Biofunctionalization of commercially pure titanium with chitosan/hydroxyapatite biocomposite via silanization: evaluation of biological performances

Vyas, Veena; Kaur, Tejinder; Kar, Sumanta; Thirugnanam, A.

doi:10.1080/01694243.2016.1278070

Cited by 14 publications

(8 citation statements)

References 32 publications

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“…From the results, it is confirmed that the chitosan/AgSr-HA coatings are highly bioactive and have a strong ability to bind with the natural bone. The results obtained in the current study were in agreement with those in the literature …”

Section: Results and Discussionsupporting

confidence: 93%

Fabrication and Characterization of Ag–Sr-Substituted Hydroxyapatite/Chitosan Coatings Deposited via Electrophoretic Deposition: A Design of Experiment Study

et al. 2020

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In this study, silver–strontium-doped hydroxyapatite (AgSr-HA)/chitosan composite coatings were deposited on a 316L stainless steel (SS) substrate via electrophoretic deposition (EPD). The Taguchi design of experiment (DoE) approach was used to optimize the EPD parameters such as the applied voltage, interelectrode spacing, and deposition time. Furthermore, the concentration of AgSr-HA particles in the suspension was also optimized via the DoE approach. DoE results demonstrated that the “homogeneous” coatings were obtained at the deposition time of 7 min, deposition voltage of 20 V, and at a concentration of 5 g/L AgSr-HA particles in the suspension. Scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), antibacterial studies, contact angle, and roughness measurements were performed to characterize the optimized coatings. SEM images confirmed the deposition of chitosan/AgSr-HA on the SS substrate. The wettability studies indicated the hydrophilic nature of the chitosan/AgSr-HA composite coatings, which confirmed that the developed coatings are suitable for biomedical applications, e.g., orthopedics. The average surface roughness of the chitosan/AgSr-HA composite coatings was in a suitable range used to attach the bone marrow stromal cells. Chitosan/AgSr-HA composite coatings showed an effective antibacterial effect against Gram-positive and Gram-negative bacteria. Moreover, the coatings developed apatite crystals on their surface upon immersion in simulated body fluid.

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Section: Results and Discussionsupporting

confidence: 93%

Fabrication and Characterization of Ag–Sr-Substituted Hydroxyapatite/Chitosan Coatings Deposited via Electrophoretic Deposition: A Design of Experiment Study

et al. 2020

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“…The coated cpTi samples exhibited a higher hydrophilicity along with a significant enhancement in bioactivity. Moreover, they showed improved hemocompatibility as well as better osteoblast cell adhesion and proliferation [ 105 ].…”

Section: Active Layermentioning

confidence: 99%

Bioactive Coatings on Titanium: A Review on Hydroxylation, Self-Assembled Monolayers (SAMs) and Surface Modification Strategies

et al. 2021

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Titanium (Ti) and its alloys have been demonstrated over the last decades to play an important role as inert materials in the field of orthopedic and dental implants. Nevertheless, with the widespread use of Ti, implant-associated rejection issues have arisen. To overcome these problems, antibacterial properties, fast and adequate osseointegration and long-term stability are essential features. Indeed, surface modification is currently presented as a versatile strategy for developing Ti coatings with all these challenging requirements and achieve a successful performance of the implant. Numerous approaches have been investigated to obtain stable and well-organized Ti coatings that promote the tailoring of surface chemical functionalization regardless of the geometry and shape of the implant. However, among all the approaches available in the literature to functionalize the Ti surface, a promising strategy is the combination of surface pre-activation treatments typically followed by the development of intermediate anchoring layers (self-assembled monolayers, SAMs) that serve as the supporting linkage of a final active layer. Therefore, this paper aims to review the latest approaches in the biomedical area to obtain bioactive coatings onto Ti surfaces with a special focus on (i) the most employed methods for Ti surface hydroxylation, (ii) SAMs-mediated active coatings development, and (iii) the latest advances in active agent immobilization and polymeric coatings for controlled release on Ti surfaces.

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“…Vyas et al also developed biofunctionalization of titanium with chitosan/hydroxyapatite via silanization. 121 Hydroxyapatite is a bioactive ceramic largely used for biomaterial applications due to its similarity with natural bone. 122 These surfaces were able to significantly decrease in hemolysis percentage in comparison with cpTi.…”

Section: Strategies For Improving Hemocompatibility Of Titanium-based Implantsmentioning

confidence: 99%

“… 122 These surfaces were able to significantly decrease in hemolysis percentage in comparison with cpTi. 121 …”

Section: Strategies For Improving Hemocompatibility Of Titanium-based Implantsmentioning

confidence: 99%

“…122 These surfaces were able to significant decrease in hemolysis percentage in comparison with cpTi. 121 Zwitterionic polymers are known to be resistant to protein adsorption due to ionic interactions that rapidly creates a hydration layer on the surface. 69 Zwitterionic molecules have equal anion and cation groups on its chains, which make them highly hydrophilic and with natural antifouling properties.…”

Section: Materials Advances Accepted Manuscriptmentioning

confidence: 99%

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Surface modification strategies to improve titanium hemocompatibility: a comprehensive review

et al. 2021

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Biofunctionalization of commercially pure titanium with chitosan/hydroxyapatite biocomposite via silanization: evaluation of biological performances

Cited by 14 publications

References 32 publications

Fabrication and Characterization of Ag–Sr-Substituted Hydroxyapatite/Chitosan Coatings Deposited via Electrophoretic Deposition: A Design of Experiment Study

Fabrication and Characterization of Ag–Sr-Substituted Hydroxyapatite/Chitosan Coatings Deposited via Electrophoretic Deposition: A Design of Experiment Study

Bioactive Coatings on Titanium: A Review on Hydroxylation, Self-Assembled Monolayers (SAMs) and Surface Modification Strategies

Surface modification strategies to improve titanium hemocompatibility: a comprehensive review

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