Biological activity of ruthenium nitrosyl complexes

Chromatographic Investigation of Ruthenium Nitrosyl Complex: No Interconversion and Reactions With Biological Reductants

“…[1][2][3][4][5][6] Due to this, ruthenium nitrosyl complexes have emerged as an efficient system for the design of NO donors with potential pharmacological applications. [7][8][9][10] The most common synthetic route to prepare ruthenium nitrosyl complexes is based on the conversion of coordinated NO 2 -into NO + . 10 However, as far as we are concerned, a careful monitoring of this reaction using HPLC has never been reported in literature.…”

Isoindole and isomeric heterocyclic donating substituents in ruthenium(II)nitrosyl complexes with large first hyperpolarizabilities and potential two-photon absorption capabilities: a computational approach

“…For instance, nitric oxide (NO·), which plays a key role in numerous physiological and pathological processes such as blood pressure regulation, immune response, neurotransmission, or respiration [9], has also been recognized for its cytotoxic activity in tumor cells by apoptosis [10], and therefore the search for efficient NO· donor has become an active research domain, especially in the class of ruthenium(II) nitrosyl complexes [11][12][13][14].…”

Nitric oxide releasing-dendrimers: an overview

“…There are some representative chemical classes of NO-donors (Figure 1), as S-nitrosothiols (RSNOs), diazeniumdiolates (NONOates), organic nitrates and nitrites, and metal nitrosyl complexes, which were recently reviewed (Miller, Megson, 2007;Keefer, 2011;Tfouni et al, 2012;Serafim et al, 2012).…”

“…This last topic includes as examples the protection of myocardium against ischemia/reperfusion injuries (Chan, 2002;Webb et al, 2004;Schulz, Kelm, Heusch, 2004), toxicity toward cancer cells (Osti et al, 2012;Serafim et al, 2012), trypanocidal and leishmanicidal activities (Silva et al, 2007(Silva et al, , 2009Pereira et al, 2010;Guedes et al, 2010;Tfouni et al, 2012).…”