Biological Activities of Hydrazone Derivatives in the New Millennium

Abstract

ABSTRACT:Hydrazones are present in many of the bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. This created interest in researchers who have synthesized variety of hydrazone derivatives and screened them for their various biological activities viz. anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, anticancer, vasodialator, antiviral, antischistosomiasis, anti-HIV, anthelmintic, antidiabetic and trypanocidal activities. Hydrazones possessing an azometine -NHN=CH-proton constitute an important class of compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

“…They are known to possess a broad spectrum of biological activities such as antioxidant, analgesic, antiplatelet, antimicrobial, anticonvulsant, antidepressant, anti-inammatory, anti-tubercular, cardio protective, anti-HIV, anthelmintic, anti-diabetic, trypanocidal and anticancer activities. [1][2][3][4][5][6] Many of these compounds were patented in this respect. 7 Monohydrazide derivatives of carbonic and thiocarbonic acid, semicarbazide and thiosemicarbazide, respectively react with N-heteroaromatic carbonyl compounds giving (thio)semicarbazones -molecules well described as tridentate NNO(S) chelators and ribonucleotid reductase (RR) inhibitory agents.…”

“…All NMR spectral measurements were performed on a Bruker Avance III 500 spectrometer equipped with a broad-band direct probe. The spectra were recorded at room temperature in DMSO-d 6 (Table S1, ESI †).…”

Thionyl Chloride Catalyzed Synthesis and Antimicrobial Activities of Some 2-Benzylidene-1-Tosylhydrazines

“…Hydrazones and hydrazides are currently a significant class of therapeutically active compounds. 2,3 The suitable intermediates are produced by the heterocyclic hydrazone compounds like thiazolidin-4-one 4 or 1, 3-benzothiazin-4-one. 5 Hydrazones can act as polydentate ligands, depending on the nature of the attached group of hydrazone substituent.…”

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

“…Iproniazid, like isoniazid is used in the treatment of tuberculosis (TB) and also showed antidepressant effect. Another effective hydrazidehydrazones is nifuroxazide, which is used as an intestinal antiseptic (Negi et al, 2012;Rollas and Kucukguzel. 2007).…”