Biokinetics, dosimetry, and radiation risk in infants after 99mTc-MAG3 scans

Machado, J. Soares; Tran-Gia, Johannes; Schlögl, Susanne; Buck, Andreas K.; Laßmann, Michael

doi:10.1186/s13550-017-0356-2

Cited by 7 publications

(6 citation statements)

References 20 publications

(36 reference statements)

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“…In another study, Machado et al . used similar methods and calculated the absorbed doses in infant patients (1.6–11.0 months) which was 0.3 ± 0.2 mGy with injected activity of 17.4 MBq 99m Tc-MAG3, and ovarian dose per unit activity was 1.72 E-02 ± 1.14E-02 mGy/MBq [17]. The calculated absorbed doses from injected radiotracer in our study are comparable with these published studies.…”

Section: Discussionsupporting

confidence: 83%

“…NCINM 2.0 software was used in our study to calculate the internal gonadal dose. A limitation of this method is that NCINM 2.0 is based on the ICRP 80 publication which only provides biokinetic data for pediatric patients 1 year of age and older (6,17). We applied biokinetic data of 1-year-old from NCINM 2.0 to the 0-year phantom in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Estimation of organ doses of infants and children need to be based on age-specific phantoms and pediatric biokinetic data. There have been studies on the organ absorbed doses irradiated from injected activities during 99m Tc-MAG3 renal scans in pediatric patients [17,18]. However, calculating organ dose irradiated from external source like diapers has not yet been explored to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of infant gonadal dose irradiated from urine-contaminated diapers during diuretic renal scintigraphy

Lu,

Kumbhar,

Liu

et al. 2023

Nuclear Medicine Communications

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Objective To estimate the gonadal doses irradiated from urine- contaminated diapers during diuretic renal scintigraphy. Methods Images of 31 patients (18 males and 13 females) with urine-contaminated diapers during 99mTc-MAG3 renal scintigraphy were analyzed. The count rate of the diapers was converted into a time-activity curve based on the calibrated factor of the gamma camera system. The cumulative activity was determined from the area under the curve. By incorporating dose per unit cumulative activity pre-calculated from Monte Carlo simulation with 0-year phantom, the gonadal dose irradiated from diaper was calculated. To assess the degree of this additionally introduced dose from diapers, the calculated gonadal dose was compared to the internal gonadal dose from injected radiotracer activity. Results The cumulative activities irradiated from urine-contaminated diapers were 1.12 E04 ± 1.29E04 MBq.s in male infants, which was nearly half of the 1.94 E04 ± 1.80E04 MBq.s (P = 0.15) in female infants. However, the absorbed doses for testes in male infants were 7.37E-01 ± 8.50E-01 mGy, which was approximately 10 times the 6.38E-02 ± 5.94E-02 mGy for ovaries in female infants (P < 0.01). The diaper-introduced dose for testes and ovaries was 91.7% and 3.9% of the gonadal doses from the injected activity in patients with normal renal function, and 99.0% and 4.3% of those in patients with abnormal renal function. Conclusion Urine-contaminated diapers introduced additional radiation doses to infant patients during 99mTc-MAG3 renal scintigraphy. The gonadal doses were of significance in male infants who had nearly double the absorbed dose for the testes.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of infant gonadal dose irradiated from urine-contaminated diapers during diuretic renal scintigraphy

Lu,

Kumbhar,

Liu

et al. 2023

Nuclear Medicine Communications

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“…Following publication of the original article [ 1 ], the authors identified several calculation errors in the second and seventh paragraphs of the discussion section.…”

Section: Correction To: Ejnmmi Research (2018) 8:10 Https://doiorg/101186/s13550-017-0356-2mentioning

confidence: 99%

Correction to: Biokinetics, dosimetry and radiation risk in infants after 99mTc-MAG3 scans

et al. 2021

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“…Diethylenetriamine pentaacetic acid (DTPA) renal scan is a procedure which involves minimal but some radiation exposure. [ 5 6 ] Hence, how long to follow these patients with renal scan and minimum number of scans required for follow-up? We try to answer these questions through this prospective observational study.…”

Section: Introductionmentioning

confidence: 99%

To evaluate the minimum number of renal scans required to follow pediatric patient postpyeloplasty

Verma¹,

Saxena²,

Singh

et al. 2020

World J Nucl Med

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The aim of the study is to evaluate the minimum number of renal scans required to follow pediatric patients postpyeloplasty. We prospectively reviewed the renal scans of 145 children with unilateral pelvi-ureteric junction obstruction who underwent dismembered pyeloplasty. Patients were then divided into four groups based on preoperative split renal function. All patients were followed with renal scan and ultrasound for minimum of 4 years. Renal scan and ultrasound were done after stent removal at 3, 6, and 12 months and then yearly after surgery. Drainage pattern (T1/2) was seen in all groups, except in patients where there was no comment on drainage pattern. Statistical analysis was performed using the Friedman ANOVA and Wilcoxon signed-ranks test as a post hoc test with Bonferroni correction and Kruskal–Wallis test with Mann–Whitney U-test as a post hoc test with Bonferroni correction. On comparison of the pattern of drainage with time in Groups 1–4, it was found that there was no significant difference with time in Group 1. Then, further, using Wilcoxon signed-rank test as post hoc test for Friedman ANOVA, Group 2 showed statistically significant difference in drainage pattern in scans between 6 months and 1 year, Group 3 showed statistically significant difference in drainage pattern in scans between 3 months and 1 year, and Group 4 showed statistically significant difference in drainage pattern in scans done between 3 and 6 months ( P < 0.05). Minimum of three renal scans were required for paediatric patients post pyeloplasty at 3 months, 6 months and 1 year in the follow up period.

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Biokinetics, dosimetry, and radiation risk in infants after 99mTc-MAG3 scans

Cited by 7 publications

References 20 publications

Assessment of infant gonadal dose irradiated from urine-contaminated diapers during diuretic renal scintigraphy

Assessment of infant gonadal dose irradiated from urine-contaminated diapers during diuretic renal scintigraphy

Correction to: Biokinetics, dosimetry and radiation risk in infants after 99mTc-MAG3 scans

To evaluate the minimum number of renal scans required to follow pediatric patient postpyeloplasty

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