2016
DOI: 10.18632/aging.101004
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Abstract: The onset of Alzheimer disease (AD) is influenced by several risk factors comprising diabetes. Within this context, antidiabetic drugs, including metformin, are investigated for their effect on AD. We report that in the C57B6/J mice, metformin is delivered to the brain where activates AMP-activated kinase (AMPK), its molecular target. This drug affects the levels of β-secretase (BACE1) and β-amyloid precursor protein (APP), promoting processing and aggregation of β-amyloid (Aβ), mainly in the cortex region. Mo… Show more

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Cited by 42 publications
(29 citation statements)
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References 56 publications
(75 reference statements)
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“…Aβ accumulation is the main pathology of AD, which can cause the cascade reaction and induce neural apoptosis [31]. Studies have shown that metformin is beneficial for AD patients [10][11][12]. In this experiment, we further investigated the neuroprotective mechanism of metformin on APP/PS1 mice.…”
Section: Oxidative Medicine and Cellular Longevitymentioning
confidence: 99%
See 2 more Smart Citations
“…Aβ accumulation is the main pathology of AD, which can cause the cascade reaction and induce neural apoptosis [31]. Studies have shown that metformin is beneficial for AD patients [10][11][12]. In this experiment, we further investigated the neuroprotective mechanism of metformin on APP/PS1 mice.…”
Section: Oxidative Medicine and Cellular Longevitymentioning
confidence: 99%
“…Diabetes mellitus (DM) is also associated with a higher risk of AD [9,10], in which insulin deficiency or insulin resistance may be responsible. Metformin, as a major antidiabetic drug, has been demonstrated to reduce β-secretase activity, promote phospho-thr-231-tau degradation, and influence mitochondrial function [10][11][12][13][14].…”
Section: Introductionmentioning
confidence: 99%
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“…Biguanides, including metformin and phenformin, are inhibitors of mitochondrial respiratory chain complex I, and have been shown to exhibit antitumor effects. [1][2][3][4][5][6][7] Metformin is one of the most widely prescribed drugs for the treatment of type II diabetes. Both retrospective analyses and subsequent clinical trials support the beneficial effect of metformin in cancer prevention and treatment.…”
Section: Introductionmentioning
confidence: 99%
“…e authors revealed that metformin treatment of SH-SY5Y cells causes accumulation of autophagosomes resulting in an increased β-and c-secretases and Aβ generation (see Table 1) [76]. Moreover, Picone et al also studied the biological effects of AMPK activator metformin on the generation of Aβ and expression of APP and BACE1 and they found that AMPK activation increases Aβ, BACE1, and APP expression [77].…”
Section: Ampk and Aβ Metabolismmentioning
confidence: 99%