Biological Effects of Chemical Pollution in Feral Fish and Shellfish Populations from Ebro River: From Molecular to Individual Level Responses

Piña, Benjamı́n; Raldúa, Demetrio; Barata, Carlos; Faria, Melissa; Navarro, Anna; Damásio, Joana; Olivares, Alba; Quirós, Laia; Pelayo, Sergi; Casado, Marta

doi:10.1007/698_2010_78

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“…Given the wide evolutionary gap between D. polymorpha and vertebrates or D. melanogaster and C. elegans , the existence of common co-expression patterns indicates that the correlation analyses were able to define deeply rooted regulatory networks among Metazoans. GST, SOD, and CAT are part of the cellular defence mechanism against oxidative stress, although they act at very different levels [ 25 , 26 ]. Similarly, HSP90 and HSP70 share the heat-shock responsive element (also found in some metallothionein genes, [ 27 , 25 ]), so its co-expression may well be mediated by this particular regulatory network.…”

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confidence: 99%

qRT-PCR evaluation of the transcriptional response of zebra mussel to heavy metals

et al. 2015

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BackgroundThe transcriptional response of adult zebra mussels (Dreissena polymorpha) to heavy metals (mercury, copper, and cadmium) was analyzed by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) to study the coordinated regulation of different metal-, oxidative stress- and xenobiotic defence-related genes in gills and digestive gland. Regulatory network analyses allowed the comparison of this response between different species and taxa.ResultsChemometric analyses allowed identifying the effects of these metals clearly separating control and treated samples of both tissues. Interactions between the different genes, either in the same or between both tissues, were analysed to identify correlations and to propose stress-related genes’ regulatory networks. These networks were finally compared with existing data from human, mouse, zebrafish, Drosophila and the roundworm to evaluate their mechanistically-known response to metals (and to stressors in general) with the correlations observed in the still poorly-known, invasive zebra mussel.ConclusionsOur analyses found a general conservation of regulation genes and of their interactions among the different considered species, and may serve as a guide to extrapolate regulatory data from model species to lesser-known environmentally (or medically) relevant species.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-015-1567-4) contains supplementary material, which is available to authorized users.

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