2011
DOI: 10.1007/s00464-011-1700-7
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Abstract: At 2 months, cross-linked and non-cross-linked biologic hernia implants were poorly integrated. Cross-linking led to a more pronounced foreign body reaction. Less inflammatory response may reduce local complications, but did not enhance implant integration in this study.

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Cited by 23 publications
(20 citation statements)
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“…9,10 Although clinical circumstances requiring longterm tissue reinforcement may provide some utility for a cross-linked graft, it is clear that such meshes display a significant immunologic disadvantage that likely translates into poor performance in a clinical setting, especially in the face of contamination. [12][13][14][15] …”
Section: Collagen Cross-linkingmentioning
confidence: 98%
“…9,10 Although clinical circumstances requiring longterm tissue reinforcement may provide some utility for a cross-linked graft, it is clear that such meshes display a significant immunologic disadvantage that likely translates into poor performance in a clinical setting, especially in the face of contamination. [12][13][14][15] …”
Section: Collagen Cross-linkingmentioning
confidence: 98%
“…15 This in turn may hinder mesh integration into native tissue. 50 Cross-linked porcine acellular dermal matrix generates a persistent granulomatous reaction when implanted in a rat ventral hernia model that resulted in poor integration into nearby musculofascia. 50 In a study comparing cross-linked CollaMend to noncross-linked Strattice, neither material demonstrated adhesions to bowel or solid organs, but the cross-linked material resulted in omental adhesions with significantly greater tenacity grade and surface area.…”
Section: Smentioning
confidence: 99%
“…In einem weiteren Narbenhernien-Rattenmodell war aber PTFE und Non-Cross-linked-Rinderperikard gegenüber Fascia lata überlegen [25]. In einem experimentellen offenen IPOM-Modell (Ratte) wurde für 4 biologische Implantate nach 60 Tagen eine insuffiziente Gewebeintegration für alle Varianten dokumentiert, wobei allerdings Tutomesh ® (neben Peripatch ® ) am wenigsten adhäsiv war und die geringste Fremdkörperreaktion aufwies [26]. In Bezug auf das Cross-linking (2 Cross-linked-/2 Non-Cross-linked-Implantate) wurden keine Vorteile hinsichtlich einer besseren Gewebeintegration beschrieben.…”
Section: Adhäsionsgradunclassified
“…2 F max und dL der verschiedenen Proben. nutztes Implantat für die paraösophageale Applikation, wurde der vorbekannte erhebliche Schrumpfungsprozess bestätigt und von dieser Arbeitsgruppe als Abstoßungsreaktion gewertet [26].…”
Section: Adhäsionsgradunclassified
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