Biofortification of Tomato (<i>Solanum lycopersicum</i>) Fruit with the Anticancer Compound Methylselenocysteine Using a Selenocysteine Methyltransferase from a Selenium Hyperaccumulator

Brummell, David A.; Watson, Lyn M.; Pathirana, Ranjith; Joyce, Nigel I.; West, Phillip; Hunter, Donald A.; McKenzie, Marian J.

doi:10.1021/jf202583f

Cited by 33 publications

(22 citation statements)

References 36 publications

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“…Agronomic Se-biofortiﬁcation strategies to increase crop Se contents by using inorganic Se fertilizers have been successfully implemented in Finland and New Zealand ( Lyons et al, 2003 ; Hartikainen, 2005 ; Premarathna et al, 2012 ; Schiavon et al, 2013 ; Wang et al, 2013b ). Different forms of Se supplied for biofortiﬁcation may result in different amounts and chemical forms of Se accumulated in plants ( Brummell et al, 2011 ; Schiavon et al, 2013 ; Pezzarossa et al, 2014 ). Due to chemical similarity to sulfate, selenate can be readily absorbed by plants, and plant leaves can accumulate substantial amounts of selenate, but much less selenite or SeMet ( De Souza et al, 1998 ; Zayed et al, 1999 ; Kikkert and Berkelaar, 2013 ).…”

Section: Developing Se-biofortified Agricultural Products For Human Hmentioning

confidence: 99%

Biofortification and phytoremediation of selenium in China

et al. 2015

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Selenium (Se) is an essential trace element for humans and animals but at high concentrations, Se becomes toxic to organisms due to Se replacing sulfur in proteins. Selenium biofortification is an agricultural process that increases the accumulation of Se in crops, through plant breeding, genetic engineering, or use of Se fertilizers. Selenium phytoremediation is a green biotechnology to clean up Se-contaminated environments, primarily through phytoextraction and phytovolatilization. By integrating Se phytoremediation and biofortification technologies, Se-enriched plant materials harvested from Se phytoremediation can be used as Se-enriched green manures or other supplementary sources of Se for producing Se-biofortified agricultural products. Earlier studies primarily aimed at enhancing efficacy of phytoremediation and biofortification of Se based on natural variation in progenitor or identification of unique plant species. In this review, we discuss promising approaches to improve biofortification and phytoremediation of Se using knowledge acquired from model crops. We also explored the feasibility of applying biotechnologies such as inoculation of microbial strains for improving the efficiency of biofortification and phytoremediation of Se. The key research and practical challenges that remain in improving biofortification and phytoremediation of Se have been highlighted, and the future development and uses of Se-biofortified agricultural products in China has also been discussed.

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Section: Developing Se-biofortified Agricultural Products For Human Hmentioning

confidence: 99%

Biofortification and phytoremediation of selenium in China

et al. 2015

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“…Yet, the range between beneficial and harmful concentration of Se is relatively narrow. In fact the World Health Organization (WHO) and the United States Department of Agriculture (USDA) recommend a daily intake of 55–200 μg Se in regular adults ( USDA, 2012 ) to reduce, for instance, the incidence of prostatic and lung cancer ( Brummell et al, 2011 ; Dennert et al, 2011 ). Doses greater than 400 μg Se per day on the other hand, might produce toxic effects, resulting in pathological conditions ( Rayman, 2008 ; Rayman, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Selenium Biofortification in Fragaria × ananassa: Implications on Strawberry Fruits Quality, Content of Bioactive Health Beneficial Compounds and Metabolomic Profile

et al. 2017

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Selenium (Se) is an essential nutrient for humans, due to its antioxidant properties, whereas, to date, its essentiality to plants still remains to be demonstrated. Nevertheless, if added to the cultivation substrate, plants growth resulted enhanced. However, the concentration of Se in agricultural soils is very variable, ranging from 0.01 mg kg-1 up to 10 mg kg-1 in seleniferous areas. Therefore several studies have been performed aimed at bio-fortifying crops with Se and the approaches exploited were mainly based on the application of Se fertilizers. The aim of the present research was to assess the biofortification potential of Se in hydroponically grown strawberry fruits and its effects on qualitative parameters and nutraceutical compounds. The supplementation with Se did not negatively affect the growth and the yield of strawberries, and induced an accumulation of Se in fruits. Furthermore, the metabolomic analyses highlighted an increase in flavonoid and polyphenol compounds, which contributes to the organoleptic features and antioxidant capacity of fruits; in addition, an increase in the fruits sweetness also was detected in biofortified strawberries. In conclusion, based on our observations, strawberry plants seem a good target for Se biofortification, thus allowing the increase in the human intake of this essential micronutrient.

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“…The SMT gene is inducible by selenate in broccoli (Lyi et al, 2005 ) and has been confirmed as the key to Se-tolerance in Se-accumulating plants (Neuhierl and Bock, 1996 ; Neuhierl et al, 1999 ). Its over-expression in non-Se accumulator species, such as tobacco and tomato, has been shown to convert such plants into Se-accumulators with up to 25% of the Se in these plants found as MeSeCys (McKenzie et al, 2009 ; Brummell et al, 2011 ).…”

Section: Selenium In Brassicalesmentioning

confidence: 99%

Mechanisms of Selenium Enrichment and Measurement in Brassicaceous Vegetables, and Their Application to Human Health

Wiesner-Reinhold¹,

Schreiner²,

Baldermann³

et al. 2017

Front. Plant Sci.

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Selenium (Se) is an essential micronutrient for human health. Se deficiency affects hundreds of millions of people worldwide, particularly in developing countries, and there is increasing awareness that suboptimal supply of Se can also negatively affect human health. Selenium enters the diet primarily through the ingestion of plant and animal products. Although, plants are not dependent on Se they take it up from the soil through the sulphur (S) uptake and assimilation pathways. Therefore, geographic differences in the availability of soil Se and agricultural practices have a profound influence on the Se content of many foods, and there are increasing efforts to biofortify crop plants with Se. Plants from the Brassicales are of particular interest as they accumulate and synthesize Se into forms with additional health benefits, such as methylselenocysteine (MeSeCys). The Brassicaceae are also well-known to produce the glucosinolates; S-containing compounds with demonstrated human health value. Furthermore, the recent discovery of the selenoglucosinolates in the Brassicaceae raises questions regarding their potential bioefficacy. In this review we focus on Se uptake and metabolism in the Brassicaceae in the context of human health, particularly cancer prevention and immunity. We investigate the close relationship between Se and S metabolism in this plant family, with particular emphasis on the selenoglucosinolates, and consider the methodologies available for identifying and quantifying further novel Se-containing compounds in plants. Finally, we summarize the research of multiple groups investigating biofortification of the Brassicaceae and discuss which approaches might be most successful for supplying Se deficient populations in the future.

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Biofortification of Tomato (Solanum lycopersicum) Fruit with the Anticancer Compound Methylselenocysteine Using a Selenocysteine Methyltransferase from a Selenium Hyperaccumulator

Cited by 33 publications

References 36 publications

Biofortification and phytoremediation of selenium in China

Biofortification and phytoremediation of selenium in China

Selenium Biofortification in Fragaria × ananassa: Implications on Strawberry Fruits Quality, Content of Bioactive Health Beneficial Compounds and Metabolomic Profile

Mechanisms of Selenium Enrichment and Measurement in Brassicaceous Vegetables, and Their Application to Human Health

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