Bioimaging Using the Optimized Nonlinear Optical Properties of ZnO Nanoparticles

Urban, Ben E.; Neogi, Purnima B.; Senthilkumar, K.; Rajpurohit, Surendra Kumar; Jagadeeshwaran, P.; Kim, Seong-Cheol; Fujita, Yasuhisa; Neogi, Arup

doi:10.1109/jstqe.2012.2184793

Cited by 32 publications

(22 citation statements)

References 29 publications

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“…Another interesting idea to control the NLO response was proposed in the work of Akl et al (2013). Based on DFT calculations, those authors showed that the photoswitching of GS to MS1 in ruthenium nitrosyl complexes can induce a significant change in the hyperpolarizability parameter and might therefore be useful for NLO applications based on the second harmonic, such as for bioimaging (Urban et al, 2012;Su et al, 2017). However, there are certain experimental conditions to be satisfied in order to show that NLO properties can be controlled by photoswitching of nitrosyl linkage isomers.…”

Section: Introductionmentioning

confidence: 99%

Combining photoinduced linkage isomerism and nonlinear optical properties in ruthenium nitrosyl complexes

Михайлов

Vuković

Kijatkin

et al. 2019

Acta Crystallogr Sect B

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The complex trans‐[RuNO(NH3)4F]SiF6 was synthesized in quantitative yield and the structure was characterized by X‐ray diffraction and spectroscopic methods. The complex crystallizes in the non‐centrosymmetric space group Pn. Hirshfeld surface analysis revealed that the dominant intermolecular interactions are of types H…F and F…O, which are likely to be responsible for the packing of the molecules in a non‐centrosymmetric structure. Irradiation with blue light leads to the formation of Ru–ON (metastable state MS1) and Ru–η2‐(NO) (metastable state MS2) bond isomers, as shown by IR and UV–Vis spectroscopy. The structural features of the MS1 isomer were elucidated by photocrystallography. The complex exhibits exceptionally good thermal stability of the metastable state MS1, such that it can be populated by light at 290–300 K, which is important for potential applications. The second harmonic (SH) emission can be generated by femtosecond‐pulsed irradiation of the complex. The generated SH is rather efficient and stable under long‐term exposure. Finally, since both metastable states and harmonic generation can be generated at room temperature, an attempt to drive the SH response by photoisomerization of the nitrosyl ligand was made and is discussed.

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Section: Introductionmentioning

confidence: 99%

Combining photoinduced linkage isomerism and nonlinear optical properties in ruthenium nitrosyl complexes

Михайлов

Vuković

Kijatkin

et al. 2019

Acta Crystallogr Sect B

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“…The nonlinear optical phenomena have wide-ranging applications e.g. in optical modulators, 3 biological imaging, 4 lasers, 5 linear and nonlinear optical signal processing, 6 quantum electronics and quantum information processing. 7 The semiconductor nanostructures possess large nonlinear susceptibility in comparison to their bulk counterpart.…”

Section: Introductionmentioning

confidence: 99%

“…18 As a consequence in QDs there is no requirement of phase matching condition between the fundamental and the second harmonic beams. 4,17,18 Consequently these attributes reveal QDs as a judicious choice for observing the nonlinear optical processes to open possibilities of new investigations in nonlinear optics. Such studies on the nonlinear optical processes in QDs could be envisioned for implementation in devices based on optical nonlinearity.…”

Section: Introductionmentioning

confidence: 99%

“…4,20 The nonlinear optical properties are reported for different forms of ZnO such as single crystals, thin films, nanowires and nano-ribbons. 14 The enhancement of the nonlinear optical properties as compared to bulk counterpart is observed for thin films.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the enhanced second and third order nonlinearity of ZnO nanoparticles has been utilized for the nonlinear in vitro imaging of the living cells. 4 To the best of our knowledge no studies are reported on the second order nonlinearity via quadrupole ISL transitions in the conduction band of ZnO QD.…”

Section: Introductionmentioning

confidence: 99%

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Quadrupole second harmonic generation and sum-frequency generation in ZnO quantum dots

2015

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The second harmonic generation (SHG) and the sum frequency generation (SFG) processes are investigated in the conduction band states of the singly charged ZnO quantum dot (QD) embedded in the HfO 2 , and the AlN matrices. With two optical fields of frequency ω p and ω q incident on the dot, we study the variation with frequency of the second order nonlinear polarization resulting in SHG and SFG, through the electric dipole and the electric quadrupole interactions of the pump fields with the electron in the dot. We obtain enhanced value of the second order nonlinear susceptibility in the dot compared to the bulk. The effective mass approximation with the finite confining barrier is used for obtaining the energy and wavefunctions of the quantized confined states of the electron in the conduction band of the dot. Our results show that both the SHG and SFG processes depend on the dot size, the surrounding matrix and the polarization states of the pump beams. C 2015 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License. [http://dx

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Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate

Karpf,

Glöckner Burmeister,

Dubreil

et al. 2024

Small

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The pre‐clinical validation of cell therapies requires monitoring the biodistribution of transplanted cells in tissues of host organisms. Real‐time detection of these cells in the circulatory system and identification of their aggregation state is a crucial piece of information, but necessitates deep penetration and fast imaging with high selectivity, subcellular resolution, and high throughput. In this study, multiphoton‐based in‐flow detection of human stem cells in whole, unfiltered blood is demonstrated in a microfluidic channel. The approach relies on a multiphoton microscope with diffractive scanning in the direction perpendicular to the flow via a rapidly wavelength‐swept laser. Stem cells are labeled with metal oxide harmonic nanoparticles. Thanks to their strong and quasi‐instantaneous second harmonic generation (SHG), an imaging rate in excess of 10 000 frames per second is achieved with pixel dwell times of 1 ns, a duration shorter than typical fluorescence lifetimes yet compatible with SHG. Through automated cell identification and segmentation, morphological features of each individual detected event are extracted and cell aggregates are distinguished from isolated cells. This combination of high‐speed multiphoton microscopy and high‐sensitivity SHG nanoparticle labeling in turbid media promises the detection of rare cells in the bloodstream for assessing novel cell‐based therapies.

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Bioimaging Using the Optimized Nonlinear Optical Properties of ZnO Nanoparticles

Cited by 32 publications

References 29 publications

Combining photoinduced linkage isomerism and nonlinear optical properties in ruthenium nitrosyl complexes

Combining photoinduced linkage isomerism and nonlinear optical properties in ruthenium nitrosyl complexes

Quadrupole second harmonic generation and sum-frequency generation in ZnO quantum dots

Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate

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