Biological and analytical applications of Schiff base metal complexes derived from salicylidene-4-aminoantipyrine and its derivatives: a review

Ebosie, Ngozi Patricia; Ogwuegbu, M. O. C.; Gerald, Onyedika; Onwumere, Fidelis C.

doi:10.1007/s13738-021-02265-1

Cited by 32 publications

(16 citation statements)

References 69 publications

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“…[1] Among a large variety of coordination compounds, special attention is paid to complexes of transition metals with Schiff base (SB) ligands. [2] They have a wide range of application in the fields of medicine; biology; bioinorganic chemistry [3] ; catalysis [4] ; pharmacological, [5] clinical, and analytical areas [6] ; material science; and in the formation of compounds with unusual properties. Among them, iron (II/III) SB complexes are the most intensively studied due to their antibacterial, [7] antifungal, [8] antivirus, [9] and anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Magnetic properties of the mononuclear iron (III) complexes with biphenyl‐disubstituted Schiff base ligand: EPR and SQUID study

Vorobeva

Starichenko

Груздев

et al. 2022

Applied Organom Chemis

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The magnetic features of the mononuclear iron (III) complexes [Fe(L)2]+X− with tridentate Schiff base ligands [where L is 4‐(4‐diphenylcarboxy)‐2′‐oxysalicylidene‐N′‐ethylene‐N‐ethylene‐2′‐amine‐(carboxy‐4‐diphenyl) and X− = Cl− (1), PF6− (2) and NO3− (3) counter‐ions] have been studied by electron paramagnetic resonance (EPR) spectroscopy, SQUID (superconducting quantum interference device) magnetometry (solid), and Evans 1H nuclear magnetic resonance method (solution). EPR established that compounds (1) and (2) consist of two types high‐spin (HS, S = 5/2) centers with weak distorted and strong low‐symmetry octahedral crystal fields. The signals from low‐spin centers (LS, S = 1/2) of Fe (III) are observed in the spectra of compounds 2 and 3. SQUID revealed permanent HS behavior in (1) and mixed LS + HS in (2), (3) in wide temperature range, while solution method—only HS. Magnetic measurements allowed to estimate part of HS and LS fractions and detected antiferromagnetic exchange interactions between the neighboring Fe (III) ions in complexes.“

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Section: Introductionmentioning

confidence: 99%

Magnetic properties of the mononuclear iron (III) complexes with biphenyl‐disubstituted Schiff base ligand: EPR and SQUID study

Vorobeva

Starichenko

Груздев

et al. 2022

Applied Organom Chemis

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“…Schiff bases derived from this compound are acquired in good yields by the condensation reaction in the diverse organic solvents. [53][54][55][56][57][58][59] On the other hand, it is determined in some studies that these compounds also act as AChE and BChE inhibitors. [60,61] In this study, target molecules were synthesized in two steps.…”

Section: Introductionmentioning

confidence: 99%

Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety

Kamalı

Çakmak

Boğa

2022

J Chinese Chemical Soc

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In this research, nine novel heterocyclic Schiff base derivatives (10–18) bearing an aryl sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their inhibitory effects on acetyl‐ and butyrylcholinesterase (AChE and BChE) were investigated in vitro conditions. Moreover, their antioxidant activities were examined by DPPH and ABTS methods. The results indicated that some of the tested molecules had varying enzyme inhibition and antioxidant activities. We determined that compounds 8, 9, 14, 17, and 18 indicated inhibitory effects with IC50 values ranging from 89.30 to 111.28 μM against BChE, respectively compared to standard compound galanthamine (IC50 = 125.88 μM). On the other hand, of the molecules tested, only compound 5 (IC50 = 36.64 μM) displayed inhibitory activity higher than galanthamine against AChE. In DPPH assay, compounds 15 (IC50 = 161.93 μM), 16 (IC50 = 191.76 μM) and 17 (IC50 = 107.55 μM) showed higher antioxidant activity than BHT (IC50 = 203.50 μM). On the other hand, it was determined in ABTS assay that Schiff bases 10–17 (except for compound 18) indicated higher antioxidant activity than BHT.

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“…[7,8] The study of interaction between drugs and transition metals is an important and active research area in bioinorganic chemistry, also has analytical as well as biomedical applications. [9,10] Metal chelation affects significantly the antimicrobial/bioactive behavior of the organic ligands. [11,12] It is well known that the action of many drugs is dependent on its coordination with metal ions [13] or/and the inhibition on the formation of metalloenzymes is seen.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Co(II), Ni(II) and Zn(II) Metal Complexes Derived from a Hydrazone Schiff Base: Electrochemical Behavior and Comprehensive Biological Studies

et al. 2022

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The present study deals with the synthesis of (E)-N'-(2,5dimethoxybenzylidene)-2-hydroxybenzohydrazide, a hydrazone Schiff base ligand (HY) and its metal complexes [Co(HY) 2 , Ni(HY) 2 , Zn(HY) 2 ].2H 2 O. The structure of the synthesized ligand was characterized by physico-chemical analytical and spectral techniques. The electrochemical behavior of HY and its complexes were investigated by cyclic voltammetry. Infrared spectral data suggested that HY acts as a tridentate ligand with ONO as the donor atoms. Molar conductivity data showed that all the complexes were non-electrolytic in nature and octahedral geometry of the complexes was confirmed by UV-visible spectrum. TGA studies of the complexes gave a clear idea about the coordination sphere and the process of degradation.Further, HY and its complexes were screened for their in vitro antioxidant, antibacterial and anticancer activities. Among the synthesized complexes, Ni(II) and Zn(II) metal complexes showed prominent antioxidant activity investigated through their scavenging effect on DPPH radical, anticancer activity against MCF-7 and HeLa cancer cells. The molecular docking into P53 cancer mutant protein (PDB ID: 5AB9) was done for the optimization of the investigated compounds as potential cancer cell inhibitors. The observed data infer that all the complexes show promising antimicrobial activity against all of the tested bacterial and fungal species compared to the parent ligand HY.

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Biological and analytical applications of Schiff base metal complexes derived from salicylidene-4-aminoantipyrine and its derivatives: a review

Cited by 32 publications

References 69 publications

Magnetic properties of the mononuclear iron (III) complexes with biphenyl‐disubstituted Schiff base ligand: EPR and SQUID study

Magnetic properties of the mononuclear iron (III) complexes with biphenyl‐disubstituted Schiff base ligand: EPR and SQUID study

Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety

Synthesis of Co(II), Ni(II) and Zn(II) Metal Complexes Derived from a Hydrazone Schiff Base: Electrochemical Behavior and Comprehensive Biological Studies

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