Biological and antipathogenic activities of ribosome-inactivating proteins from Phytolacca dioica L.

Iglesias, Rosario; Citores, Lucı́a; Ragucci, Sara; Russo, Rosita; Maro, Antimo Di; Ferreras, José M.

doi:10.1016/j.bbagen.2016.03.011

Cited by 40 publications

(73 citation statements)

References 57 publications

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“…The results indicated MbRIP-1 showed significant antifungal activity against Aspergillus niger ( Kushwaha et al, 2012 ). Recently, RIPs from Phytolacca dioica , dioicin 2 and PD-L4 inhibited the growth of the fungus Penicillium digitatum ( Iglesias et al, 2016 ). Novel type I RIPs isolated from oil palm ( Elaeis guineensis ) showed inhibition on Ganoderma boninense mycelial growth ( Sargolzaei et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The Plant Ribosome-Inactivating Proteins Play Important Roles in Defense against Pathogens and Insect Pest Attacks

et al. 2018

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Ribosome-inactivating proteins (RIPs) are toxic N-glycosidases that depurinate eukaryotic and prokaryotic rRNAs, thereby arresting protein synthesis during translation. RIPs are widely found in various plant species and within different tissues. It is demonstrated in vitro and in transgenic plants that RIPs have been connected to defense by antifungal, antibacterial, antiviral, and insecticidal activities. However, the mechanism of these effects is still not completely clear. There are a number of reviews of RIPs. However, there are no reviews on the biological functions of RIPs in defense against pathogens and insect pests. Therefore, in this report, we focused on the effect of RIPs from plants in defense against pathogens and insect pest attacks. First, we summarize the three different types of RIPs based on their physical properties. RIPs are generally distributed in plants. Then, we discuss the distribution of RIPs that are found in various plant species and in fungi, bacteria, algae, and animals. Various RIPs have shown unique bioactive properties including antibacterial, antifungal, antiviral, and insecticidal activity. Finally, we divided the discussion into the biological roles of RIPs in defense against bacteria, fungi, viruses, and insects. This review is focused on the role of plant RIPs in defense against bacteria, fungi, viruses, and insect attacks. The role of plant RIPs in defense against pathogens and insects is being comprehended currently. Future study utilizing transgenic technology approaches to study the mechanisms of RIPs will undoubtedly generate a better comprehending of the role of plant RIPs in defense against pathogens and insects. Discovering additional crosstalk mechanisms between RIPs and phytohormones or reactive oxygen species (ROS) against pathogen and insect infections will be a significant subject in the field of biotic stress study. These studies are helpful in revealing significance of genetic control that can be beneficial to engineer crops tolerance to biotic stress.

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Section: Introductionmentioning

confidence: 99%

The Plant Ribosome-Inactivating Proteins Play Important Roles in Defense against Pathogens and Insect Pest Attacks

et al. 2018

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“…Nonfungal (i.e., bacterial, plant, animal, and/or human) counterparts (Al-Mahrous et al 2011;Citores et al 2016;Iglesias et al 2016;Jiratchariyakul et al 2001;Ogawa 2016;Ouyang et al 2006;Sartim and Sampaio 2015;Singh et al 2016) of the various fungal proteins and peptides very often are endowed with biological activities qualitatively analogous to the fungal proteins and peptides, although the structural homology may not be extensive. However, some differences in biological activity may exist.…”

Section: Resultsmentioning

confidence: 99%

Fungal proteinaceous compounds with multiple biological activities

Cheung

Wong

et al. 2016

Appl Microbiol Biotechnol

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Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.

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“…Not only the expression change of diverse LOXs, in our study, the abundance of ribosome-inactivating protein 2 and HSP70 were also altered in response to MCMV infection. Homologous proteins of ribosome-inactivating protein from the genus Phytolacca were reported to mediate a broad-spectrum antipathogenic activities [47]. In addition, heat shock protein were revealed to act as one of the major chaperones and involved in plant immunity and stress responses [48].…”

Section: Stress Response-related Proteins Regulated By MCMV Infectionmentioning

confidence: 99%

Proteomic Changes during MCMV Infection Revealed by iTRAQ Quantitative Proteomic Analysis in Maize

Dang

Cheng

et al. 2019

IJMS

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Maize chlorotic mottle virus (MCMV) has been occurring frequently worldwide and causes severe yield losses in maize (Zea mays). To better investigate the destructive effects of MCMV infection on maize plants, isobaric tagging for relative and absolute quantitation (iTRAQ)-based comparative proteomic analysis was performed on MCMV infected maize cv. B73. A total of 972 differentially abundant proteins (DAPs), including 661 proteins with increased abundance and 311 proteins with reduced abundance, were identified in response to MCMV infection. Functional annotations of DAPs and measurement of photosynthetic activity revealed that photosynthesis was decreased, while the abundance of ribosomal proteins, proteins related to stress responses, oxidation-reduction and redox homeostasis was altered significantly during MCMV infection. Two DAPs, disulfide isomerases like protein ZmPDIL-1 and peroxiredoxin family protein ZmPrx5, were further analyzed for their roles during MCMV infection through cucumber mosaic virus-based virus-induced gene silencing (CMV-VIGS). The accumulation of MCMV was suppressed in ZmPDIL-1-silenced or ZmPrx5-silenced B73 maize, suggesting ZmPDIL-1 and ZmPrx5 might enhance host susceptibility to MCMV infection.

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Biological and antipathogenic activities of ribosome-inactivating proteins from Phytolacca dioica L.

Cited by 40 publications

References 57 publications

The Plant Ribosome-Inactivating Proteins Play Important Roles in Defense against Pathogens and Insect Pest Attacks

The Plant Ribosome-Inactivating Proteins Play Important Roles in Defense against Pathogens and Insect Pest Attacks

Fungal proteinaceous compounds with multiple biological activities

Proteomic Changes during MCMV Infection Revealed by iTRAQ Quantitative Proteomic Analysis in Maize

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