Biogenic Synthesis of Copper Nanoparticles: A Systematic Review of Their Features and Main Applications

Abstract

Nanotechnology is an innovative field of study that has made significant progress due to its potential versatility and wide range of applications, precisely because of the development of metal nanoparticles such as copper. Nanoparticles are bodies composed of a nanometric cluster of atoms (1–100 nm). Biogenic alternatives have replaced their chemical synthesis due to their environmental friendliness, dependability, sustainability, and low energy demand. This ecofriendly option has medical, pharmaceutical, food, and agricultural applications. When compared to their chemical counterparts, using biological agents, such as micro-organisms and plant extracts, as reducing and stabilizing agents has shown viability and acceptance. Therefore, it is a feasible alternative for rapid synthesis and scaling-up processes. Several research articles on the biogenic synthesis of copper nanoparticles have been published over the past decade. Still, none provided an organized, comprehensive overview of their properties and potential applications. Thus, this systematic review aims to assess research articles published over the past decade regarding the antioxidant, antitumor, antimicrobial, dye removal, and catalytic activities of biogenically synthesized copper nanoparticles using the scientific methodology of big data analytics. Plant extract and micro-organisms (bacteria and fungi) are addressed as biological agents. We intend to assist the scientific community in comprehending and locating helpful information for future research or application development.

Fungus Mediated Copper Oxide Nanoparticles against Fungi Isolated from Soft-rot Infected Ginger

“…The nanoparticles were analyzed with NTA, which showed that the particle average size was near 100 nm with a standard deviation of 34.9 nm. The results were in unison with the previous results (Kamble et al, 2015;Ingle et al, 2022;Luque-Jacobo et al, 2023). Zeta potential was observed in the stability range, indicating the synthesis of stable CuONPs that forms stable colloid at room temperature (Gaikwad et al, 2013;Gade et al, 2014).…”

Development of CuO Nanoparticles from the Mucus of Garden Snail Cornu aspersum as New Antimicrobial Agents

“…Many reports of antibacterial, antifungal, larvicidal, anti-termite [ 61 , 62 , 63 , 64 , 65 ], and anticancer [ 66 , 67 ] activities of CuONPs derived from plants, animals, and microorganisms. Furthermore, several studies conducted in recent years have demonstrated the advantages of employing snail mucus to synthesize Ag and AuNPs, which have been shown to have broad-spectrum antibacterial activity, anticancer potential, and anti-inflammatory properties [ 21 , 68 ].…”

Biosynthesis of Copper Nanoparticles with Medicinal Plants Extracts: From Extraction Methods to Applications

“…A wide range of precursor concentrations have been reported in the literature. For instance, copper chloride has been studied within a concentration range of 10 to 250 mM, copper nitrate from 0.1 to 100 mM, copper acetate from 3 to 500 mM, and copper sulfate from 1 to 1000 mM [86]. Subsequently, the reaction mixture is stirred to ensure thorough mixing with the metal precursor.…”