Biologic characteristics of esophageal epithelial dysplasia assessed by proliferating cell nuclear antigen

Abstract

PCNA expression may be a useful marker to reflect the biologic characteristics of esophageal dysplasia, suggesting that a high grade of dysplasia is as serious a lesion as esophageal carcinoma.

Histological and biological characteristics of esophageal dysplasia

“…In this study, we estimated the cell proliferative activity and carcinogenesis of esophageal dysplastic lesions using PCNA analysis [10]. PCNA was first reported as one of the nuclear antigens reacting with an autoantibody in the sera of patients with systemic lupus erythematosus.…”

“…The PCNA LI is expressed as a percentage of the positive cells [10]. In normal epithelium, the PCNA LI was low (7.5% ± 4.1%) in the basal layer, and about 17.3% ± 7.3% in the parabasal layer (Table 3).…”

Histological and biological characteristics of esophageal dysplasia

“…In this study, we estimated the cell proliferative activity and carcinogenesis of esophageal dysplastic lesions using PCNA analysis [10]. PCNA was first reported as one of the nuclear antigens reacting with an autoantibody in the sera of patients with systemic lupus erythematosus.…”

“…The PCNA LI is expressed as a percentage of the positive cells [10]. In normal epithelium, the PCNA LI was low (7.5% ± 4.1%) in the basal layer, and about 17.3% ± 7.3% in the parabasal layer (Table 3).…”

Prognostic Value of p53, Proliferating cell Nuclear Antigen, and Ki‐67 Expression in Undifferentiated Nasopharyngeal Carcinomas

“…PCNA expression has been considered to reflect the proliferation rate of tumor cells and has been suggested as a prognostic indicator in several neoplasms 5,25,26 . Additionally, a strong correlation between p53 levels and PCNA expression has been described for esophageal carcinoma and astrocytic neoplasms 27,28 .…”

In situ hybridization for the detection of telomerase RNA in the progression from barrett's esophagus to esophageal adenocarcinoma

“…Autoradiographic studies utilizing tritiated thymidine reported an increase in the population of proliferative cells in some patients with Barrett's metaplasia. 14 In addition, immunohistochemical studies using antibodies against proliferation-associated antigens, such as proliferating cell nuclear antigen (PCNA) [15][16][17][18] and Ki-67, 19,20 reported a positive correlation between cell proliferation and increasing degrees of dysplasia in Barrett's epithelium. Other studies utilizing flow cytometric analysis to assess Ki-67 labeling, however, found no differences in Ki-67 expression among Barrett's without dysplasia, low grade dysplasia, high grade dysplasia, or adenocarcinoma.…”

Histological and biological characteristics of esophageal dysplasia

“…In this study, we estimated the cell proliferative activity and carcinogenesis of esophageal dysplastic lesions using PCNA analysis [10]. PCNA was first reported as one of the nuclear antigens reacting with an autoantibody in the sera of patients with systemic lupus erythematosus.…”

“…The PCNA LI is expressed as a percentage of the positive cells [10]. In normal epithelium, the PCNA LI was low (7.5% ± 4.1%) in the basal layer, and about 17.3% ± 7.3% in the parabasal layer (Table 3).…”

Prognostic Value of p53, Proliferating cell Nuclear Antigen, and Ki‐67 Expression in Undifferentiated Nasopharyngeal Carcinomas

“…PCNA expression has been considered to reflect the proliferation rate of tumor cells and has been suggested as a prognostic indicator in several neoplasms 5,25,26 . Additionally, a strong correlation between p53 levels and PCNA expression has been described for esophageal carcinoma and astrocytic neoplasms 27,28 .…”

In situ hybridization for the detection of telomerase RNA in the progression from barrett's esophagus to esophageal adenocarcinoma

“…Autoradiographic studies utilizing tritiated thymidine reported an increase in the population of proliferative cells in some patients with Barrett's metaplasia. 14 In addition, immunohistochemical studies using antibodies against proliferation-associated antigens, such as proliferating cell nuclear antigen (PCNA) [15][16][17][18] and Ki-67, 19,20 reported a positive correlation between cell proliferation and increasing degrees of dysplasia in Barrett's epithelium. Other studies utilizing flow cytometric analysis to assess Ki-67 labeling, however, found no differences in Ki-67 expression among Barrett's without dysplasia, low grade dysplasia, high grade dysplasia, or adenocarcinoma.…”

Histological and biological characteristics of esophageal dysplasia

“…In this study, we estimated the cell proliferative activity and carcinogenesis of esophageal dysplastic lesions using PCNA analysis [10]. PCNA was first reported as one of the nuclear antigens reacting with an autoantibody in the sera of patients with systemic lupus erythematosus.…”

“…The PCNA LI is expressed as a percentage of the positive cells [10]. In normal epithelium, the PCNA LI was low (7.5% ± 4.1%) in the basal layer, and about 17.3% ± 7.3% in the parabasal layer (Table 3).…”

Prognostic Value of p53, Proliferating cell Nuclear Antigen, and Ki‐67 Expression in Undifferentiated Nasopharyngeal Carcinomas

“…PCNA expression has been considered to reflect the proliferation rate of tumor cells and has been suggested as a prognostic indicator in several neoplasms 5,25,26 . Additionally, a strong correlation between p53 levels and PCNA expression has been described for esophageal carcinoma and astrocytic neoplasms 27,28 .…”

In situ hybridization for the detection of telomerase RNA in the progression from barrett's esophagus to esophageal adenocarcinoma

“…Autoradiographic studies utilizing tritiated thymidine reported an increase in the population of proliferative cells in some patients with Barrett's metaplasia. 14 In addition, immunohistochemical studies using antibodies against proliferation-associated antigens, such as proliferating cell nuclear antigen (PCNA) [15][16][17][18] and Ki-67, 19,20 reported a positive correlation between cell proliferation and increasing degrees of dysplasia in Barrett's epithelium. Other studies utilizing flow cytometric analysis to assess Ki-67 labeling, however, found no differences in Ki-67 expression among Barrett's without dysplasia, low grade dysplasia, high grade dysplasia, or adenocarcinoma.…”