Biological and immunological activity of prothrombin in rough and smooth microsomes isolated from rat liver

Janson, T.L.; Helgeland, L.

doi:10.1016/0005-2795(75)90166-x

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Factor Ii: Prothrombin1

Introduction1

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1978

1982

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Cited by 12 publications

(2 citation statements)

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“…A prothrombin derivative in human urine was characterized by means of antibodies to prothrombin fragment 1 [192]. Activation of pro thrombin in insects was characterized by immuno chemical, biochemical and physiologic methods [193], and prothrombin precursors were identified in rat liver by means of antibodies raised against prothrombin [194,195].…”

Section: Factor Ii: Prothrombinmentioning

confidence: 99%

Antibody Technics and Blood Coagulation

Hassouna¹,

Penner

1981

Semin Thromb Hemost

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Section: Factor Ii: Prothrombinmentioning

confidence: 99%

Antibody Technics and Blood Coagulation

Hassouna¹,

Penner

1981

Semin Thromb Hemost

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“…The best investigated vitamin K-dependent factor is prothrombin. Its protein moiety (F IId) is synthesized in a ribosomal step in the hepatocytes [6]. In a second postribosomal step, 10 y-glutamic acids are synthesized on the NHa-terminal side of prothrombin by vitamin K-dependent carboxylation (FIIc) [14].…”

Section: Introductionmentioning

confidence: 99%

Prothrombin determination in plasma and in liver biopsies in chronic liver diseases

1982

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Following ribosomal synthesis of the protein moiety of prothrombin, postribosomal carboxylation in the liver is necessary to obtain prothrombin ready for physiologic activation. Both decarboxyprothrombin and carboxyprothrombin can be determined by means of specific activators. Using synthetic substrates for thrombin, a micro-prothrombin assay suitable for functional determinations of decarboxy- and carboxy-prothrombin in liver biopsies was evolved. Decarboxyprothrombin was not found in plasma, independent of the kind of liver disease. Prothrombin determination in 31 liver samples showed no relation between the absolute concentration of carboxyprothrombin and decarboxyprothrombin and the kind of disease. The carboxyprothrombin fraction of total prothrombin was correlated with the activity of histologically estimated fibrosis in the liver.

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Post-translational carboxylation of preprothrombin

Johnson¹

1981

The Biological Effects of Glutamic Acid and Its Derivatives

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Biological and immunological activity of prothrombin in rough and smooth microsomes isolated from rat liver

Cited by 12 publications

References 20 publications

Antibody Technics and Blood Coagulation

Antibody Technics and Blood Coagulation

Prothrombin determination in plasma and in liver biopsies in chronic liver diseases

Post-translational carboxylation of preprothrombin

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