Biologic significance of polyunsaturated fatty acids in the skin

Ziboh, V. A.

doi:10.1001/archderm.123.12.1686a

Cited by 24 publications

(9 citation statements)

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“…As the skin does not have stocks of FA and renews quickly, it becomes dependent on the continuous supply of these FA from the diet. In this sense, FA generated from hepatic elongation and desaturation are available to incorporation into skin cell membranes . In this sense, our present findings confirm that this type of skin FA may be modified by supplementation and/or dietary manipulations.…”

Section: Discussionsupporting

confidence: 83%

Influence of Trans Fat on Skin Damage in First‐Generation Rats Exposed to UV Radiation

Barcelos

Vey

Segat

et al. 2015

Photochem & Photobiology

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The influence of trans fatty acids (TFA) on lipid profile, oxidative damage and mitochondrial function in the skin of rats exposed to ultraviolet radiation (UVR) was assessed. The first-generation offspring of female Wistar rats supplemented from pregnancy with either soybean oil (C-SO, rich in n-6 FA; control group) or hydrogenated vegetable fat (HVF, rich in TFA) were continued with the same supplements until adulthood, when half of each group was exposed to UVR for 12 weeks. The HVF group showed higher TFA cutaneous incorporation, increased protein carbonyl (PC) levels, decreased functionality of mitochondrial enzymes and antioxidant defenses of the skin. After UVR, the HVF group showed increased skin thickness and reactive species (RS) generation, with decreased skin antioxidant defenses. RS generation was positively correlated with skin thickness, wrinkles and PC levels. Once incorporated to skin, TFA make it more susceptible to developing UVR-induced disorders.

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Section: Discussionsupporting

confidence: 83%

Influence of Trans Fat on Skin Damage in First‐Generation Rats Exposed to UV Radiation

Barcelos

Vey

Segat

et al. 2015

Photochem & Photobiology

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“…Topical application of lipids is normally used to prevent skin water loss. It is well recognized that ω-6 polyunsaturated fatty acids, and especially the C-18 fatty acids, such as linoleic acid (1) and γ-linolenic acid (2) have a capacity to restore transepidermal water loss (TEWL) to normal (Ziboh and Chapkin, 1987). Thus, the formulations comprising oil-inwater emulsion containing ingredients which can retain the water in the skin are used to prevent excessive loss of water from the skin.…”

Section: Active Ingredients For Moisturizermentioning

confidence: 99%

The Potential of Marine Resources in Cosmetics

Alparslan¹,

Şekeroğlu

Kijjoa³

2018

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

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The Ocean is a continuous body of saltwater that covers more than 70 percent of the Earth's surface. Despite the fact that oceanic habitats exhibit chemical and physical properties that make certain ocean zones suitable or unsuitable places for different species to live, the chemical (salinity and dissolved gases) and physical (temperature, density, buoyancy, waves, tides, and currents) properties of ocean water are delicately intermingled which produce one of the most self-sustaining life support systems on earth. This unique characteristic has made the marine environment an untapped source of bioactive natural products with unique structural and chemical features. Although many marine-derived compounds have been explored for their potential in pharmaceutical industry and some of which are already on the market, these molecules are still underexplored for natural cosmetics when compared to plant-derived compounds. However, recently many cosmetic firms have turned their attention to the sea to obtain several kinds of marine-derived compounds for cosmetic ingredients such as moisturizer, anti-ageing, photoprotection and skin whitening agents. With more research on the small molecules, biopolymers and enzymes from the marine environment, it is expected that the era of "blue cosmetics" will be dominating this sector very soon.

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“…Dietary FO supplementation (FOS) can increase EPA/DHA relative to AA in cellular membranes, and thereby reduce free AA and subsequently AA-derived eicosanoids such as PGE 2 (Black and Rhodes, 2016). FOS has been studied for its potential beneficial effects on certain skin diseases, such as skin squamous cell cancer and psoriasis (Black and Rhodes, 2016;Talbott and Duffy, 2015;Ziboh and Chapkin, 1987).…”

Section: To the Editormentioning

confidence: 99%