Biological characteristics of lactosaminated N-succinyl-chitosan as a liver-specific drug carrier in mice

Influence of the Chemical Structure and Physicochemical Properties of Chitin- and Chitosan-Based Materials on Their Biomedical Activity

“…For example, Kato et al evaluated the potential of lactosaminated N-succinyl-chitosan (Lac-Suc) as a liver-specific drug carrier (Kato et al, 2001). More recently, Yang et al prepared polyion complex micelles (PIC micelles), also for liver-targeted delivery (Yang et al, 2009a).…”

Endostatin-Encapsulated N-Succinyl-Chitosan Nanoparticles Inhabited the Growth of MCF-7 Cell

“…N-succinyl-chitosan (NSC), synthesized via introduction of succinyl groups at the N-position of the glucosamine unit of chitosan, is a water-soluble derivative with the same bioactivity of chitosan. Many reports focused their attention on the application of NSC as a carrier for protein, peptide and gene in cancer therapy [6] [7].…”

Approaches for Functional Modification or Cross‐Linking of Chitosan

“…Thus, in the current chapter, an overview on the drug delivery applications of cross-linked [23] and chemically modified chitosan is given. Important modified and cross-linked derivatives include carboxymethyl-chitosan (CMC), O-carboxymethyl-chitosan (O-CMC), N,O-carboxymethyl-chitosan (N,O-CMC) and N-carboxymethyl-chitosan (N-CMC) [14][15][16][17][18][19], succinylchitosan [24][25][26][27][28][29][30][31][32], thiolated chitosan [33][34][35][36][37][38][39][40][41][42][43], and chitosan grafted with PNIPAAm and PNVCL (chitosang-PNIPAAm and chitosan-g-PNVCL) [44][45][46][47].…”