory response by suppressing TNF-α (tumor necrosis factor-α) ( Lin et al, 2014 ), and decreasing MMP-9 via inhibition of NF-κB pathway ( Sun et al, 2015 ). Anti-inflammatory actions of hispolon occur via inhibition of JNK phosphorylation ( Yang et al, 2014 ).…”
Section: Biological Activities Of Hispolonmentioning
“…Phellinus linteus has been found to produce several biologically active compounds that are usually associated with cell walls. These compounds have been suggested to contribute to the enhancement of immunity [6] and tumourretarding effect, antioxidant [7][8][9], anti-inflammatory [10] and antimicrobial activities, [11] and good therapeutic effects on diabetes and obesity [12].…”
Section: Introductionmentioning