2016
DOI: 10.1038/nnano.2015.312
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Abstract: Peptide nanostructures are biodegradable and are suitable for many biomedical applications. However, to be useful imaging probes, the limited intrinsic optical properties of peptides must be overcome. Here we show the formation of tryptophan-phenylalanine dipeptide nanoparticles (DNPs) that can shift the peptide's intrinsic fluorescent signal from the ultraviolet to the visible range. The visible emission signal allows the DNPs to act as imaging and sensing probes. The peptide design is inspired by the red shi… Show more

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Cited by 310 publications
(203 citation statements)
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“…The experimental results have demonstrated that these nanostructures are biocompatible and photostable, except the blue color fluorescent properties with a narrow emission wavelength. Most importantly, these dipeptides self-assembled nanoparticles could conjugate with MUC1 aptamer and anticancer drug doxorubicin to target specific cancer cells for better delivery and cancer therapy applications [15]. These studies revealed the potential and advantages of using peptide self-assembled nanostructures for targeted drug delivery applications.…”
Section: Targeted Drug Deliverymentioning
confidence: 95%
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“…The experimental results have demonstrated that these nanostructures are biocompatible and photostable, except the blue color fluorescent properties with a narrow emission wavelength. Most importantly, these dipeptides self-assembled nanoparticles could conjugate with MUC1 aptamer and anticancer drug doxorubicin to target specific cancer cells for better delivery and cancer therapy applications [15]. These studies revealed the potential and advantages of using peptide self-assembled nanostructures for targeted drug delivery applications.…”
Section: Targeted Drug Deliverymentioning
confidence: 95%
“…Besides that, there are also many other proteins or aptamers that could be used to enhance cell penetrating or specific targeting especially for cancer cells or disease sites. For example, dipeptide WF self-assembled nanoparticles have been developed for targeted drug delivery for cancer therapy [15]. These peptide self-assembled nanoparticles have visible fluorescent properties compared to amino acids' intrinsic UV range fluorescent properties.…”
Section: Targeted Drug Deliverymentioning
confidence: 99%
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“…67 This is analogous to the self-assembly of some proteins, eg, the man-made spider silk protein, eADF4(C16), which forms microspheres at high concentrations of potassium phosphate (.400 mM) but forms nanofibers at low concentrations of potassium phosphate (,300 mM). 68 A common feature of the peptides that form nanoparticles is the presence of aromatic amino acid residues in their sequences, eg, Phe-Tyr, 69 Phe-Phe-Phe, 70 and various Trpbased oligopeptides derived from the truncation of gramicidin A. 71,72 Presumably, self-assembly of the peptides is facilitated …”
Section: Peptide Nanoparticles As Drug Delivery Agents and Bioimagingmentioning
confidence: 99%
“…Many peptides have strong metal coordination abilities, particularly basic amino acids. For example, Zhang and co‐workers reported the preparation of dipeptide nanoparticles by self‐assembly with zinc ions and their use in imaging and monitoring drug release in real time 14. Hence, we hypothesized that peptides are useful to deliver MMPIs due to their chelating ability.…”
Section: Introductionmentioning
confidence: 99%