Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Hu, Yanling; Ruan, Xiaohong; Lv, Xinyi; Xu, Yan; Wang, Wenjun; Cai, Yu; Ding, Meng; Dong, Heng; Shao, Jinjun; Yang, Dongliang; Dong, Xiaochen

doi:10.1016/j.nantod.2022.101602

Cited by 101 publications

(71 citation statements)

References 113 publications

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“…Exploiting biofilm characteristics such as local pH, hypoxia, and biofilm composition including the presence of enzymes such as amidase has led to targeted drug delivery techniques to release compounds within biofilms [ 129 , 130 ]. Recently, vancomycin was delivered using DNA NPs modified with pH-responsive lipids [ 131 ].…”

Section: Antimicrobials and Anti-biofilm Strategiesmentioning

confidence: 99%

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

et al. 2022

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Orthopaedic device implants play a crucial role in restoring functionality to patients suffering from debilitating musculoskeletal diseases or to those who have experienced traumatic injury. However, the surgical implantation of these devices carries a risk of infection, which represents a significant burden for patients and healthcare providers. This review delineates the pathogenesis of orthopaedic implant infections and the challenges that arise due to biofilm formation and the implications for treatment. It focuses on research advancements in the development of next-generation orthopaedic medical devices to mitigate against implant-related infections. Key considerations impacting the development of devices, which must often perform multiple biological and mechanical roles, are delineated. We review technologies designed to exert spatial and temporal control over antimicrobial presentation and the use of antimicrobial surfaces with intrinsic antibacterial activity. A range of measures to control bio-interfacial interactions including approaches that modify implant surface chemistry or topography to reduce the capacity of bacteria to colonise the surface, form biofilms and cause infections at the device interface and surrounding tissues are also reviewed.

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Section: Antimicrobials and Anti-biofilm Strategiesmentioning

confidence: 99%

Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

et al. 2022

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“…Additionally, once biofilms maturate, they become progressively resistant to antimicrobial therapies [ 13 , 14 , 15 , 16 , 17 ]. It is important to note that debridement is essential to not only stimulate cellular communication but to also disrupt biofilm formation.…”

Section: Wound Wars: Return Of the Biofilm!mentioning

confidence: 99%

“…However, the physical elimination of biofilm, clinical and in vitro models have established that debridement opens a time-dependent window during which applied topical treatments can suppress biofilm reformation [ 13 ]. Many studies have also shown the efficacy of changing cellular microenvironments in the permeation of biofilms [ 14 , 15 , 16 , 17 ].…”

Section: Wound Wars: Return Of the Biofilm!mentioning

confidence: 99%

Potential Utility of Ultrasound-Enhanced Delivery of Antibiotics, Anti-Inflammatory Agents, and Nutraceuticals: A Mini Review

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Sharma²,

Goransson³

et al. 2022

Antibiotics

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Ultrasound technology has therapeutic properties that can be harnessed to enhance topical drug delivery in a process known as phonophoresis. The literature on this method of drug delivery is currently sparse and scattered. In this review, we explore in vivo and in vitro controlled trials as well as studies detailing the mechanism of action in phonophoresis to gain a clearer picture of the treatment modality and explore its utility in chronic wound management. Upon review, we believe that phonophoresis has the potential to aid in chronic wound management, particularly against complicated bacterial biofilms. This would offer a minimally invasive wound management option for patients in the community.

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“…[5][6][7][8] The bacterial biofilm is composed of various EPS, which can serve as a fortress to protect the bacteria by hindering antibiotic diffusion and preventing host immune clearance. [9][10][11][12] Previous reports have indicated that biofilm formation is an important cause of chronic infections. 13 In clinical practices, the choices for the treatment of bacterial biofilm infections are limited to high-dose antibiotic treatment and surgical debridement.…”

Section: Introductionmentioning

confidence: 99%