Biological and Mechanical Properties of Denture Base Material as a Vehicle for Novel Hydroxyapatite Nanoparticles Loaded with Drug

Elboraey, Asmaa N.; Abo-Almaged, H.H.; El-Ashmawy, Ahmed A.; Abdou, Aya R.; Moussa, Amani; Emara, Laila H.; El-Masry, Hossam Mohammed; El‐Bassyouni, Gehan T.; Ramzy, Magda

doi:10.34172/apb.2021.009

Cited by 26 publications

(24 citation statements)

References 45 publications

(58 reference statements)

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“…Comparing the hardness values obtained for the HP and AP specimens, the lower values for the AP specimens were due to the presence of residual monomers, which act as a plasticizer and induce poor mechanical properties and low scratch resistance ( Gad et al, 2017b , Xu and Burgess, 2003 ). Elboraey et al, (2020) found a decrease in hardness with the addition of hydroxyapatite nanoparticles (HA-NP), which does not agree with the finding of the present study. The different results may be due to differences in filler type, size, and concentrations used in these studies.…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of the effectiveness of bioactive glass fillers against Candida albicans adhesion to PMMA denture base materials: An in vitro study

Gad

Abu-Rashid

Alkhaldi

et al. 2022

The Saudi Dental Journal

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Section: Discussioncontrasting

confidence: 99%

Evaluation of the effectiveness of bioactive glass fillers against Candida albicans adhesion to PMMA denture base materials: An in vitro study

Gad

Abu-Rashid

Alkhaldi

et al. 2022

The Saudi Dental Journal

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“…Specimens were applied on the selected microorganisms ( Bacillus subtilis (+) (ATCC 6633), Staphylococcus aureus (+) (ATCC 6538), Escherichia coli (−) (ATCC 2592), Pseudomonas aeruginosa (−) (ATCC 27853) and Candida albicans (Yeast) (ATCC 10231) utilizing shake cup technique to ascertain the antimicrobial properties through (%) decrease of these microorganisms inclusion with the microorganisms contrasted with the quantity of the microorganism's cells before the inclusion (control) for 24 hr period 14 . The level of pathogenic microorganism decrease after contact with the selected microorganisms was estimated utilizing spectrophotometer (Perkin‐Elmer Lambda EZ 201 UV–Vis‐USA) and contrasted to control bacterial strain.…”

Section: Methodsmentioning

confidence: 99%

“…decrease of these microorganisms inclusion with the microorganisms contrasted with the quantity of the microorganism's cells before the inclusion (control) for 24 hr period. 14 The level of pathogenic microorganism decrease after contact with the selected microorganisms was estimated utilizing spectrophotometer (Perkin-Elmer Lambda EZ 201 UV-Vis-USA) and contrasted to control bacterial strain.…”

Section: Biomineralizationmentioning

confidence: 99%

Radiological evaluations of low cost wollastonite nano‐ceramics graft doped with iron oxide in the treatment of induced defects in canine mandible

et al. 2020

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Wollastonite with/without maghemite [(Fe2O3), 0, 3 and 10 wt%] was prepared by facile wet precipitation method. Effect of Fe2O3 presence in the obtained nano‐ceramics on physical structure, morphology, size and the mechanical features was evaluated using X‐ray diffraction, transmission electron microscope, and universal testing machine. Moreover, the in vitro biomineralization was examined using simulated body fluid (SBF) by means of scanning electron microscope/energy dispersive X‐ray, Fourier transform infrared, and inductively coupled plasma. An in vivo study was conducted on 24 adult male mongrel dogs to test the biosafety of fabricated samples in the reconstruction of experimentally induced mandibular bone defects. Bone density was measured through cone beam computed tomography analysis conducted at 1 and 3 months following surgery. Wollastonite was the main phase in all the prepared samples however little maghemite was developed in Fe‐containing samples. No remarkable changes were recognized for physical structure of obtained microcrystalline structures, however, a decrease in particle size was noted in the existence of Fe2O3 (10‐15 nm) when compared to the pure wollastonite (30–50 nm). Mechanical features were dependent on the included Fe2O3 concentration within the wollastonite ceramic matrix. The degree of biomineralization of the samples immersed in SBF was elevated with the increase in Fe2O3 percentage. Clinically, the reconstruction of bone defects was uneventful without any adverse toxic effect. Bone density was significantly increased at 1 and 3 months (p < .001) in grafted defects compared to control ones. Increasing the doping concentrations of iron oxide was associated with significant increase (p < .001) of bone density in all induced defects. Due to the impressive healing effect of current fabricated nano‐ceramics, they are recommended to be utilized as low cost bone graft alternatives.

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“…Based on the idea that hydroxyapatite is a biocompatible and biodegradable naturally existent material in bones and teeth, Elboraey et al 22 aimed to develop biodegradable HA-NP that are capable of acting as carriers for metronidazole (MZ) within denture base resin in an attempt to manage oral infections. The results were promising in which there was a sustained release of MZ for up to 1 month.…”

Section: Hydroxyapatite Nanoparticlesmentioning

confidence: 99%

“…The excessive unreacted monomer acts as a plasticizer that allows the deformation of the material under load. 22…”

Section: Physical Properties Of Rechargeable Denture Base (Mechanical...mentioning

confidence: 99%

Highlights on Drug and Ion Release and Recharge Capacity of Antimicrobial Removable Prostheses

Abualsaud

Gad

2022

Eur J Dent

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This article aimed to review the ion and drug release, recharge abilities, and antimicrobial properties of drug/ion-releasing removable prostheses, and to assess their capability in preventing and inhibiting denture stomatitis as well preventing caries and reversing carious lesions. Data was collected from published scientific papers listed in PubMed database from January 1975 to December 2021. English full-text articles, involving clinical or in vitro studies, focusing on removable prostheses and are concerned with drug/ion release and rechargeability as a way to prevent or inhibit denture stomatitis or dental caries were included. The relevant articles reported that ion- or drug-modified polymethylmethacrylate acts as a reservoir for these ions and drugs and is capable of releasing significant amounts with sustained release effect. Recharging of modified resin resulted in greater sustainability of ion and drug release, thus improving the long-term effects of protection against demineralization and reducing the adhesion of Streptococcus mutans and Candida albicans. Modifications of removable prostheses with rechargeable ions and drugs enhance remineralization, hinder demineralization, and reduce microbial adhesion in difficult-to-access areas. Selection of denture base for clinical use will consider its ability to act as an ion/drug reservoir that is capable of release and recharge.

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Biological and Mechanical Properties of Denture Base Material as a Vehicle for Novel Hydroxyapatite Nanoparticles Loaded with Drug

Cited by 26 publications

References 45 publications

Evaluation of the effectiveness of bioactive glass fillers against Candida albicans adhesion to PMMA denture base materials: An in vitro study

Evaluation of the effectiveness of bioactive glass fillers against Candida albicans adhesion to PMMA denture base materials: An in vitro study

Radiological evaluations of low cost wollastonite nano‐ceramics graft doped with iron oxide in the treatment of induced defects in canine mandible

Highlights on Drug and Ion Release and Recharge Capacity of Antimicrobial Removable Prostheses

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